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Schlaf 2013; 2(04): 202-206
DOI: 10.1055/s-0038-1626077
REVIEW Schlaf & Endokrinologie
Schattauer GmbH

Schlafendokrinologie

Axel Steiger
1   Max-Planck-Institut für Psychiatrie Kraepelinstr. 2–10 80804 München, eMail: steiger@mpipsykl.mpg.de
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Publikationsverlauf

Publikationsdatum:
10. Februar 2018 (online)

    Lizenzen und Reprints

Schlaf ist eine Zeit hoher Aktivität in endokrinen Systemen. Entsprechend besteht eine bidirektionale Interaktion zwischen der elektrophysiologischen und der endokrinen Komponente des Schlafs, die sich simultan mit Polysomnographie und nächtlichen Blutabnahmen zur späteren Hormonbestimmung erfassen lassen. Klinische Studien, Humanexperimente und Tiermodelle zeigen, dass Neuropeptide und Steroide eine wichtige Rolle in der normalen Schlafregulation spielen. Bei endokrinologischen Erkrankungen und der Depression trägt die gestörte Hormonsekretion zu Veränderungen der Schlafstruktur bei. Eine reziproke Interaktion zwischen den Neuropeptiden Wachstumshormon-freisetzendes Hormon (GHRH) und Corticotropin-freisetzendes Hormon (CRH) spielt eine Schlüsselrolle in der Schlafregulation.

 

