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Thromb Haemost 1966; 16(01/02): 061-068
DOI: 10.1055/s-0038-1655627
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

A Comparative Study of the Solvents Commonly Used to Detect Fibrin Stabilisation

H. M Tyler
1   Department of Pathology, Institute of Orthopaedics, (University of London), Brockley Hill, Stanmore, Middlesex
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Publication Date:
26 June 2018 (online)

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Summary

The actions of 2% acetic acid, 1% monochloracetic acid and 8 M urea have been studied on fibrin of the “soluble” and “insoluble” types. The two acidic reagents have a much more rapid solubilising action than does 8 M urea, and are also more efficient in solubilising “partially stabilised” fibrin.

Provided sufficient time is allowed for a fibrin or whole-blood clot to form, it seems unlikely that qualitative differences in the solubilising action of the three solvents will be found.

For a clinical assessment of the stabilisation of blood-clot, examination can be made after 1 hr incubation of the clot in either of the acidic solvents. There is no apparent advantage in the commonly used prolonged incubations in 5 or 8 M urea.

 

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