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Nuklearmedizin 2000; 39(08): 218-231
DOI: 10.1055/s-0038-1632272
Original Article
Schattauer GmbH

Clinical applications of single photon emission tomography in neuromedicine

Part 2: dementia, psychotic disorders, inflammation, traumaKlinische Anwendungen der Single-Photon-Emissionstomographie in der NeuromedinTeil 2: Dementielle Erkrankungen, Psychosen, Entzündungen, Schädelhirntraumata
P. Bartenstein
1   Arbeitsgemeinschaft Neuronuklearmedizin der Deutschen Gesellschaft für Nuklearmedizin
,
F. Grünwald
1   Arbeitsgemeinschaft Neuronuklearmedizin der Deutschen Gesellschaft für Nuklearmedizin
,
T. Kuwert
1   Arbeitsgemeinschaft Neuronuklearmedizin der Deutschen Gesellschaft für Nuklearmedizin
,
K. Tatsch
1   Arbeitsgemeinschaft Neuronuklearmedizin der Deutschen Gesellschaft für Nuklearmedizin
,
O. Sabri
1   Arbeitsgemeinschaft Neuronuklearmedizin der Deutschen Gesellschaft für Nuklearmedizin
,
O. Benkert
1   Arbeitsgemeinschaft Neuronuklearmedizin der Deutschen Gesellschaft für Nuklearmedizin
,
R. Fahlbusch
1   Arbeitsgemeinschaft Neuronuklearmedizin der Deutschen Gesellschaft für Nuklearmedizin
,
G. Gründer
1   Arbeitsgemeinschaft Neuronuklearmedizin der Deutschen Gesellschaft für Nuklearmedizin
,
K. Herholz
1   Arbeitsgemeinschaft Neuronuklearmedizin der Deutschen Gesellschaft für Nuklearmedizin
,
C. Weiller
1   Arbeitsgemeinschaft Neuronuklearmedizin der Deutschen Gesellschaft für Nuklearmedizin
› Author Affiliations
Further Information

Publication History

Eingegangen: 25 July 2000

Publication Date:
01 February 2018 (online)

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Summary

This article gives in his second part a critical review of the clinical applications of SPECT with perfusion markers and receptor ligands in dementing disorders and psychosis. In addition this review discusses clinical applications of SPECT investigations with perfusion markers in inflammatory diseases of the central nervous system and in brain trauma.

Zusammenfassung

Die vorliegende Arbeit vermittelt in ihrem zweiten Teil eine kritisch wertende Übersicht über die klinischen Anwendungsmöglichkeiten von SPECT-Untersuchungen mit Perfusionsmarkern und Rezeptorliganden bei dementieilen Erkrankungen sowie affektiven und schizophrenen Psychosen. Darüber hinaus werden in dieser Übersicht Anwendungen von SPECT-Untersuchungen mit Perfusionsmarkern bei Fragestellungen im Rahmen von Entzündungen des zentralen Nervensystems und bei Schädelhirntraumata diskutiert.

Keywords

Single photon emission tomography (SPECT) - dementia - schizophrenia - depression - brain trauma - inflammation

Schlüsselwörter

Single-Photon-Emissionstomographie (SPECT) - Demenz - Schizophrenie - Depression - Schädelhirntrauma - Entzündung
 

