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Nuklearmedizin 1993; 32(06): 288-291
DOI: 10.1055/s-0038-1632292
Originalarbeit
Schattauer GmbH

Influence of Blood Viscosity on Circulatory Parameters Determined by First-Pass Radionuclide Angiocardiography in Cor pulmonale

Einfluss der Blutviskosität auf die Kreislaufparameter bestimmt durch First-Pass-Radionuklid-Angiokardiographie in Cor pulmonale
Katalin Zámbó
1   From the Department of Nuclear Medicine
,
K. Tóth
2   1st Department of Medicine, Division of Cardiology University Medical School of Pécs, Hungary
› Author Affiliations
Further Information

Publication History

Received: 07 June 1993

26 July 1993

Publication Date:
03 February 2018 (online)

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Summary

First-pass radionuclide angiocardiography (FPRNA) with 99mTc-albumin was performed in 19 patients with cor pulmonale. Pulmonary circulation time (PCT), mean transit time (MTT), pulmonary stagnation index (PSI) were calculated from the time-activity curves for the estimation of cardiopulmonary circulation. Whole blood viscosity (WBV), plasma viscosity (PV) and hematocrit (HTC) were also measured on the same day. Significant prolongation of all parameters was observed (WBW: 5,04 ± 1.19 mPas; PV: 1,36 ± 0,17 mPas; HTC: 47,6 ±2,37%; PCT: 7,10 ± 2,15 s; MTT: 9,33 ±4,11 s; PSI: 1,30 ±0,37) in patients with cor pulmonale. Significant positive correlations were found between PCT and WBV (r = 0,552; 0,001 <P <0.01), MTT and WBV (r = 0,34; P <0,05), furthermore between PCT and HTC (r = 0,356; P <0,05). The results suggest that hemorheological parameters may influence the results of FPRNA, therefore, they should be determined in addition to the radionuclide study.

Zusammenfassung

Die First-Pass Untersuchung (FPRNA) mit 99mTc-Albumin wurde bei 19 Patienten mit Cor pulmonale durchgeführt. Pulmonale Zirkulationszeit (PCT), »mean transit« Zeit (MTT), pulmonaler Rest Index (PSI) wurden ermittelt aus den Zeit-Aktivitätskurven zur Einschätzung des kardiopulmonalen Durchflusses. Vollblut-Viskosität (WBV), Plasma-Viskosität (PV) und Hämatokrit (HTC) wurden am selben Tag gemessen. Bezeichnend für Patienten mit Cor pulmonale war eine typische Vergrößerung aller Parameter (WBV: 5,04 ± 1,19 mPAS; PV: 1,36 ± 0,17 mPAS; HTC: 47,6±2,37%; PCT: 7,10±2,15s; MTT: 9,33 ±4,11 s; PSI: 1,30 ±0,37). Verwertbare Korrelationen wurden zwischen PCT und WBV (r = 0,552; 0,001 <p <0,01), MTT und WBV (r = 0,34; p <0,05) sowie zwischen PCT und HTC (r = 0,356; p <0,05) gefunden. Die Resultate zeigen, daß hämorheologische Parameter einen Einfluß auf die Werte der FPRNA haben. Deswegen sollten diese Bestimmungen stets zusammen mit der FPRNA durchgeführt werden.

Key words

First-pass radionuclide angiocardiography - cardiopulmonary circulation - Cor pulmonale - blood rheology

Schlüsselwörter

First-pass Untersuchung - kardiopulmonaler Durchfluß - Cor pulmonale - BlutRheologie
 

  • References

  • 1 Aarts PAMM, Heuvelmans JHA, Gaslinga H. Blood viscosity evaluation by regression analysis to differenciate for hematocrit. Clin Hemorheol 1989; 09: 583-92.
    Google Scholar
  • 2 Adam WE, Geffers H, Siegel H, Bitter F, Kampmann H, Stauch M, Wassermann B. Evaluation of left ventricular function by radionuclide angiography. Herz 1977; 02: 195-9.
    Google Scholar
  • 3 Barbee JH, Cokelet GR. Prediction of blood flow in tubes with diameters as small as 29 1m. Microvasc Res 1971; 03: 17-21.
    CrossrefGoogle Scholar
  • 4 Begg TB, Hearus JB. Components in blood viscosity. Clin Sei 1966; 31: 87-93.
    Google Scholar
  • 5 Bisi G, Sciagra R, Büll V, Britton KE, Eilles C, Eißner O, Hahn K, Höffken H, Joseph K, McKillop J, Larock MP, Müller S, Reiners C, Rigo P. Assessment of ventricular function with first-pass radionuclide angiography using technetium 99m hexakis- 2-methoxyisobutylisonitrile: a European multicentre study. Eur J Nucl Med 1991; 18: 178-83.
    CrossrefGoogle Scholar
  • 6 Chien S. Haemorheology in disease, pathophysiological significance and therapeutic implications. Clin Hemorheol 1981; 01: 419-42.
    Google Scholar
  • 7 Chien S. Haemorheology in clinical medicine. Clin Hemorheol 1982; 02: 137-42.
    Google Scholar
  • 8 Dintenfass L. Viscosity factors in hypertensive and cardiovascular diseases. Cardiovasc Med 1977; 02: 337-54.
    Google Scholar
  • 9 Donato L, Rochester OF, Lewis L, Durand J, Parker JO, Harvey RM. Quantitative radiocardiography I. Theoretical considerations II. Technic and analysis of curves III. Results and validation of theory and method. Circulation 1962; 25: 674-86.
    CrossrefGoogle Scholar
  • 10 Dormandy JA. Measurement of whole- blood viscosity. In: Clinical Aspects of Blood Viscosity and Cell Deformability. Lowe GDO, Barbenel JC, Forbes CD. (eds). Berlin, Heidelberg, New York: Springer-Verlag; 1981: 67-78.
    Google Scholar
  • 11 Ehrly AM. On the relationship between microcirculation and hemorheology in clinical medicine: New aspects and strategies. Clin Hemorheol 1989; 09: 461.
    Google Scholar
  • 12 Pillay M, Rezvani M, Cox PH. Changes in pulmonary mean transit time demonstrated by the scintigraphic first pass technique in patients receiving radiation therapy. Eur J Nucl Med 1987; 13: 305-6.
    Google Scholar
  • 13 Schmid-Schönbein H. Interaction of vaso- motion and blood rheology in haemodyna- mics. In: Clinical Aspects of Blood Viscosity and Cell Deformability. Lowe GDO, Barbenel JC, Forbes CD. (eds). Berlin, Heidelberg, New York: Springer-Verlag; 1981: 49-66.
    Google Scholar
  • 14 Tóth K, Mezey B, Juricskay I, Jávor T. The role of hemorheological parameters in the cardiological differential diagnostics – especially in IHD and myocarditis. Clin Hemorheol 1989; 09: 529.
    Google Scholar
  • 15 Zámbó K, Nemessányi Z. Estimation of cardiopulmonary circulation using first-pass radionuclide angiography. Radiol diagn. 1993 34/1: 45-7.
    Google Scholar