Subscribe to RSS
DOI: 10.1055/s-0038-1629547
Stellenwert der 99mTc-M DP-Skelettszintigraphie beim Neuroblastom
Ist eine Neubewertung nötig?[*] The Value of 99mTc-MDP Bone Scintigraphy in Patients with NeuroblastomaPublication History
Eingegangen:
23 August 1990
Publication Date:
04 February 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00034924/199101/lookinside/thumbnails/10-1055-s-0038-1629547_de-1.jpg)
The present study compares the reliability of MIBG and MDP bone scans in detecting bone metastases of neuroblastoma. Out of 57 patients, 23 had both 99mTc-MDP and 123I/131I-MIBG scans within a 2-week period. In 10 patients at primary diagnosis there was an underestimation of skeletal involvement by MIBG in 1/5, in 13 patients at follow-up in 3/9; 99mTc-MDP scans were able to visualize skeletal involvement in all those cases. There was only one false positive MDP scan. These results suggest that MIBG alone may fail to visualize skeletal involvement of neuroblastoma and should therefore be complemented by additional 99mTc-MDP scintigraphy
Zusammenfassung
Die vorliegende Studie vergleicht die MIBG- und die MDP-Szintigraphie hinsichtlich ihrer Zuverlässigkeit in der Darstellung der Skelettbeteiligung beim Neuroblastom. Von 57 Patienten wurden 23 mit beiden Verfahren in einem Intervall von längstens 2 Wochen untersucht. In der Erstdiagnostik-Gruppe wurden mit der MIBG-Szintigraphie in 1/5, in der Follow-up-Gruppe bei 3/9 Patienten eine Knochenmetastasierung nicht dargestellt, die sich in der MDP-Szintigraphie in allen Fällen eindeutig zeigte. Die MDP-Szintigraphie lieferte nur ein einziges falsch-positives Ergebnis. Diese Ergebnisse deuten darauf hin, daß bei alleiniger MIBG-Szintigraphie im Skelettbereich u. U. eine diagnostische Lücke entsteht, die durch eine ergänzende MDP-Szintigraphie geschlossen werden kann. Beide Verfahren sollten deshalb parallel eingesetzt werden.
* Herrn Prof. Dr. med. K. zum Winkel zum 70. Geburtstag.
-
LITERATUR
- 1 Baker M, Siddiqui AR, Provisor A, Cohen MD. Radiographie and scintigraphic skeletal imaging in patients with neuroblastoma. J Nucl Med 1983; 24: 647-69.
- 2 Bouvier JF, Philip T, Chauvot P. et al. Pitfalls and solutions in neuroblastoma diagnosis using radioiodine MIBG: our experience in about 50 cases. Prog Clin Biol Res 1988; 271: 707-20.
- 3 Brodeur GM, Seeger RC. et al. International neuroblastoma staging system (INSS) and treatment response criteria. In: Advances in Neuroblastoma Research 2: Proc 4th Symp Adv Neuroblastoma Res. New York: Alan Liss; 1988: 509-24.
- 4 Brown ML. Significance of the solitary lesion in pediatric bone scanning. J Nucl Med 1983; 24: 114-5.
- 5 Daubenton JD, Fisher RM, Karabus CD, Mann MD. The relationship between prognosis and scintigraphic evidence of bone metastases in neuroblastoma. Cancer 1987; 59: 1586-9.
- 6 Evans AE. Natural history of neuroblastoma. In: Evans AE. ed. Advances in neuroblastoma research. New York: Raven Press; 1980: 3-12.
- 7 Fawcett HD, McDoughall IR. Bone scan in extraskeletal neuroblastoma with hot primary and cold skeletal metastases. Clin Nucl Med 1980; 05: 49-50.
- 8 Feine U. Scintigraphic imaging of neuroblastoma with I-131 MIBG and first attempts at its therapeutic use. Nucl-Med. Suppl 21, Stuttgart - New York: Schattauer; 1984
- 9 Feine U, Müller-Schauenburg W, Treuner J, Klingebiel TH, Keller KD. Radiojodmarkiertes MIBG (meta-Jodbenzylguanidin) in der Diagnostik und Therapie von Neuroblastomen. Der Nuklearmediziner 1987; 10: 293-306.
- 10 Geatti O, Shapiro B, Sisson JC. et al. Iodine- 131 metaiodobenzylguanidine scintigraphy for the location of neuroblastoma. Preliminary experience in ten cases. J Nucl Med 1985; 26: 736-42.