  • Literatur

  • 1 Abdel-Dayem HM, Abu-Judeh H, Kumar M, Atay S, Naddaf S, El-Zeftawy H, Luo JQ. SPECT brain perfusion abnormalities in mild or moderate traumatic brain injury. Clin Nucl Med 1998; 23: 309-17.
    CrossrefPubMedSearch in Google Scholar
  • 2 Abi-Dargham A, Laruelle M, Krystal J, D’Souza C, Zoghbi S, Baldwin RM, Seibyl J, Mawlawi O, de Erasquin G, Charney D, Innis RB. No evidence of altered in vivo benzodiazepine receptor binding in schizophrenia. Neuropsychopharmacology 1999; 20: 650-61.
    CrossrefPubMedSearch in Google Scholar
  • 3 Aharon-Peretz J, Peretz A, Hemli JA, Honigman S, Israel O. SPECT diagnosis of Creutzfeldt-Jakob disease. J Nucl Med 1995; 36: 616-7.
    PubMedSearch in Google Scholar
  • 4 Ajmani A, Habte-Gabr E, Zarr M, Jayabalan V, Dandala S. Cerebral blood flow SPECT with Te-99m exametazime correlates in AIDS dementia complex stages. A preliminary report. Clin Nucl Med 1991; 16: 656-9.
    CrossrefPubMedSearch in Google Scholar
  • 5 Albin RL, Minoshima S, Di’Amato CJ, Frey KA, Kühl DA, Sima AA. Fluoro-deoxyglucose positron emission tomography in diffuse Lewy body disease. Neurology 1996; 47: 462-6.
    CrossrefPubMedSearch in Google Scholar
  • 6 Andreasen NC, O’Leary DS, Flaum M. et al. Hypofrontality in schizophrenia: Distributed dysfunctional circuits in neuroleptic-naive patients. Lancet 1997; 349: 1730-4.
    CrossrefPubMedSearch in Google Scholar
  • 7 Attar-Lévy D, Martinot JL, Blin J. et al. The cortical serotonin2 receptors studied with positron-emission tomography and [18F]-setoperone during depressive illness and antidepressant treatment with clomipramine. Biol Psychiatry 1999; 45: 180-6.
    CrossrefPubMedSearch in Google Scholar
  • 8 Awada HH, Mamo HL, Luft AG, Ponsin JC, Kahn MF. Cerebral blood flow in systemic lupus erythematosus with and without central nervous system involvement. J Neurol Neurosurg Psychiatry 1987; 50: 1597-601.
    CrossrefPubMedSearch in Google Scholar
  • 9 Awata S, Ito H, Konno M. et al. Regional cerebral blood flow abnormalities in late-life depression: Relation to refractoriness and chronification. Psychiatry Clin Neurosci 1998; 52: 97-105.
    CrossrefPubMedSearch in Google Scholar
  • 10 Ball S, Busatto GF, David AS. et al. Cognitive functioning and GABAA/benzodiazepine receptor binding in schizophrenia: A 1231-iomazenil SPET study. Biol Psychiatry 1998; 43: 107-17.
    CrossrefPubMedSearch in Google Scholar
  • 11 Bartenstein P, Koepp M. Benzodiazepinrezeptor-Darstellung mit Positronen-Emissionstomographie und Single-Photon-Emissionstomographie Nervenarzt. 1995; 66: 412-21.
    PubMedSearch in Google Scholar
  • 12 Bartenstein P, Minoshima S, Hirsch C, Buch K, Willoch F, Mösch D, Schad D, Schwaiger M, Kurz A. Quantitative assessment of cerebral blood flow in patients with Alzheimer’s disease by single photon emission computed tomography. Nucl Med 1997; 38: 1095-101.
    Search in Google Scholar
  • 13 Bavetta S, Nimmon CC, White J, McCabe J, Huneidi AH, Bomanji J, Birkenfeld B, Charlsworth M, Britton KE, Greenwood RJ. A prospective study comparing SPET with MRI and CT as prognostic indicators following severe closed head injury. Nucl Med Commun 1994; 15: 961-8.
    CrossrefPubMedSearch in Google Scholar
  • 14 Baxter Jr. LR, Schwartz JM, Phelps ME. et al. Reduction of prefrontal cortex glucose metabolism common to three types of depression. Arch Gen Psychiatry 1989; 46: 243-50.
    CrossrefPubMedSearch in Google Scholar
  • 15 Bench CJ, Frackowiak RS, Dolan RJ. Changes in regional cerebral blood flow on recovery from depression. Psychol Med 1995; 25: 247-61.
    CrossrefPubMedSearch in Google Scholar
  • 16 Benkert O, Hippius H. Kompendium der Psychiatrischen Pharmakotherapie. 2. Aufl.. 2000. Springer; Heidelberg:
    Search in Google Scholar
  • 17 Benson DF, Djenderdjian A, Miller BL, Pachana NA, Chang L, Itti L, Mena I. Neural basis of confabulation. Neurology 1996; 46: 1239-43.
    CrossrefPubMedSearch in Google Scholar
  • 18 Bergström KA, Halldin C, Savonen A, Okubo Y, Hiltunen J, Nobuhara K, Swahn CG, Karlsson P, McPherson D, Knapp FF, Larsson S, Schnell PO, Farde L. Iodine-123 labelled Z-(R.R)-IQNP: a potential radioligand for visualization of M(1)and M(2) muscarinic acetylcholine receptors in Alzheimer’s disease. Eur J Nucl Med 1999; 26: 1482-5.
    CrossrefPubMedSearch in Google Scholar
  • 19 Biver F, Wikler D, Lotstra F, Damhaut P, Goldman S, Mendlewicz J. Serotonin 5-HT2 receptor imaging in major depression: Focal changes in orbito-insular cortex. Br J Psychiatry 1997; 171: 444-8.
    CrossrefPubMedSearch in Google Scholar
  • 20 Bonne O, Krausz Y, Shapira B. et al. Increased cerebral blood flow in depressed patients responding to electroconvulsive therapy. J Nucl Med 1996; 37: 1075-80.
    PubMedSearch in Google Scholar
  • 21 Breitner JC, Jarvik GP, Plassman BL, Saunders AM, Welsh KA. Risk of Alzheimer disease with the epsilon4 allele for apolipoprotein E in a population-based study of men aged 62-73 years. Alzheimer Dis Assoc Disord 1998; 12: 40-4.
    CrossrefPubMedSearch in Google Scholar
  • 22 Brodie JD, Christman DR, Corona JF. et al. Patterns of metabolic activity in the treatment of schizophrenia. Ann Neurol 1984; 15: 166-69.
    CrossrefPubMedSearch in Google Scholar
  • 23 Broich K, Grünwald F, Kasper S, Klemm E, Biersack HJ, Möller HJ. D2-dopamine receptor occupancy measured by 1BZM-SPECT in relation to extrapyramidal side effects. Pharmacopsychiatry 1998; 31: 159-62.
    Thieme ConnectPubMedSearch in Google Scholar
  • 24 Brun A. Frontal lobe degeneration of non-Alzheimer type revisited Dementia. 1993; 4: 126-31.
    PubMedSearch in Google Scholar
  • 25 Buchsbaum MS, Ingvar DH, Kessler R. et al. Cerebral glucography with positron tomography. Use in normal subjects and in patients with schizophrenia. Arch Gen Psychiatry 1982; 39: 251-9.
    CrossrefPubMedSearch in Google Scholar
  • 26 Buchsbaum MS, Wu JC, DeLisi LE. et al. Frontal cortex and basal ganglia metabolic rates assessed by positron emission tomography with [18F]2-deoxyglucose in affective illness. J Affect Disord 1986; 10: 137-52.
    CrossrefPubMedSearch in Google Scholar
  • 27 Buchsbaum MS, Hazlett EA. Positron emission tomography studies of abnormal glucose metabolism in schizophrenia. Schizophr Bull 1998; 24: 343-64.
    CrossrefPubMedSearch in Google Scholar
  • 28 Busatto GF, Pilowsky LS, Costa DC. et al. Correlation between reduced in vivo benzodiazepine receptor binding and severity of psychotic symptoms in schizophrenia. Am J Psychiatry 1997; 154: 56-63. [Erratum in: Am J Psychiatry 1997:154:722.]
    CrossrefPubMedSearch in Google Scholar
  • 29 Buttner A, Mehraein P, Weis S. Vascular changes in the cerebral cortex in HIV-1 infection. II. An immunohistochemical and lectinhistochemical investigation. Acta Neurophysiol 1996; 92: 35-41.
    Search in Google Scholar
  • 30 Caparros-Lefèbvre D, Girard-Buttaz I, Reboul S. et al. Cognitive and psychiatric impairment in herpes simplex virus encephalitis suggest involvement of the amygdalo-frontal pathways. J Neurol 1996; 243: 248-56.
    CrossrefPubMedSearch in Google Scholar
  • 31 Carette S, Urowitz M, Grossman H, Louis St. E. Cranial computerized tomography in systemic lupus erythematosus. J Rheumatol 1982; 9: 855-59.
    Search in Google Scholar
  • 32 Catafau AM, Parellada E, Lomena FJ. et al. Prefrontal and temporal blood flow in schizophrenia. J Nucl Med 1994; 35: 935-41.
    PubMedSearch in Google Scholar
  • 33 Catafau AM, Sola M, Lomena FJ, Guelar A, Miro JM, Setoâin J. Hyperperfusion and early technetium-99m-HMPAO SPECT appearance of central nervous system toxoplasmosis. J Nucl Med 1994; 35: 1041-3.
    PubMedSearch in Google Scholar
