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Nervenheilkunde 2015; 34(12): 965-975
DOI: 10.1055/s-0038-1627660
Hirnstimulation
Schattauer GmbH

rTMS in der Therapie psychiatrischer Erkrankungen

Grundlagen und Methodik[*] rTMs in depressive disorderbasics and methods
P. M. Kreuzer
1   Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg am Bezirksklinikum, Regensburg
,
J. Höppner
2   Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsmedizin Rostock
,
T. Kammer
3   Klinik für Psychiatrie und Psychotherapie III, Universitätsklinikum Ulm
,
C. Schönfeldt-Lecuona
3   Klinik für Psychiatrie und Psychotherapie III, Universitätsklinikum Ulm
,
F. Padberg
4   Klinik für Psychiatrie und Psychotherapie, Klinikum der Universität München
,
M. Bajbouj
5   Klinik für Psychiatrie und Psychotherapie, Charité –Universitätsmedizin Berlin, Campus Benjamin Franklin
,
P. Zwanzger
6   kbo-Inn-Salzach-Klinikum gemeinnützige GmbH, Fachkrankenhaus für Psychiatrie, Psychotherapie, Psychosomatische Medizin, Geriatrie und Neurologie
,
C. Plewnia
7   Universitätsklinik für Psychiatrie und Psychotherapie, Universität Tübingen
,
A. Fallgatter
7   Universitätsklinik für Psychiatrie und Psychotherapie, Universität Tübingen
,
M. Landgrebe
8   kboLech-Mangfall-Klinik Agatharied, Psychiatrie – Psychotherapie – Psychosomatik
,
J. Cordes
9   LVR-Klinikum Düsseldorf, Kliniken der Heinrich-Heine-Universität Düsseldorf
,
T. Wobrock
10   Klinik für Psychiatrie und Psychotherapie, Georg-August-Universität Göttingen
11   Zentrum für Seelische Gesundheit, Kreiskliniken Darmstadt-Dieburg, Groß-Umstadt
,
A. Hasan
4   Klinik für Psychiatrie und Psychotherapie, Klinikum der Universität München
,
G. Hajak 13
12   Klinik für Psychiatrie und Psychotherapie, Sozialstiftung Bamberg, Bamberg
,
M. Schecklmann
1   Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg am Bezirksklinikum, Regensburg
,
J.-P. Lefaucheur
13   Department of Physiology, Henri Mondor Hospital, Assistance Publique – Hôpitaux de Paris, Créteil, France
14   EA 4391, Nerve Excitability and Therapeutic team, Faculty of Medicine, Paris Est Créteil University, Créteil, France
,
B. Langguth
1   Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg am Bezirksklinikum, Regensburg
› Author Affiliations
Further Information

Publication History

eingegangen am: 01 October 2015

angenommen am: 01 October 2015

Publication Date:
22 January 2018 (online)

