PDF herunterladen
Nuklearmedizin 1973; 12(01): 26-34
DOI: 10.1055/s-0038-1624805
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

Radioiodine Uptake Values in Euthyroid, Non-Goitrous, Prepubertal Children in Greece

Les valeurs de fixation dans des enfants non-goitreux, euthyroïdiens prépubertaires en GreceRadiojodspeicherwerte bei euthyreoten, präpubertären kropflosen Kindern in Griechenland
Ch. Anoussakis
1   From the 2nd Department of the Childrens Hospital „Aglaia Kyriakou“ (Head: Ass. Prof. D. Liakakos)
,
D. Liakakos
1   From the 2nd Department of the Childrens Hospital „Aglaia Kyriakou“ (Head: Ass. Prof. D. Liakakos)
,
D. Ikkos
1   From the 2nd Department of the Childrens Hospital „Aglaia Kyriakou“ (Head: Ass. Prof. D. Liakakos)
,
P. Vlachos
1   From the 2nd Department of the Childrens Hospital „Aglaia Kyriakou“ (Head: Ass. Prof. D. Liakakos)
,
S. Gonticas
1   From the 2nd Department of the Childrens Hospital „Aglaia Kyriakou“ (Head: Ass. Prof. D. Liakakos)
,
P. Matsioulas
1   From the 2nd Department of the Childrens Hospital „Aglaia Kyriakou“ (Head: Ass. Prof. D. Liakakos)
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received:23. November 1972

Publikationsdatum:
24. Januar 2018 (online)

    Lizenzen und Reprints

La fixation thyroïdienne du 131I a été mesurée en 50 enfants non-goitreux agés de 2 à 12 ans (17 masculins, 33 féminins). Les valeurs de fixation des enfants grèques (l’erreur standard ± pour les deux sexes était 38,8 ± 1,81; 59,1 ± 2,17; 60,2 ± 2,16 à 3, 24 et 48 heures) sont les plus élevées rapportées jusqu’à maintenant das la litérature donnant preuve à la pénurie de l’iode dans notre pays. Une autre manifestation de la pénurie de l’iode était l’observation, que dans 41% des enfants prépubertaires les valeurs PB 131I à 48 heures étaient plus élevées que la limite supérieure normale de 0,4% par litre.

Les enfants féminines montraient des valeurs de fixation significativement (P < 0,05) plus élevées que les masculins avec un taux de différence des valeurs moyennes de 1,34; 1,19; et 1,15 à 3, 24 et 48 heures.

Summary

Thyroidal uptake of 1311 was measured in 50 euthyroid, non-goitrous Greek children aged 2-12 years (17 males and 33 females).

The 131I uptake values of Greek children (mean ± standard error for both sexes of 31.8 ± 1.81, 59.1 ± 2.17 and 60.2 ± 2.16 at 3, 24 and 48 hrs respectively) are the highest recorded so far in the literature, a manifestation of the prevailing iodopenia in our country. Another manifestation of the iodopenia was the finding that in 41% of the prepubertal children the PB131I values at 48 hours were larger than the upper normal limit of 0.4 per cent of the dose/liter.

Female children had significantly higher (P < C 0,05) uptake values than male ones, the ratio of the mean values for females to the mean value for males being 1.34, 1.19 and 1.15 at 3, 24 and 48 hrs respectively.

Prepubertal children had significantly higher (P < C 0,05) uptake values than postpubertal ones, this difference being most pronounced in females, in whom the mean 131I uptake for the age group 12-20 was 30.5, 17.4 and 16.2% lower at 3, 24 and 48 hrs respectively, in comparison with the mean of the prepubertal age group.

Es wurde die Schilddrüsenspeicherung von 131J bei 50 (17 männlichen und 33 weiblichen) euthyreoten, präpubertären, kröpf losen griechischen Kindern im Alter von 2 bis 12 Jahren gemessen.

