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Thromb Haemost 1977; 38(02): 0438-0446
DOI: 10.1055/s-0038-1651479
Original Article
Schattauer GmbH

The Activation of Plasma Factor XIII with the Snake Venom Enzymes Ancrod and Batroxobin Marajoensis

M Walter
1   Coagulation and Fibrinolysis Laboratories, Kantonsspital, Basle, Switzerland
,
D Nyman
1   Coagulation and Fibrinolysis Laboratories, Kantonsspital, Basle, Switzerland
,
V Krajnc
1   Coagulation and Fibrinolysis Laboratories, Kantonsspital, Basle, Switzerland
,
F Duckert
1   Coagulation and Fibrinolysis Laboratories, Kantonsspital, Basle, Switzerland
› Author Affiliations
Further Information

Publication History

Received 06 December 1976

Accepted 30 March 1977

Publication Date:
04 July 2018 (online)

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Summary

The snake venom enzymes Ancrod and Batroxobin marajoensis are able to activate human plasma factor XIII as shown by the formation of the γ-dimers. The concentration of γ-dimers increases with the concentration of the activating enzymes. Factor XIII activated by Ancrod or Batroxobin marajoensis is, however, unable to catalyse the incorporation of the amine dansylcadaverine into casein. The partially activated factor XIII is therefore not demonstrable by means of the artificial test system. This factor XIII loses little activity and remains activable by thrombin.

 

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