Palladium-Catalyzed Site-Selective Arylation of α,β-Unsaturated Carbonyl Compounds through a Ligand-Controlled Strategy

Abstract

Palladium-catalyzed direct arylation of α,β-unsaturated carbonyl compounds is an efficient and attractive strategy to access arylated α,β-unsaturated carbonyl compounds through the construction of carbon–carbon bonds. This reaction has several challenges, especially in terms of the control of regioselectivity between α- and γ-arylation and the selectivity for monoarylation and multiple arylation. Herein, we discuss the recent development of γ-arylation of α,β-unsaturated carbonyl compounds and present the ligand-controlled, site-selective α- and γ-arylation of α,β-unsaturated carbonyl ketones with (hetero)aryl halides. The site selectivity of the reaction is switchable by simply changing the phosphine ligand.

1 Introduction

2 Reaction Development and Mechanistic Investigation

3 Conclusion and Outlook

Key words

palladium catalysis - phosphine ligand - regioselectivity - arylation - α,β-unsaturated ketones

Publikationsverlauf

Eingereicht: 05. Dezember 2021

Angenommen nach Revision: 23. Dezember 2021

Artikel online veröffentlicht:
01. Februar 2022

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