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Thromb Haemost 2001; 86(05): 1176-1180
DOI: 10.1055/s-0037-1616047
Review Article
Schattauer GmbH

Myocardial Troponin T Release Is Associated with Enhanced Fibrinolysis in Patients with Acute Coronary Syndromes

Raila Ehlers
1   Medizinische Klinik, Abteilung III, Eberhard-Karls-Universität Tübingen, Germany
,
Eva Büttcher
1   Medizinische Klinik, Abteilung III, Eberhard-Karls-Universität Tübingen, Germany
,
Silke Kazmaier
1   Medizinische Klinik, Abteilung III, Eberhard-Karls-Universität Tübingen, Germany
,
Martin E. Beyer
1   Medizinische Klinik, Abteilung III, Eberhard-Karls-Universität Tübingen, Germany
,
Uwe Helber
1   Medizinische Klinik, Abteilung III, Eberhard-Karls-Universität Tübingen, Germany
,
Sebastian Szabo
1   Medizinische Klinik, Abteilung III, Eberhard-Karls-Universität Tübingen, Germany
,
Hans Peter Wendel
1   Medizinische Klinik, Abteilung III, Eberhard-Karls-Universität Tübingen, Germany
,
Hans Martin Hoffmeister
1   Medizinische Klinik, Abteilung III, Eberhard-Karls-Universität Tübingen, Germany
› Author Affiliations
Further Information

Publication History

Received 15 December 2000

Accepted after resubmission 20 July 2001

Publication Date:
13 December 2017 (online)

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Summary

Patients with acute coronary syndromes (ACS) frequently present with signs of disturbed fibrinolysis. The present study investigates the correlation of alterations in the fibrinolytic system and the amount of myocardial damage characterized by troponin release.

In 85 patients with ACS markers of plasmin activation, plasminogen activator system and troponin T (TnT) were measured initially and after 48 h. Patients with TnT release (≥ 0.01 g/l) at admission had higher TPA levels than those without release (10.2 ± 0.7 ng/ml vs. 7.6 ± 0.5 ng/ml; p <0.01). Additionally, patients with positive TnT had higher D-dimer levels initially (457 ± 39 ng/ml vs. 316 ± 22 ng/ml; p < 0.01) and 48 h later (451 ± 42 ng/ml vs. 275 ± 37 ng/ml; p < 0.01). The association of myocardial damage with a prothrombotic state and an enhanced fibrinolysis may explain the high prognostic value of troponin measurements in respect to future coronary events.

Keywords

Acute coronary syndromes - fibrinolytic system - plasminogen activator system - plasmin activation - troponin T
 

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