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Methods Inf Med 1991; 30(02): 102-107
DOI: 10.1055/s-0038-1634829
Clinical Application
Schattauer GmbH

Robust Trend Analysis in Predicting Histamine Provocation Concentration

E. Krusińska
1   Institute of Computer Science, University of Wroclaw, Poland
,
J. Liebhart
2   Department of Internal Diseases and Allergology, Medical Academy of Wroclaw, Poland
,
M. Woźniak
1   Institute of Computer Science, University of Wroclaw, Poland
› Author AffiliationsThis study was partially sponsored by the Polish Government grant V.07 CPBP 02.20. A preliminary version of the paper was presented during the 10th International Meeting of the International Society for Clinical Bio-statistics, Maastricht (The Netherlands), September 1989. The authors are grateful to the Society and to the University of Limburg for financial support making the presentation possible. They would like to thank all those participating in the discussion for their valuable remarks, which have enabled to enrich the study.
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Publication History

Publication Date:
07 February 2018 (online)

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Abstract

Trend analysis is used to predict the histamine provocation concentration PC20 during the so-called challenge test, where increasing doses of the bronchoconstricting agent are given to a patient and the spirometric examination is subsequently performed. Classical least-squares analysis of trends as well as least absolute deviations analysis are compared. The results are interesting and promising from a statistical as well as medical point of view. The methods presented can be applied to many practical problems in medicine.

Key-Words

Histamine Test - L1-estimation - Prediction - Provocation Concentration PC20 - Trend Analysis
 

  • REFERENCES

  • 1 Pepys J, Hutchcroft BJ. Bronchial provocation tests in etiologic diagnosis and analysis of asthma. Amer Rev Resp Dis 1975; 112: 829-59.
    PubMedGoogle Scholar
  • 2 Chai H, Farr RS, Froehlich LA. et al. Standardization of bronchial inhalation procedures. J Allergy Clin Immunol 1975; 56: 323-7.
    CrossrefPubMedGoogle Scholar
  • 3 SEPCR Working Group on Bronchial Hyperreactivity. In: Elser NM, Korrabiju KF, Quanjer PH. eds Guidelines for standardization of bronchial challenges with nonspecific bronchoconstricting agents. Bull Europ Physiopath Resp 1983; 19: 495-514.
    PubMedGoogle Scholar
  • 4 Krusińska E, Liebhart J, Woźniak M. A trial of predicting the histamine provocation dose during challenge test. In: Abstracts of the 10th International Meeting on Clinical Biostatistics. Maastricht; The Netherlands: September 1989: 74.
    Google Scholar
  • 5 Liebhart J, Krusińska E. Analysis of FEV1 changes during challenge test as the First step for constructing subsequent histamine concentration model. In: Scientific Contributions of the Institute of Electrical Metrology, Technical University of Wroclaw Series: Conferences No 14, 1988. 31 69-73. (in Polish).
    Google Scholar
  • 6 Späth H. Clusterwise linear least squares versus linear absolute deviations regression: a numerical comparison for a case study. In: Gaul W, Schader M. eds. Classification as a Tool of Research. Amsterdam: North-Holland; 1986: 413-22.
    Google Scholar
  • 7 Kamburoff PF, Woitowicz HI, Woitowicz RH. Prediction of spirometric indices. Resp News Bull 1973; 17: 1.
    PubMedGoogle Scholar
  • 8 Winer BJ. Statistical Principles in Experimental Design. London: McGraw Hill; 1970
    Google Scholar
  • 9 Plackett RL. Regression Analysis. Oxford: 1960
    Google Scholar
  • 10 Ralston A. A First Course in Numerical Analysis. New York: McGraw Hill; 1965
    Google Scholar
  • 11 Antoch J, Bartkowiak A, Pekalska J. Computing L1-norm, α-trimmed and a-win-sorized regression on the ODRA 1305 computer. Report N-159, Institute of Computer Science; University of Wroclaw: March 1986
    Google Scholar
  • 12 Barrodale J, Roberts FDK. An improved algorithm for discrete L1norm approximation. SIAM J Num Anal 1973; 10: 839-48.
    CrossrefPubMedGoogle Scholar
  • 13 Barrodale I, Roberts FDK. Solution of overdetermined system of equations in L1-norm. CADM 1974; 19: 319-20.
    PubMedGoogle Scholar
  • 14 Rao CR. Linear Statistical Inference and its Applications. New York: Wiley & Sons; 1965
    Google Scholar
  • 15 Liebhart J, Karkowski Z, Liebhart E, Mafolepszy J. Error characterization in spirometry and an attempt of classification. Probl Techn Med 1986; 17: 113-23. (in Polish).
    PubMedGoogle Scholar
  • 16 Senn SJ. The use of baselines in clinical trials of bronchodilators. Statist in Med 1989; 08: 1339-50.
    PubMedGoogle Scholar
  • 17 Senn SJ. Oral discussion to [4]. The 10th International Meeting on Clinical Biostatistics. Maastricht; The Netherlands: September 1989
    Google Scholar