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Kinder- und Jugendmedizin 2013; 13(05): 354-361
DOI: 10.1055/s-0038-1629358
Übersichtsartikel
Schattauer GmbH

Disruptive Mood Dysregulation Disorder

Neues Störungsbild im DSM-5Disruptive mood dysregulation disorder as new disorder in the DSM-5
P.L. Plener
1   Klinik für Kinder- und Jugendpsychiatrie und Psychotherapie, Universitätsklinikum Ulm
,
A. Witt
1   Klinik für Kinder- und Jugendpsychiatrie und Psychotherapie, Universitätsklinikum Ulm
,
J. Straub
1   Klinik für Kinder- und Jugendpsychiatrie und Psychotherapie, Universitätsklinikum Ulm
,
J.M. Fegert
1   Klinik für Kinder- und Jugendpsychiatrie und Psychotherapie, Universitätsklinikum Ulm
› Author Affiliations
Further Information

Publication History

Eingegangen am:16 July 2013

angenommen am:01 August 2013

Publication Date:
31 January 2018 (online)

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Zusammenfassung

Disruptive Mood Dysregulation Disorder (DMDD), übersetzbar als disruptive Störung der Stimmungsregulation, findet sich als neues eigenständiges Krankheitsbild im DSM-5. Im Gegensatz zu anderen disruptiven Störungsbildern wurde DMDD in den Bereich der depressiven Störungen gelegt. Der vorliegende Beitrag soll sich mit den diagnostischen Kriterien, der Prävalenz sowie den Behandlungsoptionen dieses neuen Störungsbildes, basierend auf einer selektiven Literaturübersicht auseinandersetzen. Aus Deutschland liegen keine Studien vor, die aufbauend auf den neuen diagnostischen Kriterien erstellt wurden; eine Prävalenzschätzung ist daher schwierig. Aus den USA wurden Prävalenzraten von ca. 1% aus nicht klinischen Stichproben berichtet. Die spezifischen therapeutischen Optionen zur Behandlung dieses neu geschaffenen Störungsbildes sind in ihrer Evidenz kaum überprüft. Essenziell scheinen die Trennung des Störungsbildes von bipolaren Störungen und die Beachtung von DMDD als möglicher Vorläufer einer depressiven Entwicklung.

Summary

Disruptive mood dysregulation disorder (DMDD) is described as a new disorder in the DSM-5. As opposed to other disruptive disorders, DMDD was set in the section on depressive disorders. Based on a selective review of the literature, this paper deals with the diagnostic criteria, the prevalence and the therapeutic options of this new disorder. So far, there are no studies available from Germany, which are based on the new diagnostic criteria thus complicating prevalence estimates. From the USA prevalence rates of about 1% in non-clinical samples have been reported. There is hardly any evidence supporting specific therapeutic options to treat this recently constructed disorder. It seems essential to delineate this disorder from bipolar disorder and recognize DMDD as possible predictor for the development of a depressive disorder.

Schlüsselwörter

Disruptive Mood Dysregulation Disorder - DMDD - bipolare Störung - ADHS - Gereiztheit - Depression

Keywords

Disruptive mood dysregulation disorder - DMDD - bipolar disorder - ADHD - Irritability - depression
 

