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Thromb Haemost 1966; 16(01/02): 185-197
DOI: 10.1055/s-0038-1655636
Originalarbeiten — Original Articles — Travaux Originaux
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A Study of Coagulation Factor Levels in Women during Labour and in Their Newborn Infants

H. L Nossel   *
1   Departments of Medicine and Child Health, University of Cape Town and Groote Schuur Hospital, Observatory, Cape, South Africa
,
P Lanzkowsky   **
1   Departments of Medicine and Child Health, University of Cape Town and Groote Schuur Hospital, Observatory, Cape, South Africa
,
S Levy
1   Departments of Medicine and Child Health, University of Cape Town and Groote Schuur Hospital, Observatory, Cape, South Africa
,
R. S Mibashan
1   Departments of Medicine and Child Health, University of Cape Town and Groote Schuur Hospital, Observatory, Cape, South Africa
,
J. D. L Hansen
1   Departments of Medicine and Child Health, University of Cape Town and Groote Schuur Hospital, Observatory, Cape, South Africa
› Author Affiliations
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Publication History

Publication Date:
26 June 2018 (online)

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Summary

1. Coagulation factors levels were measured in 10 normal mothers and in their infants within 15 min of birth and at 48-96 hrs of age.

2. In the mothers the levels of fibrinogen (532 mg/%), factors VIII (196%), IX (130%) and X (122%) were elevated; the levels of prothrombin (107%) and factor V (108%) were normal ; and the level of factor XI (69%) was reduced.

3. The infants blood examined within 15 min of birth had a slightly elevated factor VIII level (138%), slightly reduced fibrinogen (195 mg/%) and factor V levels (79%), low levels of prothrombin (55%) and factors IX (27%), X (35%) and XI (32%).

4. Blood from the infants at 48-96 hrs of age showed little change from the birth levels of factors V (89%), and VIII (116%) and a slight increase in factor XI level (39%). Four of the infants had received vitamin K1 and had higher levels of prothrombin and factors IX and X than the 7 who had not received vitamin K1.

5. These results are compared with those of previous studies and the possible mechanisms underlying the changes is discussed.

* Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, N. Y.


** Pediatric Hematology Division, Cornell University Medical Center, New York, N. Y. 1) Konakion (Roche).


 

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