  • 34 Cleghorn JM, Garnett ES, Nahmias C. et al. Increased frontal and reduced parietal glucose metabolism in acute untreated schizophrenia. Psychiatry Res 1989; 28: 119-133.
    CrossrefPubMedSearch in Google Scholar
  • 35 Cohen HCM, Semple WE, Gross N. et al. Evidence for common alterations in cerebral glucose metabolism in major affective disorders and schizophrenia. Neuropsychopharmacology 1989; 2: 241-54.
    CrossrefPubMedSearch in Google Scholar
  • 36 Coppens HJ, Slooff CJ, Paans AM, Wiegman T, Vaalburg W, Korf J. High central D2-dopamine receptor occupancy as assessed with positron emission tomography in medicated but therapy-resistant schizophrenic patients. Biol Psychiatry 1991; 29: 629-34.
    CrossrefPubMedSearch in Google Scholar
  • 37 Davis WK, Mirra SS, Alazraki N. The brain in older persons with and without dementia: findings on MR. PET, and SPECT images. Am J Roentgenol 1994; 162: 1267-78.
    CrossrefPubMedSearch in Google Scholar
  • 38 De Deyn PP, Van den Broucke PW, Pickut BA. et al. Perfusion and thallium single photon emission computed tomography in herpes simplex encephalitis. J Neurological Sei 1998; 157: 96-99.
    Search in Google Scholar
  • 39 De Jong BM, Pruim J, Sinnige LG. et al. Regional specific changes of cerebral metabolism in systemic lupus erythematosus identified by positron emission tomography. Eur Neurology 1999; 41: 187-93.
    Search in Google Scholar
  • 40 Della-Corte F, Giordano A, Pennisi MA, Barelli A, Caricato A, Campioni P, Galli G. Quantitative cerebral blood flow and metabolism determination in the first 48 hours after severe head injury with a new dynamic SPECT device. Acta Neurochir Wien 1997; 139: 636-41.
    CrossrefPubMedSearch in Google Scholar
  • 41 De Leon MJ, Convit A, DeSanti S, Bobinski M, George AE, Wisniewski HM, Rusinek H, Carroll R, Saint Louis LA. Contribution of structural neuroimaging to the early diagnosis of Alzheimer’s disease. Int Psychogeriatr 1997; 9 (Suppl. 01) 183-l90.
    PubMedSearch in Google Scholar
  • 42 De Lisi LE, Buchsbaum MS, Holcomb HH. et al. Clinical correlates of decreased anteroposterior metabolic gradients in positron emission tomography of schizophrenic patients. Am J Psychiatry 1985; 142: 78-81.
    CrossrefPubMedSearch in Google Scholar
  • 43 Depas G, Chiron C. Tardieu. et al. Functional brain imaging in HIV-1 infected children born to seropositive mothers. J Nucl Med 1995; 36: 2169-74.
    PubMedSearch in Google Scholar
  • 44 Devous Sr. MD, Paulman RG, Herman J. et al. Single-photon emission tomography studies with schizophrenic patients. J Clin Exp Neuropsychol 1988; 10: 321-2.
    Search in Google Scholar
  • 45 Dilling H, Mombour W, Schmidt MH. Internationale Klassifikation psychischer Störungen. ICD-10 Kapitel V (F). Klinisch-diagnostische Leitlinien. Bern, Göttingen, Toronto, Seattle: Verlag Hans Huber; 1994
    Search in Google Scholar
  • 46 Dolan RJ, Bench CJ, Brown RG, Scott LC, Frackowiak RSJ. Neuropsychological dysfunction in depression: The relationship to regional cerebral blood flow. Psychol Med 1994; 24: 849-57.
    CrossrefPubMedSearch in Google Scholar
  • 47 Donnemiller E, Heilmann J, Wenning GK, Berger W, Decristoforo C, Moncayo R, Poewe W, Ransmayer G. Brain perfusion scintigraphy with 99m-Tc-HMPAO or 99m-Tc-ECD and 123-I-beta-CIT single-photon emission tomography in dementia os the Alzheimer-type and diffuse Lewy body disease. Eur J Nucl Med 1997; 24: 320-5.
    PubMedSearch in Google Scholar
  • 48 Dresel S, Tatsch K, Dahne I, Mager T, Scherer J, Hahn K. Iodine-123-iodobenzamide SPECT assessment of dopamine D2 receptor occupancy in risperidone-treated schizophrenic patients. J Nucl Med 1998; 39: 1138-42.
    PubMedSearch in Google Scholar
  • 49 Dresel S, Mager T, Rossmüller B, Meisenzahl E. et al. In vivo effects of olanzapine on striatal dopamine D2/D3 receptor binding in schizophrenic patients: an iodine-123 iodobenzamide single-photon emission tomography study. Eur J Nucl Med 1999; 26: 862-8.
    CrossrefPubMedSearch in Google Scholar
  • 50 Drevets WC, Price JL, Simpson Jr. JR. et al. Subgenual prefrontal cortex abnormalities in mood disorders. Nature 1997; 386: 824-7.
    CrossrefPubMedSearch in Google Scholar
  • 51 Ebadi M, Pfeiffer RF, Murrin LC. Pathogenesis and treatment of NMS. Gen Pharmacol 1990; 21: 367-86.
    CrossrefPubMedSearch in Google Scholar
  • 52 Ebert D, Feistel H, Barocka A, Kaschka W. Increased limbic blood flow and total sleep deprivation in major depression with melancholia. Psychiatry Res Neuroimaging 1994; 55: 101-9.
    CrossrefPubMedSearch in Google Scholar
  • 53 Ebert D, Feistel H, Loew T, Pirner A. Dopamine and depression – striatal dopamine D2 receptor SPECT before and after antidepressant therapy. Psychopharmacology Berl 1996; 126: 91-4.
    CrossrefPubMedSearch in Google Scholar
  • 54 Farde L, Wiesel FA, Stone-Elander S. et al. D2 dopamine receptors in neuroleptic-naive schizophrenic patients. A positron emission tomography study with [11C]raclopride. Arch Gen Psychiatry 1990; 47: 213-9.
    CrossrefPubMedSearch in Google Scholar
  • 55 Farde L, Nordstrom AL, Wiesel FA, Pauli S, Halldin C, Sedvall G. Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects. Arch Gen Psychiatry 1992; 49: 538-44.
    CrossrefPubMedSearch in Google Scholar
  • 56 Fazekas F, Roob G, Payer F, Kapeller P, Strasser-Fuchs S, Aigner RM. Technetium-99m-ECD SPECT fails to show focal hyperemia of acute herpes encephalitis. J Nucl Med 1998; 39: 790-2.
    PubMedSearch in Google Scholar
  • 57 Förstl H. Lehrbuch der Gerontopsychiatrie. Enke: Stuttgart; 1997
    Search in Google Scholar
  • 58 Geldmacher DS, Whitehouse PJ. Evaluation of Dementia. New Engl J Med 1996; 335: 330-6.
    CrossrefPubMedSearch in Google Scholar
  • 59 Gerlach J, Lublin H, Peacock L. Extrapyramidal symptoms during long-term treatment with antipsychotics: Special focus on clozapine and D1 and D2 dopamine antagonists. Neuropsychopharmacology 1996; 14 (Suppl. 03) 35-39
    CrossrefPubMedSearch in Google Scholar
  • 60 Goldman S, Laird A, Flament-Durand J. et al. Positron emission tomography and histopathology in Creutzfeldt-Jakob disease. Neurology 1993; 43: 1828-30.
    CrossrefPubMedSearch in Google Scholar
  • 61 Goodwin GM. Functional imaging, affective disorder and dementia. Br Med Bull 1996; 52: 495-512.
    CrossrefPubMedSearch in Google Scholar
  • 62 Goodwin GM. Neuropsychological and neuroimaging evidence for the involvement of the frontal lobes in depression. J Psychopharmacol 1997; 11: 115-122.
    CrossrefPubMedSearch in Google Scholar
  • 63 Goto I, Taniwaki T, Hosokawa S, Otsuka M, Ichiya Y, Ichimiya A. Positron emission tomographic (PET) studies in dementia. J Neurological Sei 1993; 114: 1-6.
    Search in Google Scholar
  • 64 Gray BG, Ichise M, Chung DG, Kirsh JC, Franks W. Technetium-99m-HMPAO-SPECT in the evaluation of patients with a remote history of traumatic brain injury a comparison with x-ray computed tomography. J Nucl Med 1992; 33: 52-8.
    PubMedSearch in Google Scholar
  • 65 Gregory CA, Serra-Mestres J, Hodges JR. Early diagnosis of the frontal variant of frontotemporal dementia: how sensitive are standard neuroimaging and neuropsychologic tests?. Neuropsychiatry Neuropsychol Behav Neurol 1999; 12: 128-35.
    PubMedSearch in Google Scholar
  • 66 Gründer G, Yokoi F, Offord SJ, Ravert HT, Dannals RF, Salzmann JK, Szymanski S, Wilson PD, Howard DR, Wong DF. Time after a single oral dose of the putative antipsychotic drug MDL 100,907 measured by positron emission tomography. Neuropsychopharmacology 1997; 17: 175-185.
    CrossrefPubMedSearch in Google Scholar
