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Thromb Haemost 1974; 32(02/03): 266-276
DOI: 10.1055/s-0038-1647697
Original Article
Schattauer GmbH

Fibrinogen-Fibrin-Related Antigen Pattern in Human Blood

Differences between Plasma and Serum from Patients with Disseminated Intravascular Coagulation
Carl D. Jacobsen
1   Department of Pathology and The Blood Coagulation Research Laboratory, Department of Medicine, University of Iowa, Iowa City, Iowa 52242, U.S.A
,
John C. Hoak
1   Department of Pathology and The Blood Coagulation Research Laboratory, Department of Medicine, University of Iowa, Iowa City, Iowa 52242, U.S.A
,
Kenneth K. WU
1   Department of Pathology and The Blood Coagulation Research Laboratory, Department of Medicine, University of Iowa, Iowa City, Iowa 52242, U.S.A
,
Glenna L. Fry
1   Department of Pathology and The Blood Coagulation Research Laboratory, Department of Medicine, University of Iowa, Iowa City, Iowa 52242, U.S.A
› Author Affiliations
Further Information

Publication History

Received 08 October 1973

Accepted 10 June 1974

Publication Date:
30 June 2018 (online)

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Summary

In serum from patients with DIC at least 3 different FR-antigenic components could be found. It was difficult to demonstrate these components in the corresponding plasma samples. It is possible that a portion of these antigens formed as a result of in vitro clotting despite the presence of proteolytic inhibitors. These results suggest that the interpretation of “increased split products in serum” may be more complex than current concepts indicate.

 

  • References

  • 1 Arnesen H, Godal H. C. 1973; Studies on the thrombin clotting time. I. The influence of fibrinogen degradation products. Scandinavian Journal of Haematology 10: 232.
    PubMedGoogle Scholar
  • 2 Arnesen H. 1973; Studies on thrombin clotting time. II. The influence of fibrin degradation products. Scandinavian Journal of Haematology 10: 291.
    PubMedGoogle Scholar
  • 3 Blombäck B, Blombäck M. 1956; Purification of human and bovine fibrinogen. Arkiv Kemi 10: 415.
    PubMedGoogle Scholar
  • 4 Bouma B. N, Hednee I. T, Niesson I. M. 1971; Typing of fibrinogen degradation products in urine in various clinical disorders. Scandinavian Journal of Clinical and Laboratory Investigation 27: 331.
    CrossrefPubMedGoogle Scholar
  • 5 Clarke H. G, Minchin Freeman T. 1968; Quantitative immunoelectrophoresis of human serum proteins. Clinical Science 35: 403.
    PubMedGoogle Scholar
  • 6 Editorial. 1972; F. D. P., The Lancet 02: 957.
    PubMedGoogle Scholar
  • 7 Godal H. C, Abildgaard U. 1966; Gelation of soluble fibrin in plasma by ethanol. Scandinavian Journal of Haematology 03: 342.
    PubMedGoogle Scholar
  • 8 Jacobsen C. D. 1968; The use of N-ethyl-urethan in plasma plasminogen assay. Scandinavian Journal of Clinical and Laboratory Investigation 21: 182.
    CrossrefPubMedGoogle Scholar
  • 9 Marder V. J. 1968. Immunologic structure of fibrinogen and its plasmin degradation products: Theoretical and clinical considerations. In: Laki K. (ed.), Fibrinogen. Marcel Dekker, Inc: New York; 339.
    Google Scholar
  • 10 Marder V. J. 1968. Immunologic structure of fibrinogen and its plasmin degradation products: Theoretical and clinical considerations. In: Laki K. (ed.), Fibrinogen. Marcel Dekker, Inc; New York: 339.
    Google Scholar
  • 11 Marder V. J, Shulman N. R, Carroll W. R. 1969; High molecular weight derivatives of human fibrinogen produced by plasmin. I. Physicochemical and immunological characterization. The Journal of Biological Chemistry 244: 2111.
    PubMedGoogle Scholar
  • 12 Marder V. J, Shulman N. R. 1969; High molecular weight derivatives of human fibrinogen produced by plasmin. II. Mechanism of their anticoagulant activity. The Journal of Biological Chemistry 244: 2120.
    PubMedGoogle Scholar
  • 13 Merskey C, Lalezari P, Johnson A. J. 1969; A rapid, simple, sensitive method for measuring fibrinolytic split products in human serum. Proceedings of the Society for Experimental Biology and Medicine 131: 871.
    PubMedGoogle Scholar
  • 14 Merskey C, Johnson A. J, Lalezari P. 1972; Increase in fibrinogen and fibrinrelated antigen in human serum due to in vitro lysis of fibrin by thrombin. The Journal of Clinical Investigation 51: 903.
    CrossrefPubMedGoogle Scholar
  • 15 Niewiarowski S, Kowalski E. 1958; Un nouvel anticoagulant dérivé du fibrinogène. Revue D’Hématologie 13: 320.
    PubMedGoogle Scholar
  • 16 Nussenzweig Y, Seligman M. 1960; Analyse, par des methodes immunochimiques, des la degradation par la plasmine du fibrinogène humain et de la fibrine, à différents stades. Revue D’Hematologie 15: 451.
    PubMedGoogle Scholar
  • 17 Nussenzweig Y, Seligman M, Pelmont J, Grabar P. 1961; a Les produits de dégradation du fibrinogène humain par la plasmine. I. Separation et propriétés physicochimiques. Annales de L’Institut Pasteur 100: 377.
    PubMedGoogle Scholar
  • 18 Nussenzweig y, Seligman M, Grabar P. 1961; b Les produits de degradation du fibrinogène humain par la plasmine. II. Étude immunologique : mise en évidence d’anticorps anti-fibrinogène natif possédant des spécificités différentes. Annales de L’Institut Pasteur 100: 490.
    PubMedGoogle Scholar
  • 19 Ottchterlony O. 1948; Antigen-antibody reactions in gel. Arkiv Kemi, Mineralogi och Geologi, 26 B: 1.
    PubMedGoogle Scholar
  • 20 Pizzo S. V, Schwartz M. L, Hill P. L, McKee P. A. 1972; The effect of plasmin on the subunit structure of human fibrinogen. The Journal of Biological Chemistry 247: 636.
    PubMedGoogle Scholar
  • 21 Plow E, Edgington T. S. 1973; Immunobiology of fibrinogen. Emergence of neoantigenic expressions during physiologic cleavage in vitro and in vivo. The Journal of Clinical Investigation 52: 273.
    CrossrefPubMedGoogle Scholar
  • 22 Salmon J. 1959; Étude immunochimique du fibrinogène et de ses dérivés. Clinica Chimica Acta 04: 767.
    CrossrefPubMedGoogle Scholar
  • 23 Scheidegger J. J. 1955; Une microméthode de l’immunoelectrophorese. International Archives in Allergy 07: 103.
    PubMedGoogle Scholar
  • 24 Stormorken H. 1957; Reactivity of stored plasma to thrombin, with reference to the fibrinogen conversion accelerator and heparinoid activity. British J ournal of Haematology 03: 299.
    PubMedGoogle Scholar
  • 25 Triantaphyllopoulos D. C, Quick A. J, Greenwalt T. J. 1955; Action of disodium ethylenediamine tetracetate on blood coagulation. Evidence of the development of heparinoid activity during incubation or aeration of plasma. Blood 10: 534.
    PubMedGoogle Scholar