Download PDF
Thromb Haemost 1966; 15(03/04): 390-402
DOI: 10.1055/s-0038-1649440
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

Blood Factor XI after Fat-Rich Meals

O Egeberg
1   The Institute for Thrombosis Research, Medical Department A, Rikshospitalet, Oslo, Norway
› Author Affiliations
Further Information

Publication History

Publication Date:
24 July 2018 (online)

Also available at
    Permissions and Reprints

Summary

Controlled meals were given to normal persons and to certain patients, and blood coagulation was investigated before and after the meal, especially with an assay sensitive for activated antihemophilic C factor (AHC5 = activated f. XI).

After bread and rich amounts of margarine (produced mainly from hydrogenated marine oils), the AHC’ assay in fresh plasma registered a significant acceleration about 5 hours after the meal. No significant changes were measured in the levels of AHA (f. VIII), AHB (f. IX) and proconvertin (f. VII). A weaker tendency to acceleration in AHC5 assay seemed also to occur after intake of vegetable margarine (produced from hydrogenated vegetable oils). Bread with low or high amounts of cow butter gave no acceleration.

The active principle in the postprandial plasmas could not be demonstrated after a few days of storage at — 20° C.

The hypothesis that the acceleration effect is due to an activation of blood AHC was supported by the observation that no corresponding effect was measured after margarine meals to patients with AHC deficiency.

Patients with von Willebrand’s disease showed the same activation as normals.

The activation seemed to be prevented by intake of linseed oil prior to the margarine meal.

The results are discussed.

 