Die 131J-Speicherwerte bei griechischen Kindern (Mittelwert ± Standardfehler für beide Geschlechter: 31,3 ± 1,81, 59,1 ± 2,17 bzw. 60,2 ± 2,16 nach 3, 24 bzw. 48 Std.) sind die bisher höchsten, in der Literatur bekannten Werte, ein Symptom des in unserem Land herrschenden Jodmangels. Ein weiteres Symptom des Jodmangels war die Beobachtung, daß bei 4 1% der präpubertären Kinder der PB131 J-Wert nach 48 Std. höher war als die obere Grenze des Normalen von 0,4%> der Dosis pro Liter.

Weibliche Kinder zeigten signifikant (P <C 0,05) höhere Speicherwerte als die männlichen; das Verhältnis zwischen weiblichen und männlichen Mittelwerten betrug 1,34, 1,19 bzw. 1,15 nach 3, 24 bzw. 48 Std.

Die Speicherwerte waren vor der Pubertät signifikant (P <C 0,05) höher als nach der Pubertät, wobei der Unterschied bei den weiblichen Kindern deutlicher war; in der Altersgrenze 12—20 war der mittlere Speicherwert um 30,5, 17,4 bzw. 16,2% (nach 3, 24 bzw. 48 Std.) niedriger als der Mittelwert der präpubertären Altersgruppe.

 