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Zusammenfassung

Als transkranielle Magnetstimulation (TMS) wird ein Verfahren bezeichnet, bei dem ein Stimulator über eine Spule kurze elektromagnetische Pulse mit einer Flussdichte von bis zu 2 Tesla induziert, welche die Schädelkalotte mit wenig Abschwächung durchdringen und zu einer Depolarisierung neuronaler Zellverbände führen. Die Stromdichte am Stimulationsort wird von einer Vielzahl physikalischer und biologischer Parametern bestimmt: Spulengeometrie sowie -positionierung, der Abstand der Spule zum Kortex, die Pulsform, die Intensität, Frequenz und das Muster der Stimulation sowie die dreidimensionale Orientierung der stimulierten neuronalen Strukturen im Verhältnis zur Geometrie des Magnetfeldes. Bei der repetitiven transkraniellen Magnetstimulation (rTMS) werden mehrere elektromagnetische Einzelstimuli als Reizserien mit konstanter Wiederholungsrate appliziert. Mithilfe dieser repetitiven TMS können Veränderungen der neuronalen Aktivität induziert werden, die über die eigentliche Stimulationsdauer hinweg andauern. Im vorliegenden Themenheft wird die Datenlage zu etablierten und potenziellen therapeutischen Anwendungen der repetitiven transkraniellen Magnetstimulation in psychiatrischen Indikationsgebieten zusammengefasst. Eine Empfehlung mit Evidenzgrad A kann für die hochfrequente rTMS-Behandlung des linken dorsolateralen präfrontalen Kortex (DLPFC) bei depressiven Störungen ausgesprochen werden. Empfehlungen mit dem Evidenzgrad B bestehen für niederfrequente rTMS des rechten DLPFC bei der Behandlung depressiver Störungen und für hochfrequente rTMS des linken DLPFC bei depressiver Symptomatik von Patienten mit Parkinson-Syndrom. Wahrscheinlich besteht ein additiver Effekt von rTMS des DLPFC zu einer antidepressiven Pharmakotherapie. Eine Empfehlung mit dem Evidenzgrad C kann folgenden rTMS-Paradigmen zugesprochen werden: hochfrequente rTMS des linken DLPFC bei Patienten mit schizophrener Negativsymptomatik (trotz einer großen negativen Multicenterstudie), niederfrequente rTMS des linken TPC bei chronischem Tinnitus und akustischen Halluzinationen (trotz vieler Publikationen eher niedriges Evidenzniveau), hochfrequente rTMS des rechten DLPFC bei Patienten mit posttraumatischer Belastungsstörung und hochfrequente rTMS des linken DLPFC bei Nikotinabhängigkeit. Gerade bei der Behandlung von Patienten mit chronischem und therapieresistentem Erkrankungsverlauf ist zu erwarten, dass dem gesamten Bereich neurostimulatorischer Methoden eine steigende Bedeutung zukommen wird. Es bleibt zu hoffen, dass vor dem Hintergrund innovativer technischer Entwicklungen und verbesserter Studienmethodologie die transkranielle Magnetstimulation in der nahen Zukunft ihr volles therapeutisches Potenzial entfalten wird.

Summary

Transcranial magnetic stimulation (TMS) is a neuromodulatory technique consisting of short electromagnetic stimuli of approx. 2 Tesla produced by a stimulator connected to a coil. These magnetic fields penetrate the skull painlessly resulting in a depolarization of cortical neurons. The power of the magnetic field at the target area is mainly determined by a variety of physical and biological parameters such as coil geometry, coil position, coil distance to cortical target, pulse form, stimulation intensity, frequency, stimulation pattern, threedimensional orientation of cortical target in relation to the geometry of the applied magnetic field. Repetitive transcranial magnetic stimulation (rTMS) means the serial application of several electromagnetic stimuli at a given repetition rate. rTMS is able to evoke lasting changes in neuronal activity by induction of neuroplastic activity. The aim of the presented special issue is to provide a comprehensive overview regarding established and potential therapeutic applications of rTMS in the treatment of psychiatric disorders. A level-A-recommendation (“definitively effective”) is obtained for high-frequency stimulation of the left dorsolateral prefrontal cortex (DLPFC) in depressive disorders. Level-B-evidence (“probably effective”) is available for: (i) low-frequency rTMS of the right DLPFC in depressive disorders and (ii) high-frequency rTMS of the left DLPFC in case of depressive symptoms in patients suffering from Parkinson’s disease (probably additive effect of rTMS to antidepressant medication). Level-C-evidence (“possibly effective”) is available for: high-frequency rTMS of the left DLPFC in the treatment of negative symptoms in schizophrenic patients (despite a large multicenter- trial with negative findings), low-frequency rTMS of the left temporoparietal cortex in chronic tinnitus and acoustic halluzinations (low level of evidence despite a large number of publications), high-frequency stimulation of the right DLPFC in posttraumatic stress disorder (PTSD), and high-frequency rTMS of the left DLPFC in nicotine craving. It is very likely that – especially in the treatment of patients with chronic and treatment resistant conditions – the whole spectrum of neuromodulatory treatments will obtain increasing importance in the future. Innovative technical advances and improved study methodology may increase the potential of repetitive transcranial magnetic stimulation as an innovative and noninvasive treatment approach.

