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Thromb Haemost 1966; 15(03/04): 554-560
DOI: 10.1055/s-0038-1649458
Originalarbeiten — Original Articles — Travaux Originaux
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The Kidneys and the Liver as the Organs Regulating the Fibrinolytic System of the Circulating Blood[*]

T Januszko
1   Department of General and Experimental Pathology School of Medicine, Bialystole – Poland (Head: Prof. Karol Buluk)
,
M Furman
1   Department of General and Experimental Pathology School of Medicine, Bialystole – Poland (Head: Prof. Karol Buluk)
,
K Buluk
1   Department of General and Experimental Pathology School of Medicine, Bialystole – Poland (Head: Prof. Karol Buluk)
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Publication Date:
24 July 2018 (online)

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Summary

In experiments on rabbits it was shown by means of interruption and reestablishment of hepatic and renal circulation that these organs play an essential role in the regulation of the fibrinolytic system of the circulating blood. The kidneys are the source of the plasminogen activator secreted in the blood whereas the liver is responsible for the inactivation of the fibrinolytic system.

* This investigation was supported by a grant from the Thema Panel “Pathogenesis of Shock” Section of Medical Sciences, Polish Academy of Sciences.


 

  • References

  • 1 Buluk K, Furman M. On the controlling function of the kidneys in fibrinolysis. Experientia (Basel) 18: 146 1962;
    CrossrefPubMedGoogle Scholar
  • 2 Buluk K, Malofiejew M. Preparation of fibrinolysis activator in the extracorporal kidney. Acta physiol, pol 14: 351 1963;
    PubMedGoogle Scholar
  • 3 Dorobisz T, Janiakowa A. Ostry zespôl fibrynolityczny w przebiegu operacji w zwi¹zku z marskoœci¹ w¹troby. Pol. Tyg. lek 17: 639 1962;
    PubMedGoogle Scholar
  • 4 Fearnley G. R. Plasma fibrinolytic activity in cirrhosis of the liver. Lancet 270: 450 1956;
    PubMedGoogle Scholar
  • 5 Fletcher A. P, Biederman O, Moore D, Alkjaersig N, Sherry S. Abnormal plasminogenplasmin system activity (fibrinolysis) in patients with hepatic cirrhosis: its cause and consequences. J. clin. Invest 43: 681 1964;
    CrossrefPubMedGoogle Scholar
  • 6 Furman M. Aktywacja fibrynolizy krwi kr¹z¹cej królika. Roczn. Akad. Med. Marchlewskiego 09: 373 1963;
    PubMedGoogle Scholar
  • 7 Grossi C. E, Rousselot L. M, Panke W. F. Control of fibrinolysis during portacaval shunts. JAMA 187: 1005 1964;
    PubMedGoogle Scholar
  • 8 Jürgens J, Beller F. K. Klinische Methoden der Blutgerinnungsanalyse. Thieme, Stuttgart: 1959
    Google Scholar
  • 9 Kwaan H. G, McFadzean A. J. S, Gook J. Plasma fibrinolytic activity in cirrhosis of the liver. Lancet 270: 132 1956;
    PubMedGoogle Scholar
  • 10 Marchai G, Frileux C. L, Bilski-Pasquier G, Weiss M, Cornet P, Samama M, Larrieu M. Fibrinolyse mortelle au cours d’une anastomose porto-cave pour cirrhose compliquée d’hématémèses récidivantes. Presse méd 67: 1851 1959;
    PubMedGoogle Scholar
  • 11 de Nicola P, Soardi F. Fibrinolysis in liver diseases. Study of 109 cases by means of the fibrin plate method. Thrombos. Diathes. haemorrh. (Stuttg) 02: 290 1958;
    PubMedGoogle Scholar
  • 12 Niewiarowski S, Prokopowicz J, Poplawski A, Worowski K. Inhibition of dog fibrinolytic system in experimental tubular necrosis of kidney. Experientia (Basel) 20: 101 1964;
    CrossrefPubMedGoogle Scholar
  • 13 Nolf P, Adant M. De l’intervention du foie dans les phénomènes de la coagulation du sang. Sang 02: 257 1951;
    PubMedGoogle Scholar
  • 14 Perlick E. Hämorrhagische Diathesen. VEB Georg Thieme, Leipzig: 1962
    Google Scholar
  • 15 Phillips L. L, Skrodelis V. The fibrinolytic enzyme system in normal, hemorrhagic and disease states. J. clin. Invest 37: 965 1958;
    CrossrefPubMedGoogle Scholar
  • 16 Quick A. J. The physiology and pathology of hemostasis. Kimpton, London: 1951
    Google Scholar
  • 17 Rousselot L. M, Cazes B, Grossi C. E. L’inactivation par le foie des enzymesfibrinolytiques. Presse méd 71: 2677 1963;
    PubMedGoogle Scholar