Download PDF
Thromb Haemost 2001; 85(04): 749-751
DOI: 10.1055/s-0037-1615668
Letters to the Editor
Schattauer GmbH

The Endothelial Protein C Receptor (EPCR) 23bp Insert in Patients with Myocardial Infarction

N. S. Van de Water
1   Department of Molecular Medicine, University of Auckland
2   Haematology Department, Auckland Hospital
,
J. K. French
1   Department of Molecular Medicine, University of Auckland
3   Cardiology Department, Green Lane Hospital, Auckland, New Zealand
,
J. McDowell
1   Department of Molecular Medicine, University of Auckland
,
P. J. Browett
1   Department of Molecular Medicine, University of Auckland
1   Department of Molecular Medicine, University of Auckland
› Author Affiliations
Further Information

Publication History

Received 03 November 2000

Accepted 06 November 2000

Publication Date:
08 December 2017 (online)

    Permissions and Reprints

 

 

  • References

  • 1 Lane DA, Grant PJ. Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease. Blood 2000; 95: 1517-32.
    PubMedGoogle Scholar
  • 2 Rosendaal FR, Siscovick DS, Schwartz SM, Beverly RK, Psaty BM, Longstreth Jr WT, Raghunathan TE, Koepsell TD, Reitsma PH. Factor V Leiden (resistance to activated protein C) increases the risk of myocardial infarction in young women. Blood 1997; 89 (Suppl. 08) 2817-21.
    PubMedGoogle Scholar
  • 3 Rosendaal FR, Siscovick DS, Schwartz SM, Psaty BM, Raghunathan TE, Vos HL. A common prothrombin variant (20210 G to A) increases the risk of myocardial infarction in young women. Blood 1997; 90 (Suppl. 05) 1747-50.
    PubMedGoogle Scholar
  • 4 Doggen CJ, Cats VM, Bertina RM, Rosendaal FR. Interaction of coagulation defects and cardiovascular risk factors: increased risk of myocardial infarction associated with factor V Leiden or prothrombin 20210A. Circulation 1998; 97 (Suppl. 11) 1037-41.
    CrossrefPubMedGoogle Scholar
  • 5 Dacosta A, Tardy-Pncet B, Isaaz K, Cerisier A, Mismetti P, Simitsidis S, Reynaud J, Tardy B, Piot M, Decousus H, Guyotat D. Prevalence of factor V Leiden (APCR) and other inherited thrombophilias in young patients with myocardial infarction and normal coronary arteries. Heart 1998; 80: 338-40.
    CrossrefPubMedGoogle Scholar
  • 6 Van de Water NS, French JK, Lund M, Hyde TA, White HD, Browett PJ. Prevalence of factor V Leiden and prothrombin variant G20210A in patients aged <50 years with no significant stenoses at angiography three to four weeks after myocardial infarction. J Am Coll Cardiol 2000; 36: 717-22.
    CrossrefPubMedGoogle Scholar
  • 7 Esmon CT, Owen WG. Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. Proc Natl Acad Sci USA 1981; 78: 2249-52.
    CrossrefPubMedGoogle Scholar
  • 8 Laszik Z, Mitro A, Taylor FB, Ferrell G, Esmon CT. Human protein C receptor is present primarily on endothelium of large blood vessels: Implications for the control of the protein C pathway. Circulation 1997; 96: 3633-40.
    CrossrefPubMedGoogle Scholar
  • 9 Fukudome K, Ye X, Tsuneyoshi N, Tokunga O, Sugawara K, Mizokami H, Kimoto M. Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor. J Exp Med 1998; 187: 1029-35.
    CrossrefPubMedGoogle Scholar
  • 10 Stearns-Kurosawa DJ, Kurosawa S, Mollica J, Ferrell GL, Esmon CT. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc Natl Acad Sci USA 1996; 93: 10212-6.
    CrossrefPubMedGoogle Scholar
  • 11 Simmonds RE, Lane D. Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: Comparison with the structure of CD1/major histocompatibility complex cd and α2 domains. Blood 1999; 94: 632-41.
    PubMedGoogle Scholar
  • 12 Merati G, Biguzzi E, Oganesyan N, Fetiveau R, Qu D, Bucciarelli P, Stearns-Kurosawa DJ, Mannucci PM, Esmon CT, Faioni EM. A 23bp insertion in the endothelial protein C receptor (EPCR) gene in patients with myocardial infarction and deep vein thrombosis. XVIIth Congress of the International Society of Thrombosis and Haemostasis, Washington DC, USA. Thromb Haemost. 1999 Abstracts (Suppl.): 507 (Abstr no 1596).
    PubMedGoogle Scholar
  • 13 Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-4.
    CrossrefPubMedGoogle Scholar
  • 14 Van de Water NS, Williams R, Dare A, Abbott W, Browett PJ. The prevalence of factor V Leiden (Gln506) in Polynesians. Thromb Haemost 1997; 78: 962-3.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 15 Rothbarth K, Dabaghian AR, Stammer H, Werner D. 0ne single mRNA encodes the centrosomal protein CCD41 and the endothelial cell protein C receptor (EPCR). FEBS Letters 1999; 458: 77-80.
    CrossrefPubMedGoogle Scholar