Schlüsselwörter

Transkranielle Magnetstimulation - TMS - Psychiatrie

Keywords

Transcranial magnetic stimulation - TMS - psychiatry

* Dieses Manuskript wurde als Positionspapier der Deutschen Gesellschaft für Hirnstimulation in der Psychiatrie (DGHP) erarbeitet.


 

  • Literatur

  • 1 Barker AT, Jalinous R, Freeston IL. Non-invasive magnetic stimulation of human motor cortex. Lancet 1985; 01 (8437): 1106-7.
    Search in Google Scholar
  • 2 Barker AT. The history and basic principles of magnetic nerve stimulation. Electroencephalogr Clin Neurophysiol Suppl 1999; 51: 3-21.
    PubMedSearch in Google Scholar
  • 3 Rossini PM, Burke D, Chen R, Cohen LG, Daskalakis Z, Di Iorio R. et al. Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: Basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee. Clin Neurophysiol. 2015 Feb 10.; E-pub.
    PubMedSearch in Google Scholar
  • 4 Chen R, Cros D, Curra A, Di Lazzaro V, Lefaucheur JP, Magistris MR. et al. The clinical diagnostic utility of transcranial magnetic stimulation: report of an IFCN committee. Clin Neurophysiol 2008; 119 (03) 504-32.
    CrossrefPubMedSearch in Google Scholar
  • 5 Thielscher A, Kammer T. Electric field properties of two commercial figure-8 coils in TMS: calculation of focality and efficiency. Clin Neurophysiol 2004; 115 (07) 1697-708.
    CrossrefPubMedSearch in Google Scholar
  • 6 Roth Y, Amir A, Levkovitz Y, Zangen A. Three-dimensional distribution of the electric field induced in the brain by transcranial magnetic stimulation using figure-8 and deep H-coils. J Clin Neurophysiol 2007; 24 (01) 31-8.
    CrossrefPubMedSearch in Google Scholar
  • 7 Deng ZD, Peterchev AV, Lisanby SH. Coil design considerations for deep-brain transcranial magnetic stimulation (dTMS). Conf Proc IEEE Eng Med Biol Soc 2008; 5675-9.
    Search in Google Scholar
  • 8 Salvador R, Miranda PC, Roth Y, Zangen A. High permeability cores to optimize the stimulation of deeply located brain regions using transcranial magnetic stimulation. Phys Med Biol 2009; 54 (10) 3113-28.
    CrossrefPubMedSearch in Google Scholar
  • 9 Sommer M, Alfaro A, Rummel M, Speck S, Lang N, Tings T. et al. Half sine, monophasic and biphasic transcranial magnetic stimulation of the human motor cortex. Clin Neurophysiol 2006; 117 (04) 838-44.
    CrossrefPubMedSearch in Google Scholar
  • 10 Sommer M, Lang N, Tergau F, Paulus W. Neuronal tissue polarization induced by repetitive transcranial magnetic stimulation?. Neuroreport 2002; 13 (06) 809-11.
    CrossrefPubMedSearch in Google Scholar
  • 11 Arai N, Okabe S, Furubayashi T, Terao Y, Yuasa K, Ugawa Y. Comparison between short train, monophasic and biphasic repetitive transcranial magnetic stimulation (rTMS) of the human motor cortex. Clin Neurophysiol 2009; 116 (03) 605-13.
    Search in Google Scholar
  • 12 Taylor JL, Loo CK. Stimulus waveform influences the efficacy of repetitive transcranial magnetic stimulation. J Affect Disord 2007; 97 (1–3): 271-6.
    CrossrefPubMedSearch in Google Scholar
  • 13 Arai N, Okabe S, Furubayashi T, Mochizuki H, Iwata NK, Hanajima R. et al. Differences in aftereffect between monophasic and biphasic high-frequency rTMS of the human motor cortex. Clin Neurophysiol 2007; 118 (10) 2227-33.