  • Literatur

  • 1 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders Fifth Edition: DSM 5 Washington, DC, London: American Psychiatric Publishing; 2013: 155-160.
  • 2 Parens E, Johnston J. Controversies concerning the diagnosis and treatment of bipolar disorder in children. Child and Adolescent Psychiatry and Mental Health 2010; 4: 9
    CrossrefSearch in Google Scholar
  • 3 Holtmann M. et al. Bipolar disorder in children and adolscents in Germany: national trends in the rates of inpatients, 2000 - 2007. Bipolar Disorders 2010; 12: 155-163.
    CrossrefSearch in Google Scholar
  • 4 Leibenluft E. et al. Defining clinical phenotypes of juvenile mania. Am J Psychiatry 2003; 160: 430-437.
    CrossrefSearch in Google Scholar
  • 5 Axelson DA. et al. Concerns regarding the inclusion of temper dysregulation disorder with dysphoria in the diagnostic and statistical manual of mental disorders, Fifth Edition. J Clin Psychiatry 2011; 72: 1257-1262.
    CrossrefSearch in Google Scholar
  • 6 Holtmann M. et al. The child behavior checklist-dysregulation profile predicts substance use, suicidality, and functional impairment: a longitudinal analysis. J Child Psychol Psychiatry 2011; 52: 139-147.
    CrossrefSearch in Google Scholar
  • 7 Juksch V. et al. Severe affective and behavioural dysregulation is associated with significant psychosocial adversity and impairment. Journal of Child Psychology and Psychiatry 2011; 52: 686-695.
    CrossrefSearch in Google Scholar
  • 8 Hudziak JJ. et al. Prevalence and genetic architecture of child behavior checklist-juvenile bipolar disorder. Biol Psychiatry 2005; 58: 562-568.
    CrossrefSearch in Google Scholar
  • 9 Holtmann M, Goth K, Wöckel L, Poustka F, Bölte S. CBCL-pediatric bipolar disorder phenotype: severe ADHD or bipolar disorder?. J Neural Transm 2008; 115: 155-161.
    CrossrefSearch in Google Scholar
  • 10 Copeland WE, Angold A, Costello EJ, Egger H. Prevalence, comorbidity, and correlates of DSM-5 proposed disruptive mood dyregulation disorder. Am J Psychiatry 2013; 170: 173-179.
    CrossrefPubMedSearch in Google Scholar
  • 11 Axelson D. et al. Examining the proposed disruptive mood dysregulation disorder diagnosis in children in the longitudinal assessment of manic symptoms study. J Clin Psychiatry 2012; 73: 1342-1350.
    CrossrefSearch in Google Scholar
  • 12 Brotman MA. et al. Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation. Am J Psychiatry 2007; 164: 1238-1241.
    CrossrefSearch in Google Scholar
  • 13 Stringaris A, Cohen P, Pine DS, Leibenluft E. Adult outcomes of youth irritability: A 20-year prospective community-based study. Am J Psychiatry 2009; 166: 1048-1054.
    CrossrefSearch in Google Scholar
  • 14 Althoff RR, Verhulst F, Rettew DC, Hudziak JJ, van der Ende J. Adult outcomes of childhood dysregulation: a 14-year follow-up study. J Am Acad Child Adolesc Psychiatry 2010; 49: 1105-1116.
    Search in Google Scholar
  • 15 Ambrosini PJ, Bennett DS, Elia J. Attention deficit hyperactivity disorder characteristics: II. Clinical correlates of irritable mood. J Affect Dis 2013; 145: 70-76.
    CrossrefSearch in Google Scholar
  • 16 Waxmonsky J. et al. The efficacy and tolerability of methylphenidate and behavior modification in children with attention-deficit/hyperactivity disorder and severe mood dysregulation. J Child Adolesc Psychopharmacol 2008; 18: 573-588.
    CrossrefPubMedSearch in Google Scholar
  • 17 Adleman NE. et al. Cross-sectional and longitudinal abnormalities in brain structure in children with severe mood dysregulation or bipolar disorder. Journal of Child Psychology and Psychiatry 2012; 53: 1149-1156.
    CrossrefSearch in Google Scholar
  • 18 Thomas LA. et al. Parametric modulation of neural activity by emotion in youth with bipolar disorder, youth with severe mood dyregulation, and healthy volunteers. Arch Gen Psychiatry 2012; 69: 1257-1266.
    CrossrefSearch in Google Scholar
  • 19 Brotman MA. et al. Amygdala activation during emotion processing of neutral faces in children with severe mood dysregulation versus ADHD or bipolar disorder. Am J Psychiatry 2010; 167: 61-68.
    CrossrefSearch in Google Scholar
  • 20 Stringaris A, Zavos H, Leibenluft E, Maughan B, Eley TC. Adolescent irritability: phenotypic associations and genetic links with depressed mood. Am J Psychiatry 2012; 169: 47-54.
    CrossrefSearch in Google Scholar
  • 21 Mikita N, Stringaris A. Mood dysregulation. Eur Child Adolesc Psychiatry 2013; 22 (Suppl. 01) S11-S16.
    CrossrefSearch in Google Scholar
  • 22 Dickstein DP. et al. Randomized double-blind placebo-controlled trial of lithium in youth with severe mood dysregulation. Journal of Child and Adolescent Psychopharmacology 2009; 19: 61-73.
    CrossrefSearch in Google Scholar
  • 23 Krieger FV. et al. An open-label trial of risperidone in children and adolescents with severe mood dysregulation. Journal of Child and Adolescent Psychopharmacology 2011; 21: 237-243.
    CrossrefSearch in Google Scholar
  • 24 Leigh E, Smith P, Milavic G, Stringaris A. Mood regulation in youth: research findings and clinical approaches to irritability and short-lived episodes of mania-like symptoms. Curr Opin Psychiatry 2012; 25: 271-276.
    CrossrefSearch in Google Scholar
  • 25 Waxmonsky JG. et al. A novel group therapy for children with ADHD and severe mood dysregulation. J Atten Disord 2012. doi: 10.1177/ 1087054711433423
    Search in Google Scholar
  • 26 Bogen S, Legenbauer T, Bogen T, Gest S, Jensch T, Schneider S, Holtmann M. Morning light therapy for juvenile depression and severe mood dysregulation: study protocol for a randomized controlled trial. Trials 2013; 14: 178
    CrossrefSearch in Google Scholar