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Thromb Haemost 1975; 34(01): 236-245
DOI: 10.1055/s-0038-1651371
Original Article
Schattauer GmbH

Plasma Fibrinolytic Activity Following Oral Anabolic Steroid Therapy

I. D Walker
1   Department of Haematology, Royal Infirmary, Glasgow
,
J. F Davidson
1   Department of Haematology, Royal Infirmary, Glasgow
,
P Young
1   Department of Haematology, Royal Infirmary, Glasgow
,
J. A Conkie
1   Department of Haematology, Royal Infirmary, Glasgow
› Author Affiliations
Further Information

Publication History

Received 17 February 1975

Accepted 01 March 1975

Publication Date:
02 July 2018 (online)

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Summary

Six anabolic steroids were assessed for their ability to enhance plasma fibrinolytic activity in males with ischaemic heart disease. Five 17α-alkylated steroids (Ethyloestrenol, Norethandrolone, Methandienone, Methylandrostenediol and Oxymetholone) were examined and all produced a significant increase in plasma plasminogen activator as measured by the euglobulin lysis time. The only non-17α-alkylated steroid studied (Methenolone acetate) failed to enhance fibrinolysis. The 17α-alkylated steroids studied all deserve more detailed evaluation of their long term effects on plasma fibrinolytic activity.

 

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