    CrossrefPubMedSearch in Google Scholar
  • 14 Sakai K, Ugawa Y, Terao Y, Hanajima R, Furubayashi T, Kanazawa I. Preferential activation of different I waves by transcranial magnetic stimulation with a figure-of-eight-shaped coil. Exp Brain Res 1997; 113 (01) 24-32.
    CrossrefPubMedSearch in Google Scholar
  • 15 Di Lazzaro V, Oliviero A, Profice P, Saturno E, Pilato F, Insola A. et al. Comparison of descending volleys evoked by transcranial magnetic and electric stimulation in conscious humans. Electroencephalogr Clin Neurophysiol 1998; 109 (05) 397-401.
    CrossrefPubMedSearch in Google Scholar
  • 16 Di Lazzaro V, Oliviero A, Pilato F, Saturno E, Dileone M, Mazzone P. et al. The physiological basis of transcranial motor cortex stimulation in conscious humans. Clin Neurophysiol 2004; 115 (02) 255-66.
    CrossrefPubMedSearch in Google Scholar
  • 17 Di Lazzaro V, Oliviero A, Pilato F, Mazzone P, Insola A, Ranieri F. et al. Corticospinal volleys evoked by transcranial stimulation of the brain in conscious humans. Neurol Res 2003; 25 (02) 143-50.
    CrossrefPubMedSearch in Google Scholar
  • 18 Lefaucheur JP. Principles of therapeutic use of transcranial and epidural cortical stimulation. Clin Neurophysiol 2008; 119 (10) 2179-84.
    CrossrefPubMedSearch in Google Scholar
  • 19 Di Lazzaro V, Ziemann U, Lemon RN. State of the art: Physiology of transcranial motor cortex stimulation. Brain Stimul 2008; 01 (04) 345-62.
    CrossrefPubMedSearch in Google Scholar
  • 20 Pascual-Leone A, Houser CM, Grafman J, Hallett M. Reaction time and transcranial magnetic stimulation. Lancet 1992; 339 (8806): 1420.
    CrossrefPubMedSearch in Google Scholar
  • 21 Pascual-Leone A, Valls-Sole J, Brasil-Neto JP, Cohen LG, Hallett M. Seizure induction and transcranial magnetic stimulation. Lancet 1992; 339 (8799): 997.
    CrossrefPubMedSearch in Google Scholar
  • 22 Pascual-Leone A, Valls-Sole J, Wassermann EM, Hallett M. Responses to rapid-rate transcranial magnetic stimulation of the human motor cortex. Brain 1994; 117: 847-58.
    CrossrefPubMedSearch in Google Scholar
  • 23 Lefaucheur JP. Methods of therapeutic cortical stimulation. Neurophysiol Clin 2009; 39 (01) 1-14.
    CrossrefPubMedSearch in Google Scholar
  • 24 Huang YZ, Edwards MJ, Rounis E, Bhatia KP, Rothwell JC. Theta burst stimulation of the human motor cortex. Neuron 2005; 45 (02) 201-6.
    CrossrefPubMedSearch in Google Scholar
  • 25 Hamada M, Murase N, Hasan A, Balaratnam M, Rothwell JC. The role of interneuron networks in driving human motor cortical plasticity. Cereb Cortex 2013; 23 (07) 1593-605.
    CrossrefPubMedSearch in Google Scholar
  • 26 Bliss TV, Lomo T. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol 1973; 232 (02) 331-56.
    CrossrefPubMedSearch in Google Scholar
  • 27 Malenka RC. Postsynaptic factors control the duration of synaptic enhancement in area CA1 of the hippocampus. Neuron 1991; 06 (01) 53-60.
    CrossrefPubMedSearch in Google Scholar
