Download PDF
Thromb Haemost 1965; 13(01): 136-139
DOI: 10.1055/s-0038-1656292
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

Platelet Changes after Adrenaline Infusions with and without Adrenaline Blockers

P. D McClure   *
1   Department of Haematology, Louis Jenner Laboratories, St. Thomas’s Hospital and Medical School, London, S.E. I.
,
G. I. C Ingram
1   Department of Haematology, Louis Jenner Laboratories, St. Thomas’s Hospital and Medical School, London, S.E. I.
,
R Vaughan Jones
1   Department of Haematology, Louis Jenner Laboratories, St. Thomas’s Hospital and Medical School, London, S.E. I.
› Author Affiliations
Further Information

Publication History

Publication Date:
27 June 2018 (online)

    Permissions and Reprints

Summary

Adrenaline infusions into young, healthy, male subjects produced a rise in both platelet counts and platelet adhesiveness. Pronethalol, a ß-blocker of adrenaline, blocked these changes. Phentolamine, an α-blocker, produced a fall in platelet count which interfered with the interpretation of its blocking effect. The results suggested however, that Phentolamine did not prevent the increase in platelet adhesiveness produced by adrenaline.

* R. Samuel McLaughlin Travelling Fellow. Present address: Hospital for Sick Children, Toronto 2, Ontario, Canada.


 

  • References

  • 1 Shimamoto T. The Relationship of Edematous Reaction in Arteries to Arteriosclerosis and Thrombosis. J. Atheroscler. Res. 3: 87 1963;
    CrossrefPubMedGoogle Scholar
  • 2 Wright Helen P. The Sources of Blood Platelets and Their Adhesiveness in Experimental Thrombocytosis. J. Path. Bact. 56: 151 1944;
    CrossrefPubMedGoogle Scholar
  • 3 Vaughan Jones R, Ingram G. I. C, McGlure P. D. The Effect of Adrenaline on Factor VIII Levels and also on Platelet Count and Adhesiveness In Man. Abstracts, IX Congresso Da Sociedade Europeia De Hematologia. Lisboa, 1963
    PubMed
  • 4 Brecher G, Gronkite E. P. Morphology and Enumeration of Human Blood Platelets. J. appi. Physiol. 3: 365 1950;
    PubMedGoogle Scholar
  • 5 Hellem A. J. The Adhesiveness of Human Platelets in Vitro. Scand. J. clin. Lab. Invest.. 12: Suppl. 51 1960
    PubMedGoogle Scholar
  • 6 Wright Helen P. Changes in Adhesiveness of Blood Platelets Following Parturition and Surgical Operation. J. Path. Bact 54: 461 1942;
    CrossrefPubMedGoogle Scholar
  • 7 O’Brien J. R. Personal Communication
    PubMed
  • 8 O’Brien J. R. Some Effects of Adrenaline and Anti - Adrenaline Compounds on Platelets in Vitro and In Vivo. Nature 200: 763 1963;
    CrossrefPubMedGoogle Scholar
  • 9 Formell G. D, Ingram G. I. C. The Effect of Adrenaline Infusion on Human Blood Coagulation. J. Physiol. 135: 371 1957;
    CrossrefPubMedGoogle Scholar
  • 10 Ingram G. I. G. Increase in Antihaemophilic Globulin Activity Following Infusion of Adrenalin. J. Physiol. 156:27.1 1961
    PubMed
  • 11 Ozge A. H, Mustard J. F, Hegardt B, Rowsell H. C, Downie H. G. The Effect of Adrenaline on Blood Coagulation, Platelet Economy and Thrombus Formation. Canad. med. Ass. J. 88: 265 1963;
    PubMedGoogle Scholar
  • 12 Subairov D. M, Deryanina G. I. Effects of Changes in Blood Coagulability on the Adhesive Power of Platelets. Tsitologiya 4: 465 1962;
    PubMedGoogle Scholar