  • 67 Gründer G, Müller MJ, Andreas J, Wetzel H, Heydari N, Schlösser R, Schlegel S, Nickel O, Eissner D, Benkert O. Occupancy of striatal D2-like dopamine receptors after treatment with the sigma ligand EMD 57445, a putative atypical antipsychotic. Psychopharmacology 1999; 146: 81-86.
    CrossrefPubMedSearch in Google Scholar
  • 68 Grünwald F, Nadstawek J, Ostertun B, Briele B, Bockisch A, Hotze A, van Roost D, Biersack HJ. Imaging cerebral blood flow with Technetium-99m HMPAO after head injury associated with consecutive transitional appalic syndrome. Radiol Diagn 1992; 33: 215-20
    Search in Google Scholar
  • 69 Grünwald F, Schomburg A, Badali A, Ruhlmann J, Pâvics L, Biersack HJ. 18FDG PET and acetazolamide-enhanced 99mTc-HMPAO SPET in systemic lupus erythematosus. Eur J Nucl Med 1995; 22: 1073-7.
    CrossrefPubMedSearch in Google Scholar
  • 70 Grünwald F, Pohl C, Bender H. et al. 18F-fluorodeoxyglucose-PET and 99mTc-bicisate-SPECT in Creutzfeldt-Jakob disease. Ann Nucl Med 1996; 10: 131-4.
    CrossrefPubMedSearch in Google Scholar
  • 71 Gustafson L. Clinical picture of frontal lobe degeneration of non-Alzheimer type Dementia. 1993; 4: 143-8.
    PubMedSearch in Google Scholar
  • 72 Häfner H, Maurer K, Löffler W, Riecher-Rössler A. The influence of age and sex on the onset and early course of schizophrenia. Br J Psychiatry 1993; 162: 80-6.
    CrossrefPubMedSearch in Google Scholar
  • 73 Hanyu H, Sakurai H, Iwamoto T, Takasaki M, Shindo H, Kakizaki D, Abe K. Regional differences in diffusion abnormality in cerebral white matter lesions in patients with vascular dementia of the Binswanger type and Alzheimer’s disease. Eur J Neurol 1999; 6: 195-203.
    CrossrefPubMedSearch in Google Scholar
  • 74 Hashikawa K, Matsumoto M, Moriwaki H, Oku N, Okazaki Y, Seike Y, Uehara T, Tanabe H, Ohie Y, Kamada T. Three-dimensional display of surface cortical perfusion by SPECT: application in assessing Alzheimer’s disease. J Nucl Med 1995; 36: 690-6.
    PubMedSearch in Google Scholar
  • 75 Heinz A, Knäble MB, Weinberger DR. Dopamine D2 receptor imaging and neuroleptic drug response. J Clin Psychiatry 1996; 57 (Suppl. 11) 84-93.
    PubMedSearch in Google Scholar
  • 76 Herholz K, Perani D, Salmon E, Franck G, Fazio F, Heiss WD, Comar D. Comparability of FDG PET studies in probable Alzheimer’s disease. J Nucl Med 1993; 34: 1460-6.
    PubMedSearch in Google Scholar
  • 77 Herholz K. FDG PET and differential diagnosis of dementia. Alzheimer’s Dis Associated Disord 1995; 9: 6-16.
    Search in Google Scholar
  • 78 Hinkin CH, van Gorp WG, Mandelkern MA. et al. Cerebral metabolic change in patients with AIDS: Report of a six-month follow-up using positron-emission tomography. J Neuropsychiatry Clin Neurosci 1995; 7: 180-7.
    CrossrefPubMedSearch in Google Scholar
  • 79 Hiraiwa M, Nonaka C, Abe T, Iio M. Positron emission tomography in systemic lupus erythematosus: Relation of cerebral vasculitis to PET findings. Am J Neuroradiol 1983; 4: 541-3.
    PubMedSearch in Google Scholar
  • 80 Hirono N, Mori E, Ishii K. et al. Frontal lobe hypometabolism and depression in Alzheimer’s disease. Neurology 1998; 50: 380-3.
    CrossrefPubMedSearch in Google Scholar
  • 81 Hofman A, Rocca WA, Brayne C, Breteler MM, Clarke M, Cooper B, Copeland JR, Dartigues JF, da Silva-Droux A, Hagnell O. The prevalence of dementia in Europe: A collaborative study of 1980-1990 findings. Int J Epidemiol 1991; 20: 736-48
    CrossrefPubMedSearch in Google Scholar
  • 82 Holman BL, Johnson KA, Gerada B, Carvalho PA, Satlin A. The Szintigraphie appearance of Alzheimer’s disease: a prospective study using technetium-99m-HMPAO SPECT. J Nucl Med 1992; 33: 181-5.
    PubMedSearch in Google Scholar
  • 83 Holman BL, Garada B, Johnson KA. et al. A comparison of brain perfusion SPECT in cocaine abuse and AIDS dementia complex. J Nucl Med 1992; 33: 1312-5.
    PubMedSearch in Google Scholar
  • 84 Holthoff VA, Beuthien-Baumann B, Pietrzyk U, Pinkert J, Oehme L, Franke WG, Bach O. Regionale Funktionsstörung bei der Depression. Hirn-SPECT zur Verlaufskontrolle. Nervenarzt 1999; 70: 620-6.
    CrossrefPubMedSearch in Google Scholar
  • 85 Huang JL, Yeh KW, You DL, Hsieh KH. Serial single photon emission computed tomography imaging in patients with cerebral lupus during acute exacerbation and after treatment Pediatric Neurology. 1997; 17: 44-8.
    PubMedSearch in Google Scholar
  • 86 Hunter R. Frontal metabolic deficits in Korsakoff syndrome. Br J Psychiatry 1990; 157: 454-5.
    PubMedSearch in Google Scholar
  • 87 Ichiyama T, Nishikawa M, Hayashi T, Koga M, Tashiro N, Furukawa S. Cerebral hypoperfusion during acute Kawasaki disease. Stroke 1998; 29: 1320-1.
    CrossrefPubMedSearch in Google Scholar
  • 88 Ishii K, Yamaji S, Kitagaki H, Imamura T, Hirono N, Mori E. Regional cerebral blood flow difference between dementia with Lewy bodies and AD Neurology. 1999; 53: 413-6.
    PubMedSearch in Google Scholar
  • 89 Itoh Y, Amano T, Shimizu T, Hashimoto J, Kubo A, Fukuuchi Y. Single-photon emission computed tomography image of benzodiazepine receptors in a patient with Creutzfeldt-Jakob disease. Internal Med 1998; 37: 896-900.
    CrossrefPubMedSearch in Google Scholar
  • 90 Jacobs A, Put E, Ingels M, Bossuyt A. Prospective evaluation of technetium-99m-HMPAO SPECT in mild and moderate traumatic brain injury. J Nucl Med 1994; 35: 942-47.
    PubMedSearch in Google Scholar
  • 91 Jacobs A, Put E, Ingels M, Put T, Bossuyt A. One-year follow-up of technetium-99m-HMPAO SPECT in mild head injury. J Nucl Med 1996; 37: 1605-9.
    PubMedSearch in Google Scholar
  • 92 Jagust WJ. Functional imaging patterns in Alzheimer’s disease. Relationship to neurobiology. Ann NY Acad Sei 1996; 777: 22-9.
    CrossrefPubMedSearch in Google Scholar
  • 93 Jauss M, Krack P, Franz M. et al. Imaging of dopamine receptors with [123I]Iodobenzamide single-photon emission-computed tomography in neuroleptic malignant syndrome. Movement Disorders 1996; 11: 726-8.
    CrossrefPubMedSearch in Google Scholar
  • 94 Jibiki I, Fukushima T, Kobayashi K. et al. Utility of 123I-IMP SPECT brain scans for the early detection of site-specific abnormalities in Creutzfeldt-Jakob disease (Heidenhain type): A case study. Neuropsychobiology 1994; 29: 117-9.
    CrossrefPubMedSearch in Google Scholar
  • 95 Jobst KA, Smith AD, Barker CS, Wear A, King EM, Smith A, Anslow PA, Molyneux AJ, Shepstone BJ, Soper N. Association of atrophy of the medial temporal lobe with reduced blood flow in the posterior parietotemporal cortex in patients with a clinical and pathological diagnosis of Alzheimer’s disease. J Neurol Neurosurg Psychiatry 1992; 55: 190-4.
    CrossrefPubMedSearch in Google Scholar
  • 96 Jobst KA, Barnetson LP, Shepstone BJ. Accurate prediction of histologically confirmed Alzheimer’s disease and the differential diagnosis of dementia: the use of NINCDS-ADRDA and DSM-III-R criteria. SPECT X-ray CT, and Apo E4 in medial temporal lobe dementias. Oxford Project to Investigate Memorv and Aging. Int Psychogeriatr 1998; 10: 271-302.
    CrossrefPubMedSearch in Google Scholar
  • 97 Johnson KA, Kijewski MF, Becker A, Garada B, Satlin A, Holman BL. Quantitative brain SPECT in Alzheimer’s disease and normal aging. J Nucl Med 1993; 34: 2044-8.
    PubMedSearch in Google Scholar
  • 98 Jorm AF, Korten AE, Henderson AS. The prevalence of dementia: A quantitative integration of the literature. Acta Psvchiat Scand 1987; 76: 465-79.
    Search in Google Scholar
  • 99 Kao CH, Wang SJ, Mak SC, Shian WJ, Chi CS. Viral encephalitis in children: Detection with technetium-99m HMPAO brain single-photon emission CT and its value in prediction of outcome. Am J Neuroradiol 1994; 15: 1369-73.
    PubMedSearch in Google Scholar