  • 28 Houdayer E, Degardin A, Cassim F, Bocquillon P, Derambure P, Devanne H. The effects of low-and high-frequency repetitive TMS on the input/output properties of the human corticospinal pathway. Exp Brain Res 2008; 187 (02) 207-17.
    CrossrefPubMedSearch in Google Scholar
  • 29 Di Lazzaro V, Dileone M, Pilato F, Capone F, Musumeci G, Ranieri F. et al. Modulation of motor cortex neuronal networks by rTMS: comparison of local and remote effects of six different protocols of stimulation. J Neurophysiol 2011; 105 (05) 2150-6.
    CrossrefPubMedSearch in Google Scholar
  • 30 Daskalakis ZJ, Moller B, Christensen BK, Fitzgerald PB, Gunraj C, Chen R. The effects of repetitive transcranial magnetic stimulation on cortical inhibition in healthy human subjects. Exp Brain Res 2006; 174 (03) 403-12.
    CrossrefPubMedSearch in Google Scholar
  • 31 Siebner HR, Lang N, Rizzo V, Nitsche MA, Paulus W, Lemon RN. et al. Preconditioning of low-frequency repetitive transcranial magnetic stimulation with transcranial direct current stimulation: evidence for homeostatic plasticity in the human motor cortex. J Neurosci 2004; 24 (13) 3379-85.
    CrossrefPubMedSearch in Google Scholar
  • 32 Lang N, Siebner HR, Ernst D, Nitsche MA, Paulus W, Lemon RN. et al. Preconditioning with transcranial direct current stimulation sensitizes the motor cortex to rapid-rate transcranial magnetic stimulation and controls the direction of after-effects. Biol Psychiatry 2004; 56 (09) 634-9.
    CrossrefPubMedSearch in Google Scholar
  • 33 Lefaucheur JP, Drouot X, Menard-Lefaucheur I, Keravel Y, Nguyen JP. Motor cortex rTMS restores defective intracortical inhibition in chronic neuropathic pain. Neurology 2006; 67 (09) 1568-74.
    CrossrefPubMedSearch in Google Scholar
  • 34 Bienenstock EL, Cooper LN, Munro PW. Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex. J Neurosci 1982; 02 (01) 32-48.
    CrossrefPubMedSearch in Google Scholar
  • 35 Abraham WC, Tate WP. Metaplasticity: a new vista across the field of synaptic plasticity. Prog Neurobiol 1997; 52 (04) 303-23.
    CrossrefPubMedSearch in Google Scholar
  • 36 Turrigiano GG, Nelson SB. Homeostatic plasticity in the developing nervous system. Nat Rev Neurosci 2004; 05 (02) 97-107.
    CrossrefPubMedSearch in Google Scholar
  • 37 Ridding MC, Ziemann U. Determinants of the induction of cortical plasticity by non-invasive brain stimulation in healthy subjects. J Physiol 2010; 588: 2291-304.
    CrossrefPubMedSearch in Google Scholar
  • 38 Hoogendam JM, Ramakers GM, Di Lazzaro V. Physiology of repetitive transcranial magnetic stimulation of the human brain. Brain Stimul 2010; 03 (02) 95-118.
    CrossrefPubMedSearch in Google Scholar
  • 39 Modugno N, Nakamura Y, MacKinnon CD, Filipovic SR, Bestmann S, Berardelli A. et al. Motor cortex excitability following short trains of repetitive magnetic stimuli. Exp Brain Res 2001; 140 (04) 453-9.
    CrossrefPubMedSearch in Google Scholar
  • 40 Peinemann A, Reimer B, Loer C, Quartarone A, Munchau A, Conrad B. et al. Long-lasting increase in corticospinal excitability after 1800 pulses of subthreshold 5 Hz repetitive TMS to the primary motor cortex. Clin Neurophysiol 2004; 115 (07) 1519-26.
    CrossrefPubMedSearch in Google Scholar
