J Knee Surg 2021; 34(06): 648-658
DOI: 10.1055/s-0039-1700494
Original Article

Computer-Navigated versus Conventional Total Knee Arthroplasty: A Meta-Analysis of Functional Outcomes from Level I and II Randomized Controlled Trials

Brian Zhaojie Chin
1   University Orthopaedics, Hand and Reconstructive Microsurgical Cluster, National University Health System, Singapore
,
Victor Mun Hin Seck
1   University Orthopaedics, Hand and Reconstructive Microsurgical Cluster, National University Health System, Singapore
,
Nicholas Li-Xun Syn
1   University Orthopaedics, Hand and Reconstructive Microsurgical Cluster, National University Health System, Singapore
,
Ian Jun Yan Wee
1   University Orthopaedics, Hand and Reconstructive Microsurgical Cluster, National University Health System, Singapore
,
Sharon Si Heng Tan
1   University Orthopaedics, Hand and Reconstructive Microsurgical Cluster, National University Health System, Singapore
,
Gavin Kane O’Neill
1   University Orthopaedics, Hand and Reconstructive Microsurgical Cluster, National University Health System, Singapore
› Author Affiliations
Funding None.
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Abstract

The main purpose of this article is to provide an up-to-date systematic review and meta-analysis comparing functional outcomes of total knee arthroplasty using either computer navigation (NAV-TKA) or conventional methods (CON-TKA) from the latest assemblage of evidence. This study was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Meta-Analysis of Observational Studies in Epidemiology guidelines. All Level I and II randomized controlled trials (RCTs) in PubMed, EMBASE, and Cochrane that compared functional outcomes after NAV- and CON-TKA were included in the review. Selected end points for random effects, pairwise meta-analysis included Knee Society Knee Score (KSKS), KS Function Score (KSFS), KS Total Score (KSTS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and range of motion at three arbitrary follow-up times. A total of 24 prospective RCTs comprising 3,778 knees were included from the initial search. At long-term follow-up (>5 years), NAV-TKA exhibited significantly better raw KSKS (p = 0.001) (low-quality evidence), contrary to CON-TKA, which reflected significantly better raw KSTS (p = 0.004) (high-quality evidence). While change scores (KSKS, WOMAC) from preoperative values favor CON-TKA at short-term (<6 months) and medium-term follow-up (6–60 months), long-term follow-up change scores in KSKS suggest the superiority of NAV-TKA over CON-TKA (p = 0.02) (very low-quality evidence). Overall, sizeable dispersion of nonstatistically significant functional outcomes in the medium term was observed to eventually converge in the long term, with less differences in functional outcome scores between the two treatment methods in short- and long-term follow-up. While raw functional outcome scores reflect no differences between NAV and CON-TKA, long-term follow-up change scores in KSKS suggest superiority of NAV-TKA over its conventional counterpart. Prospective studies with larger power are required to support the pattern of diminishing differences in functional outcome scores from medium- to long-term follow-up between the two modalities.

Supplementary Material



Publication History

Received: 08 May 2019

Accepted: 01 September 2019

Article published online:
04 November 2019

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