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DOI: 10.1055/s-0040-1709656
High-Flow Nasal Cannula versus Continuous Positive Airway Pressure in Critical Bronchiolitis: A Randomized Controlled Pilot
Funding This study was supported by Hospital Infantil Sabará and Instituto PENSI. High-flow devices and circuits were provided by Vapotherm, Inc. at no cost to the investigators. Vapotherm was not involved in the planning, execution, data analysis, data interpretation, or writing of the manuscript, and was not privy to its results.![](https://www.thieme-connect.de/media/10.1055-s-00029029/202004/lookinside/thumbnails/10-1055-s-0040-1709656_2000018-1.jpg)
Abstract
We conducted a randomized controlled pilot study in infants with critical bronchiolitis (n = 63) comparing high-flow nasal cannula (HFNC, n = 35) to continuous positive airway pressure (CPAP, n = 28). The primary outcome was treatment failure, defined as the need for bilevel positive pressure ventilation or endotracheal intubation. Treatment failure occurred in 10 patients (35.7%) in the CPAP group and 13 patients (37.1%) in the HFNC group (p = 0.88). Pediatric intensive care unit length of stay was similar between the CPAP and HFNC groups (5 [4–7] days and 5 [4–8] days, p = 0.46, respectively). In this pilot study, treatment with HFNC resulted in a rate of treatment failure similar to CPAP.
Keywords
bronchiolitis - high-flow nasal cannula - continuous positive airway pressure - respiratory syncytial virus - acute respiratory failure - infantsPublication History
Received: 03 February 2020
Accepted: 10 March 2020
Article published online:
17 April 2020
© 2020. Thieme. All rights reserved.
Georg Thieme Verlag KG
Stuttgart · New York
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