  • 100 Kao CH, Chan JL, Chang Lai SP, Liao KK, Yen RF, Chieng PU. The role of FDG-PET. HMPAO-SPET and MRI in the detection of brain involvement in patients with systemic lupus erythematosus. Eur J Nucl Med 1999; 26: 129-34.
    CrossrefPubMedSearch in Google Scholar
  • 101 Kao CH, Ho YJ, Lan JL, Chang Lai SP, Liao KK, Chieng PU. Discrepancy between regional cerebral blood flow and glucose metabolism of the brain in systemic lupus erythematosus patients with normal brain magnetic resonance imaging findings. Arthritis Rheum 1999; 42: 61-68.
    CrossrefPubMedSearch in Google Scholar
  • 102 Kapur S, Remington G, Zipursky RB, Wilson AA, Houle S. The D2-dopamine receptor occupancy of risperidone and its relationship to extrapyramidal symptoms: A PET study. Life Sei 1995; 57: 103-7.
    CrossrefPubMedSearch in Google Scholar
  • 103 Kapur S, Zipursky RB, Remington G. et al. 5-HT2 and D2 receptor occupancy of olanzapine in schizophrenia: A PET studv. Am J Psychiatry 1998; 155: 921-928.
    CrossrefPubMedSearch in Google Scholar
  • 104 Kapur S, Zipursky RB, Remington G. Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone and olanzapine in schizophrenia. Am J Psvchiatry 1999; 156: 286-93.
    Search in Google Scholar
  • 105 Kim DM, Tien R, Byrum C, Krishnan KR. Imaging in acquired immune deficiency syndrome dementia complex (AIDS dementia complex): A review. Prog Neuro-Psychopharmacol Biol Psychiatry 1996; 20: 349-70.
    CrossrefPubMedSearch in Google Scholar
  • 106 Kimura K, Dosaka A, Hashimoto Y, Yasunaga T, Uchino M, Ando M. Single-photon emission CT findings in acute Japanese encephalitis. Amer J Neuroradiol 1997; 18: 465-9.
    Search in Google Scholar
  • 107 Klemm E, Danos P, Grünwald F, Kasper S, Möller HJ, Biersack HJ. Temporal lobe dysfunction and correlation of regional cerebral blood flow abnormalities with psychopathology in schizophrenia and major depression – a tomography. Psychiatry Res 1996; 68: 1-10.
    CrossrefPubMedSearch in Google Scholar
  • 108 Klemm E, Grünwald F, Kasper S. et al. [123]IBZM SPECT for imaging of striatal D2 dopamine receptors in 56 schizophrenic patients taking various neuroleptics. Am J Psychiatry 1996; 153: 183-90.
    CrossrefPubMedSearch in Google Scholar
  • 109 Klimke A, Larisch R, Janz A, Vosberg H, Müller-Gärtner HW, Gaebel W. Dopamine D2 receptor binding before and after treatment with major depression measured by [1231] 1BZM. Psychiatry Res 1999; 90: 91-101.
    CrossrefPubMedSearch in Google Scholar
  • 110 Kling AS, Metter EJ, Riege WH, Kühl DE. Comparison of PET measurement of local brain glucose metabolism and CAT measurement of brain atrophy in chronic schizophrenia and depression. Am J Psychiatry 1986; 143: 175-80.
    CrossrefPubMedSearch in Google Scholar
  • 111 Kocmur M, Milcinski M, Budihna NV. Evaluation of brain perfusion with technetium-99m bicisate single-photon emission tomography in patients with depressive disorder before and after drug treatment. Eur J Nucl Med 1998; 25: 1412-4.
    CrossrefPubMedSearch in Google Scholar
  • 112 Komatsu N, Kodama K, Yamanouchi N. et al. Decreased regional cerebral metabolic rate for glucose in systemic lupus erythematosus patients with psychiatric symptoms. Eur Neurology 1999; 42: 41-48.
    Search in Google Scholar
  • 113 Koväcs JA, Urowitz MB, Gladman DD, Zeman R. The use of single photon emission computed tomography in neuropsychiatrie SLE: A pilot study. J Rheumatol 1995; 22: 1247-53.
    Search in Google Scholar
  • 114 Kramer EL, Sanger JJ. Brain imaging in acquired immunodeficiency syndrome dementia complex. Seminars Nucl Med 1990; 20: 353-63.
    Search in Google Scholar
  • 115 Kühl DE, Minoshima S, Fessier JA, Frey KA, Foster NL, Ficaro EP, Wieland DM, Koeppe RA. In vivo mapping of cholinergic terminals in normal aging, Alzheimers disease and Parkinson’s disease. Ann Neurol 1996; 40: 399-410.
    CrossrefPubMedSearch in Google Scholar
  • 116 Kukull WA, Larson EB, Reifler BV, Lampe TH, Yerby MS, Hughes JP. The validity of 3 clinical criteria for Alzheimer’s disease. Neurology 1990; 40: 1364-9.
    CrossrefPubMedSearch in Google Scholar
  • 117 Kurz A, Riemenschneider M, Buch K, Willoch F, Bartenstein P, Müller U, Guder W. Tau protein in cerebrospinal fluid is significantly increased at the earliest clinical stage of Alzheimer’s disease. Alz Dis Assoc Dis 1998; 12 (1998) 372-7.
    CrossrefPubMedSearch in Google Scholar
  • 118 Kuwert T, Lange HW, Langen KJ, Herzog H, Aulich A, Feinendegen LE. Cortical and subcortical glucose consumption measured by PET in patients with Huntington’s disease. Brain 1990; 113: 1405-23.
    CrossrefPubMedSearch in Google Scholar
  • 119 Kuwert T, Bartenstein P, Grünwald F, Herholz K, Larisch R, Sabri O, Biersack H-J, Moser E, Müller-Gärtner H-W, Schober O, Schwaiger M, Büll U, Heiss W-D. Klinische Wertigkeit der Positronen-Emissions-Tomographie in der Neuromedizin: Positionspapier zu den Ergebnissen einer interdisziplinären Konsensuskonferenz. Nervenarzt 1998; 69: 1045-60.
    CrossrefPubMedSearch in Google Scholar
  • 120 Kushner MJ, Tobin M, Fazekas F. et al. Cerebral blood flow variations in CNS lupus. Neurology 1990; 40: 99-102.
    CrossrefPubMedSearch in Google Scholar
  • 121 Larisch R, Klimke A, Vosberg H, Löffler S, Gaebel W, Müller-Gärtner HW. In vivo evidence for the involvement of dopamine-D2 receptors in striatum and anterior cingulate gyrus in major depression. Neuroimage 1997; 5: 251-60.
    CrossrefPubMedSearch in Google Scholar
  • 122 Larisch R, Klimke A. Clinical impact of cerebral dopamine-D2 receptor scintigraphy. Nuklearmedizin 1998; 37: 245-50.
    Thieme ConnectPubMedSearch in Google Scholar
  • 123 Laruelle M. Imaging dopamine transmission in schizophrenia. A review and meta-analysis. OJ Nucl Med 1998; 42: 211-21.
    Search in Google Scholar
  • 124 Launes J, Siren J, Valanne L, Salonen O, Nikkinen P, Seppäläinen AM. Unilateral hyperperfusion in brain-perfusion SPECT predicts poor prognosis in acute encephalitis. Neurology 1997; 48: 1347-51.
    CrossrefPubMedSearch in Google Scholar
  • 125 Lewis R, Kapur S, Jones C. et al. Serotonin 5-HT2 receptors in schizophrenia: A PET study using [18F]setoperone in neurolepticnaive patients and normal subjects. Am J Psychiatry 1999; 156: 72-8.
    CrossrefPubMedSearch in Google Scholar
  • 126 Lewis SW, Ford RA, Syed GM, Reveley AM, Toone BU. A controlled study of 99mTc-HMPAO single-photon emission imaging in chronic schizophrenia. Psychol Med 1992; 22: 27-35.
    CrossrefPubMedSearch in Google Scholar
  • 127 Lieberman JA, Mailman RB, Duncan G, Sikich L, Chakos M, Nichols DE, Kraus JE. Serotonergic basis of antipsychotic drug effects in schizophrenia. Biol Psychiatry 1998; 44: 1099-1117.
    CrossrefPubMedSearch in Google Scholar
  • 128 Loeb C, Meyer JS. Vascular dementia: still a debatable entity?. J Neurol Sei 1996; 143: 31-40.
    CrossrefPubMedSearch in Google Scholar
  • 129 Logigian EL, Johnson KA, Kijewski MF. et al. Reversible cerebral hypoperfusion in Lyme encephalopathy. Neurology 1997; 49: 1661-70.
    CrossrefPubMedSearch in Google Scholar
  • 130 Lopez OL, Litvan I, Catt KE, Stowe R, Klunk W, Kaufer DI, Becker JT, DeKosky ST. Accuracy of four clinical diagnostic criteria for the diagnosis os neurodegenerative dementias. Neurology 1999; 53: 1292-9.
    CrossrefPubMedSearch in Google Scholar
  • 131 Maini CL, Pigorini F, Pau FM. et al. Cortical cerebral blood flow in HIV-1-related dementia complex. Nucl Med Commun 1990; 11: 639-48.
    CrossrefPubMedSearch in Google Scholar
  • 132 Malison RT, Price LH, Berman R. et al. Reduced brain serotonin transporter availability in major depression as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl) tropane and single photon emission computed tomography. Biol Psychiatry 1998; 44: 1090-8.
    CrossrefPubMedSearch in Google Scholar
