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Thromb Haemost 1968; 19(01/02): 242-247
DOI: 10.1055/s-0038-1651202
Originalarbeiten – Original Articles – Travaux Originaux
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The Modification of Experimental Occlusive Arterial Thrombosis in the Rat by Malayan Pit Viper Venom

K. E Chan M. B., B. S., Ph. D
1   Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
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Publication History

Publication Date:
27 June 2018 (online)

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Summary

The effect of Malayan pit viper (Ancistrodon rhodostoma) venom on the fate of experimental arterial thrombosis was studied in rats. A suitable daily dose of venom (500 μg) was used to induce hypofibrinogenaemia in the treated rats for the greater part of each of three consecutive post-operative days.

The treated animals showed a statistically significant overall reduction in the incidence of both red thrombus formation and thrombotic arterial occlusion when compared to a control group. This antithrombotic effect of the venom could be observed in the 7-day period following the cessation of the treatment.

 

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