Gold Catalysis and Furans: A Powerful Match for Synthetic Connections

Abstract

This review summarizes the advances made on the synthesis and functionalization of furans via gold catalysis during the period between 2016 and 2020. A separate section is dedicated to the tandem gold-catalyzed synthesis and functionalization of furans.

1 Introduction

2 Gold-Catalyzed Synthesis of Furans

2.1 Cycloisomerizations of Alkynyl and Cumulenyl Alcohols

2.2 Cycloisomerizations of Alkynyl and Allenyl Ketones

2.3 Reactions with External Oxidants

2.4 Miscellaneous

3 Gold-Catalyzed Functionalization of Furans

3.1 Cycloadditions

3.2 Furan Ring Decorations

3.3 Reactions Involving Furan Ring Opening

4 Gold-Catalyzed Tandem Synthesis and Functionalization of Furans­

4.1 Cycloisomerizations Followed by Gold-Catalyzed Cycloaddition

4.2 Cycloisomerizations to a Gold 1,3- or 1,4-Dipole and Intermolecular Annulation

4.3 Cycloisomerizations to a Gold Carbene and Intermolecular Trapping

5 Conclusion

Key words

gold - furans - tandem reactions - alkynes - cycloisomerization - ring opening - cycloaddition

Publication History

Received: 05 October 2020

Accepted after revision: 05 November 2020

Article published online:
21 December 2020

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