  • 133 Markus HS, Duchen LW, Parkin EM. et al. Creutzfeldt-Jakob disease in recipients of human growth hormone in the United Kingdom: A clinical and radiographic study. Q J Med 1992; 82: 43-51.
    Search in Google Scholar
  • 134 Martinot JL, Hardy P, FÈline A. et al. Left prefrontal glucose hypometabolism in the depressed state: A confirmation. Am J Psychiatry 1990; 147: 1313-7.
    CrossrefPubMedSearch in Google Scholar
  • 135 Masdeu JC, Yudd A, Van Heertum RL. et al. Single-photon emission computed tomography in human immunodeficiency virus encephalopathy: A preliminary report. J Nucl Med 1991; 32: 1471-5.
    PubMedSearch in Google Scholar
  • 136 Masdeu JC, van Heertum RL, Kleiman A, Anselmi G, Kissane K, Horng J, Yudd A, Luck D, Grundman M. Early single-photon emission computed tomography in mild head trauma. A controlled study. J Neuroimaging 1994; 4: 177-81.
    CrossrefPubMedSearch in Google Scholar
  • 137 Masdeu JC, Van Heertum RL, Abdel-Dayem H. Viral infections of the brain. J Neuroimaging. 1995 5 [Suppl. 1]: S40-S44.
    PubMedSearch in Google Scholar
  • 138 Matochik JA, Molchan SE, Zametkin AJ, Warden DL, Sunderland T, Cohen RM. Regional cerebral glucose metabolism in autopsyconfirmed Creutzfeldt-Jakob disease. Acta Neurol Scand 1995; 91: 153-7.
    PubMedSearch in Google Scholar
  • 139 Matthew E, Vasile RG, Sachs G, Anderson J, Lafer B, Hill T. Regional cerebral blood flow changes after light therapy in seasonal affective disorder. Nucl Med Commun 1996; 17: 475-9.
    CrossrefPubMedSearch in Google Scholar
  • 140 Mattman A, Feldman H, Forster B, Li D, Szasz I, Beattie BL, Schulzer M. Regional HMPAO SPECT and CT measurements in the diagnosis of Alzheimer’s disease. Can J Neurol Sei 1997; 24: 22-8.
    Search in Google Scholar
  • 141 Mayberg HS, Starkstein SE, Sadzot B. et al. Selective hypometabolism in the inferior frontal lobe in depressed patients with Parkinson’s disease. Ann Neurol 1990; 28: 57-64.
    CrossrefPubMedSearch in Google Scholar
  • 142 Mayberg HS, Starkstein SE, Peyser CE, Brandt J, Dannais RF, Folstein SE. Paralimbic frontal lobe hypometabolism in depression associated with Huntington’s disease. Neurology 1992; 42: 1791-7.
    CrossrefPubMedSearch in Google Scholar
  • 143 Mayberg HS, Lewis PJ, Regenold W, Wagner Jr. HN. Paralimbic hypoperfusion in unipolar depression. J Nucl Med 1994; 35: 929-34.
    PubMedSearch in Google Scholar
  • 144 Mayberg HS, Brannan SK, Mahurin RK. et al. Cingulate function in depression: A potential predictor of treatment response. Neuroreport 1997; 8: 1057-61.
    CrossrefPubMedSearch in Google Scholar
  • 145 McCune WJ, MacGuire A, Aisen A, Gebarski S. Identification of brain lesions in neuropsychiatrie systemic lupus erythematosus by magnetic resonance scanning. Arthritis Rheum 1988; 31: 159-166.
    CrossrefPubMedSearch in Google Scholar
  • 146 McDonald K, Hutchinson M, Bresnihan B. The frequent occurrence of neurological disease in patients with late-onset lupus erythematosus. Br J Rheumatol 1984; 23: 186-189.
    CrossrefPubMedSearch in Google Scholar
  • 147 McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimers’s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease Neurology. 1984; 34: 939-44.
    PubMedSearch in Google Scholar
  • 148 Meitzer CC, Smith G, DeKosky ST. et al. Serotonin in aging, late-life depression, and Alzheimer’s disease: The emerging role of functional imaging. Neuropsychopharmacology 1998; 18: 407-30.
    CrossrefPubMedSearch in Google Scholar
  • 149 Menzel C, Reinhold U, Grünwald F, v. Smekal A, Uerlich M, Rieker O, Hotze AL, Biersack HJ. Cerebral blood flow in Sneddon syndrome. J Nucl Med 1994; 35: 461-4.
    PubMedSearch in Google Scholar
  • 150 Messa C, Perani D, Lucignani G, Zenorini A, Zito F, Rizzo G, Grassi F, Del Sole A, Franche-schi M, Gilardi MC. High-resolution technetium-99m-HMPAO SPECT in patients with probable Alzheimer’s disease: comparison with fluorine-18-FDG PET. J Nucl Med 1994; 35: 210-6.
    PubMedSearch in Google Scholar
  • 151 Meusser S, Rubbert A, Manger B, Bock E, Platsch G, Feistel H. et al. 99m-Tc-HMPAOSPECT in diagnosis of early cerebral vasculitis. Rheumatol Int 1996; 16: 37-42.
    CrossrefPubMedSearch in Google Scholar
  • 152 Meyer JH, Kapur S, Houle S. et al. Prefrontal cortex 5-HT2 receptors in depression: An [18F]setoperone PET imaging study. Am J Psychiatry 1999; 156: 1029-34.
    PubMedSearch in Google Scholar
  • 153 Meyer MA, Hübner KF, Raja S, Hunter K, Paulsen WA. Sequential positron emission tomographic evaluations of brain metabolism in acute herpes. J Neuroimaging 1994; 4: 104-5.
    CrossrefPubMedSearch in Google Scholar
  • 154 Mielke R, Herholz K, Grond M, Kessler I, Heiss WD. Differences of regional cerebral glucose metabolism between presenile and senile dementia of Alzheimer type. Neurobiol aging 1992; 13: 93-8.
    CrossrefPubMedSearch in Google Scholar
  • 155 Mielke R, Pietrzyk U, Jacobs A, Fink GR, Ichimiya A, Kessler J, Herholz K, Heiss WD. HMPAO SPET and FDG PET in Alzheimer’s disease and vascular dementia: comparison of perfusion and metabolic pattern. Eur J Nucl Med 1994; 21: 1052-60.
    PubMedSearch in Google Scholar
  • 156 Miller BL, Ikonte C, Ponton M, Levy M, Boone K, Darby A, Berman N, Mena I, Cummings JL. A study of the Lund-Manchester research criteria for frontotemporal dementia. Clinical and single-photon emission CT correlations. Neurology 1997; 48: 937-42.
    CrossrefPubMedSearch in Google Scholar
  • 157 Miller DH, Ormerod IEC, Gibson A, duBoulay EPGH, Rudge P, McDonald W. MR brain scanning in patients with vasculitis: Differentiation from multiple sclerosis. Neuroradiology 1987; 29: 226-31.
    CrossrefPubMedSearch in Google Scholar
  • 158 Möller H-J, Laux G, Deister A. Psychiatrie. Stuttgart: Hippokrates Verlag; 1996
    Search in Google Scholar
  • 159 Moore H, West AR, Grace AA. 1999; The regulation of forebrain dopamine transmission: relevance to the pathophysiology and psychopathology of schizophrenia. Biol Psychiatry 46: 40-55.
    CrossrefPubMedSearch in Google Scholar
  • 160 Mori E, Ishii K, Hashimoto M, Imamura T, Hirono N, Kitagaki H. Role of functional brain imaging in the evaluation of vascular dementia. Alzheimer Dis Assoc Disord 1999; 13 (Suppl. 03) S91-101.
    PubMedSearch in Google Scholar
  • 161 Na DL, Suh CK, Choi SH. et al. Diffusionweighted magnetic resonance imaging in probable Creutzfeldt-Jakob disease: A clincalanatomic correlation. Arch Neurology 1999; 56: 951-57.
    CrossrefPubMedSearch in Google Scholar
  • 162 Nagamachi S, Nichikawa T, Ono S, Kawasaki K, Eguchi G, Hoshi H, Jinnouchi S, Ohnishi T, Futami S, Watanabe K. A comparative study of I-123-IMP SPET and CT in the investigation of chronic-stage head trauma patients. Nucl Med Commun 1995; 16: 17-25.
    CrossrefPubMedSearch in Google Scholar
  • 163 Nagel JS, Ichise M, Holman BL. he scintigraphic evaluation of Huntington’s disease and other movement disorders using single photon emission computed tomography perfusion brain scans. Semin Nucl Medl 1991; 21: 11-23.
    Search in Google Scholar
  • 164 Nedd K, Sfakianakis G, Ganz W, Uricchio B, Vernberg D, Villanueva P, Jabir AM, Bartlett J, Keena J. Tc-99m-HMPAO SPECT of the brain in mild to moderate traumatic brain injury patients: compared with CT-a prospective study. Brain Inj 1993; 7: 469-79.
    CrossrefPubMedSearch in Google Scholar
  • 165 Nisijima K, Matoba M, Ishiguro T. Single photon emission computed tomography with 123I-IMP in three cases of the neuroleptic malignant syndrome. Neuroradiol 1994; 36: 281-4.
    CrossrefPubMedSearch in Google Scholar
  • 166 Nordstrom AL, Farde L, Eriksson L, Halldin C. No elevated D2 dopamine receptors in neuroleptic-naive schizophrenic patients revealed by positron emission tomography and [11 C]Nmethylspiperone. Psychiatry Res 1995; 61: 67-83.