  • 41 Chen R, Classen J, Gerloff C, Celnik P, Wassermann EM, Hallett M. et al. Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation. Neurology 1997; 48 (05) 1398-403.
    CrossrefPubMedSearch in Google Scholar
  • 42 Maeda F, Keenan JP, Tormos JM, Topka H, Pascual-Leone A. Modulation of corticospinal excitability by repetitive transcranial magnetic stimulation. Clin Neurophysiol 2000; 111 (05) 800-5.
    CrossrefPubMedSearch in Google Scholar
  • 43 Touge T, Gerschlager W, Brown P, Rothwell JC. Are the after-effects of low-frequency rTMS on motor cortex excitability due to changes in the efficacy of cortical synapses?. Clin Neurophysiol 2001; 112 (11) 2138-45.
    CrossrefPubMedSearch in Google Scholar
  • 44 Gangitano M, Valero-Cabre A, Tormos JM, Mottaghy FM, Romero JR, Pascual-Leone A. Modulation of input-output curves by low and high frequency repetitive transcranial magnetic stimulation of the motor cortex. Clin Neurophysiol 2002; 113 (08) 1249-57.
    CrossrefPubMedSearch in Google Scholar
  • 45 Houze B, Bradley C, Magnin M, Garcia-Larrea L. Changes in sensory hand representation and pain thresholds induced by motor cortex stimulation in humans. Cereb Cortex 2013; 23 (11) 2667-76.
    CrossrefPubMedSearch in Google Scholar
  • 46 Bear MF, Kirkwood A. Neocortical long-term potentiation. Curr Opin Neurobiol 1993; 03 (02) 197-202.
    CrossrefPubMedSearch in Google Scholar
  • 47 Morris GL. A retrospective analysis of the effects of magnet-activated stimulation in conjunction with vagus nerve stimulation therapy. Epilepsy Behav 2003; 04 (06) 740-5.
    CrossrefPubMedSearch in Google Scholar
  • 48 Beuter A, Lefaucheur JP, Modolo J. Closed-loop cortical neuromodulation in Parkinson’s disease: An alternative to deep brain stimulation?. Clin Neurophysiol 2014; 125 (05) 874-85.
    CrossrefPubMedSearch in Google Scholar
  • 49 Fox P, Ingham R, George MS, Mayberg H, Ingham J, Roby J. et al. Imaging human intra-cerebral connectivity by PET during TMS. Neuroreport 1997; 08 (12) 2787-91.
    CrossrefPubMedSearch in Google Scholar
  • 50 Siebner H, Peller M, Lee L. TMS and positron emission tomography: methods and current advances. In: Wassermann E. et al. (eds.). The Oxford Handbook of Transcranial Magnetic Stimulation. Oxford: Oxford University Press; 2008: 549-67.
    Search in Google Scholar
  • 51 Lefaucheur JP. Neurophysiology of cortical stimulation. Int Rev Neurobiol 2012; 107: 57-85.
    PubMedSearch in Google Scholar
  • 52 Ferbert A, Priori A, Rothwell JC, Day BL, Colebatch JG, Marsden CD. Interhemispheric inhibition of the human motor cortex. J Physiol 1992; 453: 525-46.
    CrossrefPubMedSearch in Google Scholar
  • 53 Hanajima R, Ugawa Y, Machii K, Mochizuki H, Terao Y, Enomoto H. et al. Interhemispheric facilitation of the hand motor area in humans. J Physiol 2001; 531: 849-59.
    CrossrefPubMedSearch in Google Scholar
  • 54 Mochizuki H, Terao Y, Okabe S, Furubayashi T, Arai N, Iwata NK. et al. Effects of motor cortical stimulation on the excitability of contralateral motor and sensory cortices. Exp Brain Res 2004; 158 (04) 519-26.
    PubMedSearch in Google Scholar