  • References

  • 1 Andersen H. J. Studies of hypothyroidism in children. Acta Pediat. 50. Suppl 125
    Google Scholar
  • 2 Bernheim M, Berger M. Le diagnostic et le mécanisme de l'insuffisance thyroidienne de l'enfant étudiés À la faveur des épreuves au radioiode. Sem. Hôp. Paris. Ann. Pédiat 1954; 30: 3575
    Google Scholar
  • 3 Bloom P. S, Terstra J. High PB131I concentration in blood of patients with myxedema: preliminary report. J. clin. Endoer 1953; 13: 989
    CrossrefPubMedGoogle Scholar
  • 4 Börner W. Die Radiojodspeicherung der Schilddrüse in Abhängigkeit von Alter und Geschlecht. Klin. Wschr 1961; 39: 116
    CrossrefGoogle Scholar
  • 5 Correns H. J, Finck W. The dependence of the thyroid radioiodine test on age. Radiobiol. Radiother. (Berl.) 1963; 1: 35
    Google Scholar
  • 6 Danys P, Corbeel L, Van den Driessche A, De Visscher M, Beckers C, Drochmans A, De Roo M, Vanderschueren E. L'exploration fonctionnelle de la thyroide. 18e Congr. Ass. Pédiatres Langue Franç. Genève, S. Karger, Bâle, Vol. I, 1961; 44
    Google Scholar
  • 7 De Albuquerque D, Cordeiro II J. G, Ulyssca R, Barbosa de Souza R. Thyroid function in aged persons. Rev. Ass. méd. bras 1963; 9: 105
    PubMedGoogle Scholar
  • 8 Della Maggiore M, Pardelli L. II bilancio ormonale tiroideo nei bambini normali tra i 6 e i 10 anni. Folia endoc. (Roma) 1957; 10: 447
    Google Scholar
  • 9 Diwany M, Gabr M, Sallam F, Saadani M. A study of the 131I uptake in children, with special reference to the iodide repletion test. J. Pediat 1960; 57: 180
    CrossrefPubMedGoogle Scholar
  • 10 Fisher D. A. Thyroid function tests in childhood. In Werner S. C, and Ingbar S. H. Eds. The thyroid, a fundamental and clinical text. Harper and Row, Publishers; New York: Third Edition. 1971: 292
    Google Scholar
  • 11 Fisher D. A, Oddie T. H. Neonatal thyroid hyperactivity. Amer. J. Dis. Child 1964; 24: 733
    Google Scholar
  • 12 Fisher D. A, Oddie T. H, Burroughs J. C. Thyroidal Radioiodine uptake rate measurements in infants. Amer. J. Dis. Child. 103, 1962; 738
    Google Scholar
  • 13 Fisher D. A, Oddie T. H, Makoski E. J. The influence of environmental temperature on thyroid, adrenal and water metabolism in newborn human infant. Pediatrics 1966; 27: 583
    Google Scholar
  • 14 Fisher D. A, Oddie T. H, Wait J. C. Thyroid function tests. Findings in Arkansas Chidren and young adults. Amer. J. Dis. Child. 107, 1964; 282
    Google Scholar
  • 15 Friedman A. Radioiodine uptake in children with mongolism. Pediatrics 1955; 16: 55
    PubMedGoogle Scholar
  • 16 Gaffney G. W, Gregerman R. I, Shock N. W. Relationship age to the thyroidal accumulation, renal excretion and distribution of radioiodide in euthyroid man. J. clin. Endoer 1962; 22: 784
    CrossrefPubMedGoogle Scholar
  • 17 Goolden A. W. G. A comparison of radioiodine tests in the diagnosis of hyperthyroidism. Brit. Radiol 1958; 31: 433
    Google Scholar
  • 18 Hadjidakis S. G. Observations of goitre in Greece. Acta Pediat 1959; 48: 12
    Google Scholar
  • 19 Horst W, Harnack G.A.V. Hypothyreosen im Kindesalter. Dtsch. med. Wschr 1953; 78: 1259
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 20 Jaimet C. H, Rhode H. G. Thyroid function studies on children receiving cobalt therapy. J. Amer. Med. Ass 1955; 158: 1353
    CrossrefPubMedGoogle Scholar
  • 21 Koutras D. A, Alexander W. D, Buchanan W. W, Crooks J, Wayne E. J. Studies of stable iodine metabolism as a guide to the interpretation of radioiodine tests. Acta Endocr 1961; 37: 597
    PubMedGoogle Scholar
  • 22 Koutras D. A, Yataganas X. A. The iodine content of drinking water, milk and certain foods. Ann. Athens Acad 1967; 42: 216
    Google Scholar
  • 23 Krokowski E, Kunze H, Flehmig R, Rach K. Die normale Schilddrüsenfunktion im Radiojodtest in Abhängigkeit von Lebensalter und Geschlecht. Nucl. Med 1964; 3: 200
    Google Scholar
  • 24 Malamos B, Koutras D. A, Kostamis P, Kralios A. C, Rigopoulos G, Zerefos N. Endemic goiter in Greece. Epidemiologic and genetic studies. J. clin. Endocr 26: 688 1966; b
    PubMedGoogle Scholar
  • 25 Malamos B, Koutras D. A, Marketos S. G, Rigopoulos G. A, Yataganas X. A, Binopoulos D, Sfoutouris J. Endemic goiter in Greece; an iodine balance study in the field. J. clin. Endocr 1967; 27: 1327
