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Neuropediatrics 2019; 50(03): 160-163
DOI: 10.1055/s-0038-1676287
Original Article
Georg Thieme Verlag KG Stuttgart · New York

High Incidence of Renal Stones in Severely Disabled Children with Epilepsy Treated with Topiramate

Nobutsune Ishikawa
1   Department of Pediatrics, Hiroshima University Hospital, Hiroshima, Japan
2   Epilepsy Center, Hiroshima University Hospital, Hiroshima, Japan
,
Hiroo Tani
1   Department of Pediatrics, Hiroshima University Hospital, Hiroshima, Japan
2   Epilepsy Center, Hiroshima University Hospital, Hiroshima, Japan
,
Yoshiyuki Kobayashi
1   Department of Pediatrics, Hiroshima University Hospital, Hiroshima, Japan
2   Epilepsy Center, Hiroshima University Hospital, Hiroshima, Japan
,
Akira Kato
3   Suzugamine Facility for Persons with Severe Motor and Intellectual Disabilities, Hiroshima, Japan
,
Masao Kobayashi
1   Department of Pediatrics, Hiroshima University Hospital, Hiroshima, Japan
› Author Affiliations Disclosure of Funding This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
Further Information

Publication History

04 April 2018

16 October 2018

Publication Date:
02 April 2019 (online)

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Abstract

Purpose This study was aimed to assess the accurate incidence of renal stones in severely disabled children treated with topiramate (TPM).

Method We reviewed the medical records of severely disabled children with epilepsy under 15 years old who underwent radiological examinations to investigate urinary stones. The study enrolled 26 patients who were divided into two groups. One group had been treated with TPM for at least 1 year and the other had not been treated with TPM, zonisamide, acetazolamide, or other diuretic drugs. We collected parameters from the medical records and compared the groups.

Results All participants were evaluated radiologically, with computed tomography (CT) in two patients, ultrasonography in 22 patients, and both in two. No patient had any morphological abnormality of the kidneys and history of urinary tract infection. There were no significant differences in sex, age, body weight, or feeding manner between the groups, while the incidence of renal stones or calcifications was significantly higher in the TPM-treated group (60 vs. 0%; p = 0.00241).

Conclusion There is a high incidence of renal stone formation in severely disabled children treated with TPM.

Keywords

severely disabled children with epilepsy - antiepileptic drug - topiramate - renal stone - nonambulatory children
 

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