  • 55 Bestmann S, Baudewig J, Siebner HR, Rothwell JC, Frahm J. BOLD MRI responses to repetitive TMS over human dorsal premotor cortex. Neuroimage 2005; 28 (01) 22-9.
    CrossrefPubMedSearch in Google Scholar
  • 56 Keck ME, Sillaber I, Ebner K, Welt T, Toschi N, Kaehler ST. et al. Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain. Eur J Neurosci 2000; 12 (10) 3713-20.
    CrossrefPubMedSearch in Google Scholar
  • 57 Keck ME, Welt T, Muller MB, Erhardt A, Ohl F, Toschi N. et al. Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system. Neuropharmacology 2002; 43 (01) 101-9.
    CrossrefPubMedSearch in Google Scholar
  • 58 Strafella AP, Paus T, Barrett J, Dagher A. Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleus. J Neurosci 2001; 21 (15) RC157.
    CrossrefPubMedSearch in Google Scholar
  • 59 Strafella AP, Paus T, Fraraccio M, Dagher A. Striatal dopamine release induced by repetitive transcranial magnetic stimulation of the human motor cortex. Brain 2003; 126: 2609-15.
    CrossrefPubMedSearch in Google Scholar
  • 60 Ohnishi T, Hayashi T, Okabe S, Nonaka I, Matsuda H, Iida H. et al. Endogenous dopamine release induced by repetitive transcranial magnetic stimulation over the primary motor cortex: an [11C]raclopride positron emission tomography study in anesthetized macaque monkeys. Biol Psychiatry 2004; 55 (05) 484-9.
    CrossrefPubMedSearch in Google Scholar
  • 61 Kim JY, Chung EJ, Lee WY, Shin HY, Lee GH, Choe YS. et al. Therapeutic effect of repetitive transcranial magnetic stimulation in Parkinson’s disease: analysis of [11C] raclopride PET study. Mov Disord 2008; 23 (02) 207-11.
    CrossrefPubMedSearch in Google Scholar
  • 62 Antal A, Kincses TZ, Nitsche MA, Bartfai O, Paulus W. Excitability changes induced in the human primary visual cortex by transcranial direct current stimulation: direct electrophysiological evidence. Invest Ophthalmol Vis Sci 2004; 45 (02) 702-7.
    CrossrefPubMedSearch in Google Scholar
  • 63 Hrobjartsson A, Gotzsche PC. Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N Engl J Med 2001; 344 (21) 1594-602.
    CrossrefPubMedSearch in Google Scholar
  • 64 Loo CK, Taylor JL, Gandevia SC, McDarmont BN, Mitchell PB, Sachdev PS. Transcranial magnetic stimulation (TMS) in controlled treatment studies: are some “sham” forms active?. Biol Psychiatry 2000; 47 (04) 325-31.
    CrossrefPubMedSearch in Google Scholar
  • 65 Lisanby SH, Gutman D, Luber B, Schroeder C, Sackeim HA. Sham TMS: intracerebral measurement of the induced electrical field and the induction of motor-evoked potentials. Biol Psychiatry 2001; 49 (05) 460-3.
    CrossrefPubMedSearch in Google Scholar
  • 66 Dollfus S, Lecardeur L, Morello R, Etard O. Placebo Response in Repetitive Transcranial Magnetic Stimulation Trials of Treatment of Auditory Hallucinations in Schizophrenia: A Meta-Analysis. Schizophr Bull. 2015 Jun 18; E-pub.
    PubMedSearch in Google Scholar
  • 67 O’Reardon JP, Solvason HB, Janicak PG, Sampson S, Isenberg KE, Nahas Z. et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol Psychiatry 2007; 62 (11) 1208-16.
    CrossrefPubMedSearch in Google Scholar
