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Semin Liver Dis 2020; 40(03): 225-232
DOI: 10.1055/s-0039-3402033
Review Article

Aging and the Biological Response to Liver Injury

Claudio Pinto
1   Department of Gastroenterology and Hepatology, Università Politecnica delle Marche, Ancona, Italy
,
Elisabetta Ninfole
1   Department of Gastroenterology and Hepatology, Università Politecnica delle Marche, Ancona, Italy
,
Laura Gaggiano
1   Department of Gastroenterology and Hepatology, Università Politecnica delle Marche, Ancona, Italy
,
Antonio Benedetti
1   Department of Gastroenterology and Hepatology, Università Politecnica delle Marche, Ancona, Italy
,
Marco Marzioni‡   *
1   Department of Gastroenterology and Hepatology, Università Politecnica delle Marche, Ancona, Italy
,
Luca Maroni   *
1   Department of Gastroenterology and Hepatology, Università Politecnica delle Marche, Ancona, Italy
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Abstract

Interest in understanding the aging process has recently risen in the scientific community. Aging, commonly defined as the functional decline in the function of organs and tissues, is indeed the major risk factor for the development of many chronic diseases, such as cardiovascular diseases, pathologies of nervous system, or cancer. To date, the influence of aging in the pathophysiology of liver and biliary diseases is not fully understood. Although liver cells have a high regenerative capacity, hepatocytes and cholangiocytes undergo extensive molecular changes in response to aging. Following time-dependent damage induced by aging, liver cells initially activate compensatory mechanisms that, if hyperstimulated, may lead to the decline of regenerative capacity and the development of pathologies. A deeper understanding of molecular aging has undoubtedly the potential to improve the clinical management of patients, possibly unveiling new pathways for selective drug treatment.

Keywords

aging - liver disease - senescence - DNA damage - cholangiocytes

* Co-senior authors.




Publication History

Article published online:
30 December 2019

© 2020. Thieme. All rights reserved.

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