  • References

  • 1 Aas K. Prokonvertin og konvertin. 21 Akad. Trykningssentral; Oslo: 1952
    Google Scholar
  • 2 Botti R. E, Ratnoff O. D. The clot-promoting effect of soaps of long-chain saturated fatty acids. J. clin. Invest 42: 1569 1963;
    CrossrefPubMedGoogle Scholar
  • 3 Brenner R. R, José P. Action of linolenic and docosahexaenoic acids upon the eicosatrienoic acid level in rat lipids. J. Nutr 85: 196 1965;
    CrossrefPubMedGoogle Scholar
  • 4 Connor W. E. The acceleration of thrombus formation by certain fatty acids. J. clin. Invest 41: 1199 1962;
    CrossrefPubMedGoogle Scholar
  • 5 Connor W. E, Hoak J. C, Warner E. D. Massive thrombosis produced by fatty acid infusions. J. clin. Invest 42: 860 1963;
    CrossrefPubMedGoogle Scholar
  • 6 Connor W. E, Poole J. C. F. The effect of fatty acid on the formation of thrombi. Quart. J. exp. Physiol 46: 1 1961;
    PubMedGoogle Scholar
  • 7 Didisheim P, Mibashan R. S. Activation of Hageman factor (factor XII) by long-chain saturated fatty acids. Thrombos. Diathes. haemorrh. (Stuttg) 09: 346 1963;
    PubMedGoogle Scholar
  • 8 Egeberg O. Assay of antihemophilic A, B and C factors by one-stage cephalin systems. Scand. J. clin. Lab. Invest 13: 140 1961;
    CrossrefPubMedGoogle Scholar
  • 9 Egeberg O. On the natural blood coagulation inhibitor system. Investigations of inhibitor factors based on antithrombin deficient blood. Thrombos. Diathes. haemorrh. (Stuttg) 14: 473 1965;
    PubMedGoogle Scholar
  • 10 Hellem A. J. The adhesiveness of human blood platelets in vitro. Oslo University Press; Oslo: 1960
    Google Scholar
  • 11 Henderson E. S, Rapaport S. I. The thrombotic activity of activation product. J. clin. Invest 41: 295 1962;
    PubMedGoogle Scholar
  • 12 Hjort P. F. Intermediate reactions in the coagulation of blood with tissue thromboplastin. Convertin, accelerin, prothrombinase. Scand. J. clin. Lab. Invest 09 Suppl. 27 1957;
    PubMedGoogle Scholar
  • 13 Hjort P. F, Rapa S. I, Owrenport P. A. A simple one-stage prothrombin assay using Russell’s viper venom in cephalin suspension. J. Lab. clin. Med 46: 89 1955;
    PubMedGoogle Scholar
  • 14 Hoak J. C, Connor W. E, Eckstein J. W, Warner E. D. Fatty acid-induced thrombosis and death: Mechanism and prevention. J. Lab. clin. Med 63: 791 1964;
    PubMedGoogle Scholar
  • 15 Holman R. T. Nutrional and metabolic interrelationships between fatty acids. Fed. Proc 23: 1062 1964;
    PubMedGoogle Scholar
  • 16 latridis S. G, Ferguson J. H, latridis P. G, Mauldin R. Thrombogenic properties of surface factor; evidence for an anti-surface factor activity in canine plasma. Thrombos. Diathes. haemorrh. (Stuttg) 12: 35 1964;
    PubMedGoogle Scholar
  • 17 latridis S. G, latridis P. G, Ferguson J. H. Rôles of surface factor and a plasma inhibitory activity (Anti-SF) during experimental thrombosis in rabbits. Thrombos. Diathes. haemorrh. (Stuttg) 12: 489 1964;
    PubMedGoogle Scholar
  • 18 Johnston Jr. G. L, Ferguson J. H, O’Hanlon F. A. Surface activation of plasma clotting : A function of Hageman factor. Proc. Soc. exp. Biol. (N.Y) 99: 197 1958;
    CrossrefPubMedGoogle Scholar
  • 19 Lewis J. H, Merchant W. R. The probable identity of glass factor with Hageman factor. J, clin. Invest 37: 911 1958;
    PubMedGoogle Scholar
  • 20 Margolis J. Glass surface and blood coagulation. Nature (Lond.) No 4537: 10 1956;
    PubMedGoogle Scholar
  • 21 Margolis J. Plasma pain-producing substance and blood clotting. Nature (Lond) 180: 1464 1957;
    CrossrefPubMedGoogle Scholar
  • 22 Margolis J. Activation of plasma by contact with glass : Evidence for a common reaction which releases plasma kinin and initiates coagulation. J. Physiol. (Lond) 144: 1 1958;
    PubMedGoogle Scholar
  • 23 Margolis J. Activation of a permeability factor in plasma by contact with glass. Nature (Lond) 181: 635 1958;
    CrossrefPubMedGoogle Scholar
  • 24 Margolis J. Hageman factor and capillary permeability. Aust. J. exp. Biol. med. Sei 37: 239 1959;
    PubMedGoogle Scholar
  • 25 Margolis J. Activation of Hageman factor by saturated fatty acids. Aust. J. exp. Biol. med. Sei 40: 505 1962;
    PubMedGoogle Scholar
  • 26 Nossel H. L. The contact phase of blood coagulation. Blackwell; Oxford 1964.:
    Google Scholar
  • 27 Owren P. A. The coagulation of blood. Investigations on a new clotting factor. Acta med. scand 128 Suppl. 194 1947;
    PubMedGoogle Scholar
  • 28 Owren P. A, Hellem A. J, Ödegaard A. Linolenic acid for the prevention of thrombosis and myocardial infarction. Lancet II: 975 1964;
    PubMedGoogle Scholar
  • 29 Ratnoff O. D, Colopy J. E. A familial hemorrhagic trait associated with a deficiency of clotpromoting fraction of plasma. J. clin. Invest 34: 602 1955;
    CrossrefPubMedGoogle Scholar
  • 30 Ratnoff O. D, Crum J. D. Activation of Hageman factor by solutions of ellagic acid. J. Lab. clin. Med 63: 359 1964;
    PubMedGoogle Scholar
  • 31 Ratnoff O. D, Davie W. The activation of Christmas factor (factor IX) by activated plasma thromboplastin antecedent (activated factor XI). Biochemistry 01: 677 1962;
    CrossrefPubMedGoogle Scholar
  • 32 Ratnoff O. D, Davie W, Mallett D. L. Studies on the action of Hageman factor : Evidence that activated Hageman factor in turn activates plasma thromboplastin antecedent. J. clin. Invest 40: 803 1961;
    CrossrefPubMedGoogle Scholar
  • 33 Ratnoff O. D, Rosenblum J. M. Rôle of Hageman factor in the initiation of clotting by glass. Amer. J. Med 25: 160 1958;
    CrossrefPubMedGoogle Scholar
  • 34 Rosenthal R. L, Dreskin O. H, Rosenthal N. New hemophilia-like disease caused by deficiency of a third plasma thromboplastin factor. Proc. exp. Soc. Biol. (N. Y) 82: 171 1953;
    PubMedGoogle Scholar
  • 35 Sinclair H. M. Deficiency of essential fatty acids and atherosclerosis, etcetera. Lancet I: 381 1956;
    PubMedGoogle Scholar
  • 36 Soulier J. P, Wartelle O, Ménaché D. Hageman trait and PTA deficiency ; the role of contact of blood with glass. Brit. J. Haemat 05: 121 1959;
    CrossrefPubMedGoogle Scholar
  • 37 Studnitz von W. Studies on serum lipids and lipoproteins in pregnancy. Scand. J. clin. Lab. Invest 07: 329 1955;
    CrossrefPubMedGoogle Scholar
  • 38 Swahn B. Studies in blood lipids. Scand. J. clin Lab. Invest. 5 Suppl. 09 1953
    Google Scholar
  • 39 Waaler B. A. Contact activation in the intrinsic blood clotting system. Scand. J. clin. Lab. Invest. 11 Suppl. 37 1959
    Google Scholar
  • 40 Webster M. E, Ratnojf O. D. Rôle of Hageman factor in the activation of vasodilator activity in human plasma. Nature (Lond.) No 4798 180 1961;
    PubMedGoogle Scholar
  • 41 Wessler S. S. Thrombosis in the presence of vascular stasis. Amer. J. Med 33: 648 1962;
    CrossrefPubMedGoogle Scholar
  • 42 Wessler S. S, Reimer S. M. The rôle of human coagulation factors in serum-induced thrombosis. J. clin. Invest 39: 262 1960;
    CrossrefPubMedGoogle Scholar