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Thromb Haemost 1976; 35(03): 643-650
DOI: 10.1055/s-0038-1647963
Original Article
Schattauer GmbH

Plasmin inactivation in Plasma

E. M Haselager
1   Department of Internal Medicine, University Hospital Wilhelmina Gasthuis, Amsterdam, The Netherlands
,
Th. M Goote
1   Department of Internal Medicine, University Hospital Wilhelmina Gasthuis, Amsterdam, The Netherlands
,
J Vreeken
1   Department of Internal Medicine, University Hospital Wilhelmina Gasthuis, Amsterdam, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 06 October 1975

Accepted 12 December 1975

Publication Date:
24 July 2018 (online)

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Summary

Inhibition and inactivation of plasmin is ascribed to α2-macroglobulin, α1-antitrypsin and c1-esterase inhibitor. In an “overall” inactivation test of plasmin in plasma, which comes perhaps closest to rapid inactivation of plasmin in the circulating blood, we only found a correlation between the immunological concentration of α2-macroglobulin and the plasmin-inac-tivating capacity of the plasma, but no correlation with the immunological concentration of the other inhibitors mentioned. Therefore, α2-macroglobulin seems to be the most important plasmin inhibitor in relation to thrombosis.

 

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