    Google Scholar
  • 26 Malamos B, Miras K, Koutras D. A, Kostamis P, Binopoulos D, Mantzos J, Levis G, Rigopoulos G, Zerefou N, Tassopoulos C. N. Endemic goiter in Greece: metabolic studies. J. clin. Endocr 26: 696 1966; a
    CrossrefPubMedGoogle Scholar
  • 27 Malvaux P, Beckers C, De Visscher M. Dynamic studies on the inorganic iodide compartement and its exchange during adolescence. J. clin. Endocr 1965; 25: 817
    CrossrefPubMedGoogle Scholar
  • 28 McGavack T. H, Seegers W. Status of the thyroid gland after age 50. Metabolism 1959; 8: 136
    PubMedGoogle Scholar
  • 29 McHarden G. Quantitative isotopic tests of thyroid function, including tests of thyroid homeostasis. In Werner S, and Ingbar S. H. Eds. The Thyroid. A fundamental and Clinical Text. Harper and Row, Publishers; New York: Third Edition. 1971: 193
    Google Scholar
  • 30 Means J. H, De Groot L. J, Stanbury J. B. The Thyroid and its Diseases. McGraw-Hill Book Company., Inc.; New York: 1963
    Google Scholar
  • 31 Muttini P. La funzionalitÀ tiroidea esplorata con 131J nell'ete senile. Arch. E. Maragliano Pat. Clin 1967; 23: 151
    Google Scholar
  • 32 Oddie T. H, Myhill J, Pirnique F. G, Fisher D. A. Effect of age and sex radioiodine uptake in euthyroid subjects. J. clin. Endocr 1968; 28: 776
    CrossrefPubMedGoogle Scholar
  • 33 Oddie T. H, Pirnique F. G, Fisher D. A, Meade Jr. J. H.. Geographic variation of radioiodine uptake in euthyroid subjects. J. clin. Endocr 1968; 28: 761
    CrossrefPubMedGoogle Scholar
  • 34 Ogborn R. E, Waggener R. E, Vanttove E. Radioactive-iodine concentrations in thyroid glands of newborn infants. Pediatrics 1960; 21: 771
    Google Scholar
  • 35 Oliner L, Kohlenbrener R. M, Fields T, Kunstadter R. H. Thyroid function studies in children; normal values for thyroidal 131I uptake and PB131I levels up to the age of 18. J. clin. Endoer 1957; 17: 61
    CrossrefPubMedGoogle Scholar
  • 36 Perlmutter M, Riggs D. S. Thyroid collection of radioactive iodide and serum protein-bound iodine concentration in senencence, in hypothyroidism and in hypopituitarism. J. clin. Endoer 1949; 9: 430
    CrossrefPubMedGoogle Scholar
  • 37 Pouchon G, Beckers C, De Vissher M. Iodide kinetic studies in newborn and infants. J. clin. Endoer 1966; 26: 1392
    CrossrefPubMedGoogle Scholar
  • 38 Quimby E. H, McCune D. J. Uptake of radioactive iodine by the normal and disordered thyroid gland in chlidren. Radiology 1947; 49: 201
    CrossrefPubMedGoogle Scholar
  • 39 Quimby E. H, Werner S. C, Schmidt C. Influence of age, sex and season upon radioiodine uptake by the human thyroid. Proc. Soc. exp. Biol. (N. Y.) 1950; 75: 537
    CrossrefPubMedGoogle Scholar
  • 40 Reilly W. A, Bayer D. I. The value of the measurements of thyroid uptake and urinary excretion of 131I in assessing thyroid function of normal and congenitally hypothyroid children. J. Pediatr 1952; 49: 714
    Google Scholar
  • 41 Roche M, de Venanzi F, Vera J, Coll E, Berti Spinetti M, Mendez - Martinez J, Gerardi A, Foreros J. Endemic goiter in Venezuela studied with 131I. J. clin. Endoer 1957; 17: 99
    CrossrefPubMedGoogle Scholar
  • 42 Sheline G. E, Koulisher N, Pickering D. Thyroidal accumulation of radioiodine in children. Amer. J. Dis. Child. 93, 1957; 391
    Google Scholar
  • 43 Snedecor G. W, Cochran W. G. Statistical Methods. The Iowa University Press, Ames, Iowa, Sixth Edition 1971
    PubMedGoogle Scholar
  • 44 Stanbury J. B, Brownell G. L, Riggs D. S, Perinetti H, Itoiz J, del Castillo E. B. Endemic Goiter. The adaptation of Man to Iodine Deficiency. Harvard University Press; Cambridge: 1954
    Google Scholar
  • 45 Tubiana M, et Ravaud G. Resultats de 500 tests de fixation intrathyroidienne de l'iode radioactif chez l'enfant. Ann. Endoer. (Paris) 1956; 17: 175
    Google Scholar
  • 46 Wayne E. J, Koutras D. A, Alexander W. D. Clinical Aspects of Iodine Metabolism. Blackwell Scientific Publications, Oxford 1964
    PubMedGoogle Scholar
  • 47 Winikoff D, Taylor K. Oral contraceptives and thyroid function tests. Med. J. Aust 1966; 2: 108
    PubMedGoogle Scholar