Thromb Haemost 1998; 80(04): 705-706
DOI: 10.1055/s-0037-1615448
Letters to the Editor
Schattauer GmbH

A Polymorphism nt 1628G→A (R485K) in Exon 10 of the Coagulation Factor V Gene May Be a Risk Factor for Thrombosis in the Indigenous Thai Population

Motofumi Hiyoshi
1   From the Department of Laboratory Medicine
,
Pasra Arnutti
1   Departments of Pediatrics, Bangkok, Thailand
,
Wichai Prayoonwiwat
2   Medicine, Bangkok, Thailand
,
Oytip Nathalang
3   Pathology, Pramongkutklao Hospital and College of Medicine, Bangkok, Thailand
,
Chamaiporn Suwanasophon
3   Pathology, Pramongkutklao Hospital and College of Medicine, Bangkok, Thailand
,
Rachapat Kokaseam
2   Medicine, Bangkok, Thailand
,
Shigemi Hashimoto
1   From the Department of Laboratory Medicine
,
Takayuki Takubo
1   From the Department of Laboratory Medicine
,
Shinichi Tagawa
1   From the Department of Laboratory Medicine
,
Mitsuru Fukui
4   Laboratory of Statistics, Osaka City University Medical School, Osaka, Japan
,
Noriyuki Tatsumi
1   From the Department of Laboratory Medicine
› Author Affiliations
Further Information

Publication History

Received 15 April 1998

Accepted after revision 18 June 1998

Publication Date:
08 December 2017 (online)

 

 
  • References

  • 1 Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346: 1133-4.
  • 2 Rees DC. The population genetics of factor V Leiden (Arg506Gln). Br J Haematol 1996; 95: 579-86.
  • 3 Ishida F, Ito T, Ichikawa N, Shimodaira S, Takamiya O, Furihata K, Kiyosawa K, Kitano K. Arg506Gln factor V mutation is uncommon in Eastern Asian populations. Blood 1995; 86: 917a.
  • 4 Sifontes MT, Nuss R, Hunger SP, Wilimas J, Jacobson LJ, Manco-Johnson MJ. The factor V Leiden mutation in children with cancer and thrombosis. Br J Haematol 1997; 96: 484-9.
  • 5 Gandrille S, Greengard JS, Alhenc-Gelas M, Juhan-Vague I, Abgrall JF, Jude B, Griffin JH, Aiach M. the French Network on behalf of INSERM. Incidence of activated protein C resistance caused by the Arg 506 Gln mutation on factor V in 113 unrelated symptomatic protein C deficient patients. Blood 1995; 86: 219-24.
  • 6 Helley D, Besmond C, Ducrocq R, da Silva F, Guillin M-C, Bezeaud A, Elion J. Polymorphism in exon 10 of the human coagulation factor V gene in a population at risk for sickle cell disease. Hum Genet 1997; 100: 245-8.
  • 7 Dahläck B. Resistance to activated protein C as risk factor for thrombosis: molecular mechanisms, laboratory investigation, and clinical management. Semin Hematol 1997; 34: 217-34.