    CrossrefPubMedSearch in Google Scholar
  • 167 Nossent JC, Hovestadt A, Schönfeld DHW, Swaak AJG. Single-photon-emission computed tomography of the brain in the evaluation of cerebral lupus. Arthritis Rheum 1991; 34: 1397-402.
    PubMedSearch in Google Scholar
  • 168 Nyberg S, Farde L, Halldin C, Dahl ML, Bertilsson L. D2 dopamine receptor occu-pancy during low-dose treatment with haloperidol decanoate. Am J Psychiatry 1995; 152: 173-8.
    CrossrefPubMedSearch in Google Scholar
  • 169 Nyberg S, Nilsson U, Okubo Y, Halldin C, Farde L. Implication of brain imaging for the management of schizophrenia. Int Clin Psychopharmacol. 1998 13 [Suppl. 3]: S15-S20.
    PubMedSearch in Google Scholar
  • 170 Ogawa T, Inugami A, Fujita H. et al. Serial positron emission tomography with fludeoxyglucose F 18 in Creutzfeldt-Jakob disease. Am J Neuroradiol 1995; 16 (Suppl. 04) 978-81.
    PubMedSearch in Google Scholar
  • 171 Ohyama M, Senda M, Ishiwata K, Kitamura S, Mishina M, Ishii K, Toyama H, Oda K. Katayama Y.Preserved benzodiazepine receptors in Alzheimer’s disease measured with C-ll flumazenil PET and 1-123 iomazenil SPECT in comparison with CBF. Ann Nucl Med 1999; 13: 309-15.
    CrossrefPubMedSearch in Google Scholar
  • 172 Okubo Y, Suhara T, Suzuki K. et al. Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET. Nature 1997; 385: 634-6.
    CrossrefPubMedSearch in Google Scholar
  • 173 O’Mahony D, Coffey J, Murphy J, O’Hare N, Hamilton D, Freyne P, Walsh JB, Coackley D. The discriminant value of semiquantitative SPECT data in mild Alzheimer’s disease. J Nucl Med 1994; 35: 1450-5.
    PubMedSearch in Google Scholar
  • 174 Otte A, Weiner SM, Peter HH. et al. Brain glucose utilization in systemic lupus erythematosus with neuropsychiatrie symptoms: A controlled positron emission tomography study. Eur J Nucl Med 1997; 24: 787-91.
    PubMedSearch in Google Scholar
  • 175 Parellada E, Catafau AM, Bernardo M, Lomena F, Catarineu S, Gonzalez-Monclüs E. The resting and activation issue of hypofrontality: A single photon emission computed tomography study in neuroleptic-naive and neuroleptic-free schizophrenic female patients. Biol Psychiatry 1998; 44: 787-790.
    CrossrefPubMedSearch in Google Scholar
  • 176 Paulus W, Bancher C, Jellinger K. Die Neuropathologie der Demenzen. Dtsch Ärzteblatt 1995; 92: 2340-5.
    Search in Google Scholar
  • 177 Pickut BA, Saerens J, Borggreve F, Goeman J, Vandevivere J, Vervaet A, Dierckx R, de Deyn PP. Discriminative use of SPECT in frontal lobe-type dementia versus (senile) dementia of the Alzheimer’s type. J Nucl Med 1997; 38: 929-34.
    PubMedSearch in Google Scholar
  • 178 Pilowsky LS, O’Connell P, Davies N. et al. In vivo effects on striatal dopamine D2 receptor binding by the novel atypical antipsychotic drug sertindole – a 1231 IBZM single photon emission tomography (SPET) study. Psychopharmacology Berl 1997; 130: 152-8.
    CrossrefPubMedSearch in Google Scholar
  • 179 Reid RH, Gulenchyn KY, Ballinger JR, Venturey RA. Cerebral perfusion imaging with technetium-99m HMPAO following cerebral trauma: initial experience. Clin Nucl Med 1990; 15: 383-8.
    CrossrefPubMedSearch in Google Scholar
  • 180 Reiff A, Miller J, Shaham B, Bernstein B, Szer IS. Childhood central nervous system lupus; longitudinal assessment using single photon emission computed tomography. J Rheumatol 1997; 24: 2461-5.
    Search in Google Scholar
  • 181 Reiman EM, Caselli RJ, Yun LS, Chen K, Bandy D, Minoshima S, Thibodeau SN, Osborne D. Preclinical evidence of Alzheimer’s disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med 1996; 334: 752-8.
    CrossrefPubMedSearch in Google Scholar
  • 182 Rieck H, Adelwöhrer C, Lungenschmid K, Deisenhammer E. Discordance of technetium-99m-HMPAO and technetium-99m-ECD SPECT in herpes simplex encephalitis. J Nucl Med 1998; 39: 1508-10.
    PubMedSearch in Google Scholar
  • 183 Rosci MA, Pigorini F, Bernabei A. et al. Methods for detecting early signs of AIDS dementia complex in asymptomatic HIV-1-infected subjects. AIDS 1992; 6: 1309-16.
    CrossrefPubMedSearch in Google Scholar
  • 184 Rosenberg MR, Green M. Neuroleptic malignant syndrome: Review of response to therapy. Arch Intern Med 1989; 149: 1927-31.
    CrossrefPubMedSearch in Google Scholar
  • 185 Rubbert A, Marienhagen J, Pirner K. et al. Single-photon-emission computed tomography analysis of cerebral blood flow in the evaluation of central nervous system involvement in patients with systemic lupus erythematosus. Arthritis Rheum 1993; 36: 1253-62.
    CrossrefPubMedSearch in Google Scholar
  • 186 Russell JM, Early TS, Patterson JC, Martin JL, Villanueva-Meyer J, McGee MD. Temporal lobe perfusion asymmetries in schizophrenia. J Nucl Med 1997; 38: 607-12.
    PubMedSearch in Google Scholar
  • 187 Russo R, Gilday D, Laxer RM, Eddy A, Silverman ED. Single photon emission computed tomography scanning in childhood systemic lupus erythematosus. J Rheumatol 1998; 25: 576-82.
    Search in Google Scholar
  • 188 Sabri O, Erkwoh R, Schreckenberger M. et al. Regional cerebral blood flow and negative/positive symptoms in 24 drug-naive schizophrenics. J Nucl Med 1997; 38: 181-8.
    PubMedSearch in Google Scholar
  • 189 Sabri O, Erkwoh R, Schreckenberger M, Owega A, Saß H, Buell U. Correlation of positive symptoms exclusively to hyperperfusion or hypoperfusion of cerebral cortex in nevertreated schizophrenics. Lancet 1997; 349: 1735-9.
    CrossrefPubMedSearch in Google Scholar
  • 190 Sabri O, Ringelstein EB, Hellwig D, Schneider R, Schreckenberger M, Kaiser HJ, Mull M, Buell U. Neuropsychological impairment correlates with hypoperfusion and hypometabolism but not with severity of white matter lesions on MRI in patients with cerebral microangiopathy. Stroke 1999; 30: 556-66.
    CrossrefPubMedSearch in Google Scholar
  • 191 Sacktor N, Prohovnik I, Van Heertum RL. et al. Cerebral single-photon emission computed tomography abnormalities in human immunodeficiency virus type 1-infected gay men without cognitive impairment. Arch Neurology 1995; 52: 607-11.
    CrossrefPubMedSearch in Google Scholar
  • 192 Sacktor N, Van Heertum RL, Dooneief G. et al. A comparison of cerebral SPECT abnormalities in HIV-positive homosexual men with and without cognitive impairment. Arch Neurology 1995; 52: 1170-3.
    CrossrefPubMedSearch in Google Scholar
  • 193 Sarikaya A, Karasin E, Cermik TF, Abay E, Berkarda S. Evaluation of dysthymic disorder with technetium-99m hexamethylpropylene amine oxime brain single-photon emission tomography. Eur J Nucl Med 1999; 26: 260-264.
    CrossrefPubMedSearch in Google Scholar
  • 194 Scheltens P. Early diagnosis of dementia: neuroimaging. J Neurol 1999; 246: 16-20.
    PubMedSearch in Google Scholar
  • 195 Scherer J, Tatsch K, Schwarz J, Oertel WH, Konjarczyk M, Albus M. D2-dopamine receptor occupancy differs between patients with and without extrapyramidal side effects. Acta Psychiatr Scand 1994; 90: 266-8.
    CrossrefPubMedSearch in Google Scholar
  • 196 Scherer J, Tatsch K, Schwarz J, Oertel WH, Kirsch MC, Albus M. Striatal D2-dopamine receptor occupancy during treatment with typical and atypical neuroleptics. Biol Psychiatry 1994; 36: 627-9.
    CrossrefPubMedSearch in Google Scholar
  • 197 Schmidbauer M, Podreka I, Wimberger D. et al. SPECT and MR imaging in herpes simplex encephalitis. J Comp Assist Tomogr 1991; 15: 811-5.
    CrossrefPubMedSearch in Google Scholar
  • 198 Schröder J, Bubeck B, Demisch S, Sauer H. Benzodiazepine receptor distribution and diazepam binding in schizophrenia: An exploratory study. Psychiatry Res 1997; 68: 125-31.