  • Literatur

  • 1 Antonijevic IA, Murck H, Frieboes RM, Holsboer F, Steiger A. On the gender differences in sleep-endocrine regulation in young normal humans. Neuroendocrinology 1999; 70: 280-287.
    CrossrefPubMedGoogle Scholar
  • 2 Antonijevic IA, Stalla GK, Steiger A. Modulation of the sleep electroencephalogram by estrogen replacement in postmenopausal women. American Journal of Obstetrics & Gynecology 2000a 182: 277-282.
    Google Scholar
  • 3 Antonijevic IA, Murck H, Bohlhalter S, Frieboes RM, Holsboer F, Steiger A. NPY promotes sleep and inhibits ACTH and cortisol release in young men. Neuropharmacology 2000b 39: 1474-1481.
    Google Scholar
  • 4 Antonijevic IA, Steiger A. Depression-like changes of the sleep-EEG during high dose corticosteroid treatment in patients with multiple sclerosis. Psychoneuroendocrinology 2003; 28: 780-795.
    CrossrefPubMedGoogle Scholar
  • 5 Åström C, Lindholm J. Growth hormone-deficient young adults have decreased deep sleep. Neuroendocrinology 1990; 51: 82-84.
    CrossrefPubMedGoogle Scholar
  • 6 Åström C, Trojaborg W. Effect of growth hormone on human sleep energy. Clinical Endocrinology 1992; 36: 241-245.
    CrossrefPubMedGoogle Scholar
  • 7 Born J, Fehm HL. Hypothalamus-pituitary-adrenal activity during human sleep: a coordinating role for the limbic hippocampal system. Experimental and Clinical Endocrinology & Diabetes 1998; 106: 153-163.
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 8 Desir D, Van Cauter E, Fang VS, Martino E, Jadot C, Spire JP, Noel P, Refetoff S, Copinschi G, Golstein J. Effects of „jet lag“ on hormonal patterns. I. Procedures, variations in total plasma proteins, and disruption of adrenocorticotropin-cortisol periodicity. Journal of Clinical Endocrinology & Metabolism 1981; 52: 628-641.
    PubMedGoogle Scholar
  • 9 Friess E, von Bardeleben U, Wiedemann K, Lauer C, Holsboer F. Effects of pulsatile cortisol infusion on sleep-EEG and nocturnal growth hormone release in healthy men. Journal of Sleep Research 1994; 3: 73-79.
    CrossrefPubMedGoogle Scholar
  • 10 Friess E, Trachsel L, Guldner J, Schier T, Steiger A, Holsboer F. DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency range. American Journal of Physiology: Endocrinology and Metabolism 1995; 268: E107-E113.
    CrossrefPubMedGoogle Scholar
  • 11 Guilhaume A, Benoit O, Gourmelen M, Richardet JM. Relationship between sleep stage IV deficit and reversible hGH deficiency in psychosocial dwarfism. Pediatric Research 1982; 16: 299-303.
    CrossrefPubMedGoogle Scholar
  • 12 Held K, Künzel H, Ising M, Schmid DA, Zobel A, Murck H, Holsboer F, Steiger A. Treatment with the CRH1-receptor antagonist R121919 improves sleep EEG in patients with depression. Journal of Psychiatric Research 2004; 38: 129-136.
    CrossrefPubMedGoogle Scholar
  • 13 Holsboer F, von Bardeleben U, Steiger A. Effects of intravenous corticotropin-releasing hormone upon sleep-related growth hormone surge and sleep EEG in man. Neuroendocrinology 1988; 48: 32-38.
    CrossrefPubMedGoogle Scholar
  • 14 Kimura M, Müller-Preuss P, Lu A, Wiesner E, Flachskamm C, Wurst W, Holsboer F, Deussing JM. Conditional corticotropin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep. Molecular Psychiatry 2010; 15: 154-165.
    CrossrefPubMedGoogle Scholar
  • 15 Murck H, Guldner J, Colla-Müller M, Frieboes RM, Schier T, Wiedemann K, Holsboer F, Steiger A. VIP decelerates non-REM-REM cycles and modulates hormone secretion during sleep in men. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 1996; 271: R905-R911.
    CrossrefPubMedGoogle Scholar
  • 16 Murck H, Antonijevic IA, Frieboes RM, Maier P, Schier T, Steiger A. Galanin has REM-sleep deprivation-like effects on the sleep EEG in healthy young men. Journal of Psychiatric Research 1999; 33: 225-232.
    CrossrefPubMedGoogle Scholar
  • 17 Obál Jr. F, Krueger JM. GHRH and sleep. Sleep Medicine Reviews 2004; 8: 367-377.
    CrossrefPubMedGoogle Scholar
  • 18 Saper CB, Chou TC, Scammell TE. The sleep switch: hypothalamic control of sleep and wakefulness. Trends in Neurosciences 2001; 24: 726-731.
    CrossrefPubMedGoogle Scholar
  • 19 Sassin JF, Parker DC, Mace JW, Gotlin RW, Johnson LC, Rossman LG. Human growth hormone release: relation to slow-wave sleep and sleep-waking cycles. Science 1969; 165: 513-515.
    CrossrefPubMedGoogle Scholar
  • 20 Schüssler P, Kluge M, Yassouridis A, Dresler M, Held K, Zihl J, Steiger A. Progesterone reduces wakefulness in sleep EEG and has no effect on cognition in healthy postmenopausal women. Psychoneuroendocrinology 2008; 33: 1124-1131.
    CrossrefPubMedGoogle Scholar
  • 21 Schüssler P, Kluge M, Dresler M, Yassouridis A, Steiger A. Sleep-impairing effect of intravenous corticotropin-releasing hormone on sleep EEG in young healthy women. Experimental and Clinical Endocrinology & Diabetes 2009; 117: 664.
    Google Scholar
  • 22 Shipley JE, Schteingart DE, Tandon R, Starkman MN. Sleep architecture and sleep apnea in patients with Cushing’s disease. Sleep 1992; 15: 514-518.
    CrossrefPubMedGoogle Scholar
  • 23 Steiger A, Herth T, Holsboer F. Sleep-electroencephalography and the secretion of cortisol and growth hormone in normal controls. Acta Endocrinologica (Copenhagen) 1987; 116: 36-42.
    Google Scholar
  • 24 Steiger A, Guldner J, Hemmeter U, Rothe B, Wiedemann K, Holsboer F. Effects of growth hormone-releasing hormone and somatostatin on sleep EEG and nocturnal hormone secretion in male controls. Neuroendocrinology 1992; 56: 566-573.
    CrossrefPubMedGoogle Scholar
  • 25 Steiger A, Rupprecht R, Spengler D, Guldner J, Hemmeter U, Rothe B, Damm K, Holsboer F. Functional properties of deoxycorticosterone and spironolactone: molecular characterization and effects on sleep-endocrine activity. Journal of Psychiatric Research 1993; 27: 275-284.
    CrossrefPubMedGoogle Scholar
  • 26 Steiger A. Neurochemical regulation of sleep. Journal of Psychiatric Research 2007; 41: 537-552.
    CrossrefPubMedGoogle Scholar
  • 27 Steiger A, Kimura M. Wake and sleep EEG provide biomarkers in depression. Journal of Psychiatric Research 2010; 44: 242-252.
    CrossrefPubMedGoogle Scholar
  • 28 Steiger A, Dresler M, Schüssler P, Kluge M. Ghrelin in mental health, sleep, memory. Molecular & Cellular Endocrinology 2011; 340: 88-96.
    CrossrefPubMedGoogle Scholar
  • 29 Weibel L, Brandenberger G. Disturbances in hormonal profiles of night workers during their usual sleep and work times. Journal of Biological Rhythms 1998; 13: 202-208.
    CrossrefPubMedGoogle Scholar