  • 68 Rossi S, Ferro M, Cincotta M, Ulivelli M, Bartalini S, Miniussi C. et al. A real electro-magnetic placebo (REMP) device for sham transcranial magnetic stimulation (TMS). Clin Neurophysiol 2007; 118 (03) 709-16.
    CrossrefPubMedSearch in Google Scholar
  • 69 Mennemeier M, Triggs W, Chelette K, Woods A, Kimbrell T, Dornhoffer J. Sham Transcranial Magnetic Stimulation Using Electrical Stimulation of the Scalp. Brain Stimul 2009; 02 (03) 168-73.
    CrossrefPubMedSearch in Google Scholar
  • 70 Arana AB, Borckardt JJ, Ricci R, Anderson B, Li X, Linder KJ. et al. Focal electrical stimulation as a sham control for repetitive transcranial magnetic stimulation: Does it truly mimic the cutaneous sensation and pain of active prefrontal repetitive transcranial magnetic stimulation?. Brain Stimul 2008; 01 (01) 44-51.
    CrossrefPubMedSearch in Google Scholar
  • 71 Zunhammer M, Busch V, Griesbach F, Landgrebe M, Hajak G, Langguth B. rTMS over the cerebellum modulates temperature detection and pain thresholds through peripheral mechanisms. Brain Stimul 2011; 04 (04) 210-7. e1.
    CrossrefPubMedSearch in Google Scholar
  • 72 Okabe S, Ugawa Y, Kanazawa I. 0.2-Hz repetitive transcranial magnetic stimulation has no add-on effects as compared to a realistic sham stimulation in Parkinson’s disease. Mov Disord 2003; 18 (04) 382-8.
    CrossrefPubMedSearch in Google Scholar
  • 73 Tamura Y, Okabe S, Ohnishi T, D NS Arai N, Mochio S. et al. Effects of 1-Hz repetitive transcranial magnetic stimulation on acute pain induced by capsaicin. Pain 2004; 107 (1–2): 107-15.
    CrossrefPubMedSearch in Google Scholar
  • 74 Colloca L, Benedetti F. How prior experience shapes placebo analgesia. Pain 2006; 124 (1–2): 126-33.
    CrossrefPubMedSearch in Google Scholar
  • 75 Petrovic P, Kalso E, Petersson KM, Ingvar M. Placebo and opioid analgesia – imaging a shared neuronal network. Science 2002; 295 (5560): 1737-40.
    CrossrefPubMedSearch in Google Scholar
  • 76 Benedetti F, Mayberg HS, Wager TD, Stohler CS, Zubieta JK. Neurobiological mechanisms of the placebo effect. J Neurosci 2005; 25 (45) 10390-402.
    CrossrefPubMedSearch in Google Scholar
  • 77 Andre-Obadia N, Magnin M, Garcia-Larrea L. On the importance of placebo timing in rTMS studies for pain relief. Pain 2011; 152 (06) 1233-7.
    CrossrefPubMedSearch in Google Scholar
  • 78 Rossi S, De Capua A, Ulivelli M, Bartalini S, Falzarano V, Filippone G. et al. Effects of repetitive transcranial magnetic stimulation on chronic tinnitus: a randomised, crossover, double blind, placebo controlled study. J Neurol Neurosurg Psychiatry 2007; 78 (08) 857-63.
    CrossrefPubMedSearch in Google Scholar
  • 79 Lefaucheur JP, Andre-Obadia N, Antal A, Ayache SS, Baeken C, Benninger DH. et al. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS). Clin Neurophysiol 2014; 125 (11) 2150-206.
    CrossrefPubMedSearch in Google Scholar
  • 80 Brainin M, Barnes M, Baron JC, Gilhus NE, Hughes R, Selmaj K. et al. Guidance for the preparation of neurological management guidelines by EFNS scientific task forces – revised recommendations 2004. Eur J Neurol 2004; 11 (09) 577-81.
    CrossrefPubMedSearch in Google Scholar