- 11 Gilday DL, Greenberg M. The controversy about the nuclear medicine investigation of neuroblastoma. Editorial. J Nucl Med 1990; 31: 135.
- 12 Gordon I, Peters AM, Gutman A. et al. Skeletal assessment in neuroblastoma - the pitfalls of iodine-123-MIBG scans. J Nucl Med 1990; 31: 129-134.
- 13 Heyman S, Evans EA, d’Angio GJ. I-131- meta-iodobenzylguanidine: diagnostic use in neuroblastoma patients in relapse. Med Pediatr Oncol 1988; 16: 337-40.
- 14 Hoefnagel CA, Voute PA, de Kraker J, Marcuse MR. Radionuclide detection and therapy of neural crest tumors using 131-1- metaiodobenzyl-guanidine. J Nucl Med 1987; 28: 308-14.
- 15 Jaffe N. Neuroblastoma: review of the literature and an examination of factors contributing to its enigmatic character. Cancer Treat Rev 1976; 03: 61-82.
- 16 Kaufmann RA, Thrall JH, Keyes JW. et al. False negative bone scans in neuroblastoma metastases to the ends of long bones. Am J Roentg 1978; 130: 131-5.
- 17 Kimmig B, Brandeis WE, Eisenhut M. Scintigraphy of neuroblastoma with 1-131- MIBG. J Nucl Med 1984; 25: 773-5.
- 18 Lynn MD, Braunstein EM, Wahl RL. et al. Bone metastases in pheochromocytoma: comparative studies of efficacy of imaging. Radiology 1986; 160: 701-6.
- 19 Moyes JSE, Babich JW, Carter R. et al. Quantitative study of radioiodinated metaiodobenzylguanidine uptake in children with neuroblastoma. J Nucl Med 1989; 30: 474-80.
- 20 Munker T. 131I-meta-iodobenzylguanidine scintigraphy of neuroblastomas. Sem Nucl Med 1985; 15: 154-60.
- 21 Pizzo PA, Horowitz ME, Poplack DG, Hays DM, Kun LE. Solid tumors in childhood. In: De Vita VT, Hellman S, Rosenberg SA. eds. Cancer principles and practice of oncology. Philadelphia: Lippincott; 1989: 1612-70.
- 22 Prasad KN, Mandal B, Kumar S. Demonstration of cholinergic cells in human neuroblastoma and ganglioneuroma. J Pediatr 1973; 82: 677-779.
- 23 Schwabe D, Sahm S, Gerein V. et al. 131-metaiodo-benzylguanidine therapy of neuroblastoma in childhood. One year of therapeutic experience. Eur J Pediatr 1987; 146: 246-50.
- 24 Shaw DG. Oncology and hematology. In: Gordon I. ed. Diagnostic imaging in pediatrics. London: Chapman and Hall; 1987: 112-4.
- 25 Shulkin BL, Shen SW, Sisson JC, Shapiro B. Iodine-131-MIBG scintigraphy of the extremities in metastatic pheochromocytoma and neuroblastoma. J Nucl Med 1987; 28: 315-8.
- 26 Tobes MC, Jaques S, Wieland DM. Effect of uptake one inhibitor on the uptake of norepinephrine and metaiodobenzylguanidine. J Nucl Med 1985; 26: 897-907.
- 27 Treuner J, Feine U, Niethammer D. et al. Scintigraphic imaging of neuroblastoma with (131) iodobenzylguanidine. Lancet 1984; 04: 333-4.
- 28 Troncone L, Rufini V, Montemaggi P. et al. The diagnostic and therapeutic utility of radioiodinated metaiodobenzylguanidine (MIBG). Eur J Nucl Med 1990; 16: 325-35.
- 29 Weingard T, Heymann S, Alawi A. Cold lesions on bone scan in pediatric neoplasm. Clin Nucl Med 1984; 09: 125-30.
- 30 West GJ, Uki J, Herschman HR, Seeger RC. Adrenergic, cholinergic, and inactive human neuroblastoma cell lines with action potential Na+-ionophore. Cancer Res 1977; 37: 1372-6.
- 31 Young JL, Ries LG, Silverberg E, Horm JW, Miller RW. Cancer incidence, survival and mortality for children younger than age 15 years. Cancer 1986; 58: 598-602.