    CrossrefPubMedSearch in Google Scholar
  • 199 Schwartz RB, Komaroff AL, Garada BM. et al. SPECT imaging of the brain: Comparison of findings in patients with chronic fatigue syndrome. AIDS dementia complex, and major unipolar depression. Am J Roentgenol 1994; 162: 943-51.
    CrossrefPubMedSearch in Google Scholar
  • 200 Sedvall G. The current status of PET scanning with respect to schizophrenia. Neuropsychopharmacology 1992; 7: 41-54.
    PubMedSearch in Google Scholar
  • 201 Seeman P. Elevated D2 in schizophrenia: role of endogenous dopamine and cerebellum. Commentary on ‘The current status of PET scanning with respect to schizophrenia’. Neuropsychopharmacology 1992; 7: 55-57.
    PubMedSearch in Google Scholar
  • 202 Sheppard G, Manchanda R, Gruzelier J. et al. Oxygen-15 positron emission tomographic scanning in predominantly never treated acute schizophrenic patients. Lancet 1983; 2: 1448-52.
    PubMedSearch in Google Scholar
  • 203 Stoppe G, Wildhagen K, Seidel JW, Meyer G-J, Schober O, Heintz P, Künkel H, Deicher H, Hundeshagen H. Positron emission tomography in neuropsychiatrie lupus erythematosus. Neurol 1990; 40: 304-8.
    CrossrefPubMedSearch in Google Scholar
  • 204 Szer IS, Miller JH, Rawlings D, Shaham B, Bernstein B. Cerebral perfusion abnormalities in children with central nervous manifestations of lupus detected by single photon emission computed tomography. J Rheumatol 1993; 20: 2143-8.
    Search in Google Scholar
  • 205 Szeto ER, Freund J, Brew BJ, Loder A. Griffiths. Cerebral perfusion scanning in treating AIDS dementia: A pilot study. J Nucl Med 1998; 39: 298-302.
    PubMedSearch in Google Scholar
  • 206 Talbot PR, Lloyd JJ, Snowden JS, Neary D, Testa HJ. A clinical role for 99mTc-HMPAO SPECT in the investigation of dementia?. J Neurol Neurosurg Psychiatry 1998; 64: 306-13.
    CrossrefPubMedSearch in Google Scholar
  • 207 Tanaka M, Uesugi M, Igeta Y, Kondo S, Sun X, Hirai S. Luxury perfusion phenomenon in acute herpes simplex virus encephalitis. Ann Nucl Med 1995; 9: 43-5.
    CrossrefPubMedSearch in Google Scholar
  • 208 Tauscher J, Kufferle B, Asenbaum S. et al. In vivo 1231IBZM SPECT imaging of striatal dopamine-2 receptor occupancy in schizophrenic patients treated with olanzapine in comparison to clozapine and haloperidol. Psychopharmacology Berl 1999; 141: 175-81.
    CrossrefPubMedSearch in Google Scholar
  • 209 Tatsch K, Schielke E, Bauer WM, Markl A, Einhäupl KM, Kirsch CM. Functional and morphological findings in early and advanced stages of HIV infection: A comparison of 99mTc-HMPAO SPECT with CT and MRI studies. Nuklearmedizin 1990; 29: 252-8.
    Thieme ConnectPubMedSearch in Google Scholar
  • 210 The Huntington’s Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. Cell 1993; 72: 971-83.
    CrossrefPubMedSearch in Google Scholar
  • 211 Tohyama Y, Sako K, Daita G, Yonemasu Y, Shuke N, Aburano T. Dissociation of 99mTc-ECD and 99mTc-HMPAO distributions in herpes simplex encephalitis. Child’s Nervous System 1997; 13: 352-5.
    PubMedSearch in Google Scholar
  • 212 Tozzi V, Narciso P, Galgani S. et al. Effects of zidovudine in 30 patients with mild to endstage AIDS dementia complex. AIDS 1993; 7: 683-92.
    CrossrefPubMedSearch in Google Scholar
  • 213 Travis MJ, Busatto GF, Pilowsky LS. et al. 5-HT2A receptor blockade in patients with schizophrenia treated with risperidone or clozapine. A SPET study using the novel 5-HT2A ligand 123I-5-I-R-91150. Br J Psychiatry 1998; 173: 236-41.
    CrossrefPubMedSearch in Google Scholar
  • 214 Trichard C, Paillère-Martinot ML, Attar-Levy D, Blin J, Féline A, Martinot JL. No serotonin 5-HT2A receptor density abnormality in the cortex of schizophrenic patients studied with PET. Schizoph Res 1998; 31: 13-7.
    CrossrefPubMedSearch in Google Scholar
  • 215 Tune LE, Wong DF, Pearlson G. et al. Dopamine D2 receptor density estimates in schizophrenia: A positron emission tomography study with llC-N-methvlspiperone. Psvchiatrv Res 1993; 49: 219-37.
    Search in Google Scholar
  • 216 Tutus A, Simsek A, Sofuoglu S. et al. Changes in regional cerebral blood flow demonstrated by single photon emission computed tomography in depressive disorders: Comparison of unipolar vs. bipolar subtypes. Psychiatry Res 1998; 83: 169-77.
    CrossrefPubMedSearch in Google Scholar
  • 217 Varma AR, Talbot P, Snowden J, Lloyd JL, Testa H, Neary D. A Tc-99m H M PAO singlephoton emission computed tomography study on Lewy body disease. J Neurol 1997; 244: 349-59.
    CrossrefPubMedSearch in Google Scholar
  • 218 Varrone A, Soricelli A, Postiglione A, Salvatore M. Comparison between cortical distribution of 1-123 iomazenil andTc-99m HMPAO in patients with Alzheimer’s disease using SPECT. Clin Nucl Med 1999; 24: 660-5.
    CrossrefPubMedSearch in Google Scholar
  • 219 Vasile RG, Sachs G, Anderson JL, Lafer B, Matthews E, Hill T. Changes in regional cerebral blood flow following light treatment for seasonal affective disorder: Responders versus nonresponders. Biol Psychiatry 1997; 42: 1000-5.
    CrossrefPubMedSearch in Google Scholar
  • 220 Villemagne VL, Phillips RL, Liu X. et al. Peptide T and glucose metabolism in AIDS dementia complex. J Nucl Med 1996; 37: 1177-80.
    PubMedSearch in Google Scholar
  • 221 Volkow ND, Brodie JD, Wolf AP, Angrist B, Russel J, Cancro R. Brain metabolism in patients with schizophrenia before and after acute neuroleptic administration. J Neurol Neurosurg Psychiatry 1986; 49: 1199-202.
    CrossrefPubMedSearch in Google Scholar
  • 222 Waldemar G, Hogh P, Paulson OB. Functional brain imaging with single photon-emission computed tomography in the diagnosis of Alzheimer’s disease. Int Psychogeriatr 1997; 9 (Suppl. 01) 223-7.
    PubMedSearch in Google Scholar
  • 223 Watanabe N, Seto H, Shimizu M. et al. Brain SPECT of Creutzfeldt-Jakob disease. Clin Nucl Med 1996; 21: 236-41.
    CrossrefPubMedSearch in Google Scholar
  • 224 Weinberger DR, Gibson R, Coppola R, Jones DW, Molchan S, Sunderland T, Berman KF. Reba RC.The distribution of cerebral muscarinic acetylcholine receptors in vivo in patients with dementia. A controlled study with 123IQNB and single photon emission computed tomography. Arch Neurol 1991; 48: 169-76.
    CrossrefPubMedSearch in Google Scholar
  • 225 Weinstein HC, Hijdra A, Van Royen EA, Derix MM, Walstra G, Jonker C. SPECT in earlyand late-onset Alzheimer’s disease. Ann-N-YAcad-Sci 1991; 640: 72-3.
    CrossrefPubMedSearch in Google Scholar
  • 226 Weis S, Haug H, Budka H. Vascular changes in the cerebral cortex in HIV-1 infection: I. A morphometric investigation by light and electron microscopy Clin Neuropathol 1996; 15: 361-66.
    PubMedSearch in Google Scholar
  • 227 Wiesel FA, Wik G, Sjögren I, Blomqvist G, Greitz T, Stone-Elander S. Regional brain glucose metabolism in durg free schizophrenic patients and clinical correlates. Acta Psychiatr Scand 1987; 76: 628-41.
    CrossrefPubMedSearch in Google Scholar
  • 228 Wiesel FA, Farde L, Nordstrom AL, Sedvall G. Central D1 – and D2-dopamine receptor occupancy curing antipsychotic drug treatment. Prog Neuropsychopharmacol Biol Psychiatry 1990; 14: 759-67.
    CrossrefPubMedSearch in Google Scholar
  • 229 Wong DF, Wagner Jr. HN, Tune LE. et al. Positron emission tomography reveals D2 dopamine receptors in drug-naive schizophrenics. Science 1986; 234: 1558-63. [Erratum published in Science 1987; 235: 623.
    CrossrefPubMedSearch in Google Scholar
  • 230 Wong WF, Pearlson GD, Tune LE. et al. Quantification of neuroreceptors in the living human brain. IV. Effect of aging and elevations of D2-like receptors in schizophrenia and bipolar illness. J Cereb Blood Flow Metab 1997; 17: 331-42.
    CrossrefPubMedSearch in Google Scholar