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Thromb Haemost 1999; 81(05): 690-694
DOI: 10.1055/s-0037-1614555
Rapid Communication
Schattauer GmbH

Factor V Leiden, Prothrombin 20210 G → A and the MTHFR C677T Mutations in Childhood Stroke

M. D. McColl
1   From the Royal Hospital for Sick Children, Yorkhill, Glasgow, Scotland, UK
,
E. A. Chalmers
1   From the Royal Hospital for Sick Children, Yorkhill, Glasgow, Scotland, UK
,
A. Thomas
2   Edinburgh Sick Childrens NHS Trust, Scotland, UK
,
A. Sproul
1   From the Royal Hospital for Sick Children, Yorkhill, Glasgow, Scotland, UK
,
C. Healey
2   Edinburgh Sick Childrens NHS Trust, Scotland, UK
,
I. Rafferty
1   From the Royal Hospital for Sick Children, Yorkhill, Glasgow, Scotland, UK
,
R. McWilliam
1   From the Royal Hospital for Sick Children, Yorkhill, Glasgow, Scotland, UK
,
P. Eunson
2   Edinburgh Sick Childrens NHS Trust, Scotland, UK
› Author Affiliations
Further Information

Publication History

Received 23 October 1998

Accepted after resubmission 27 January 1999

Publication Date:
09 December 2017 (online)

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Summary

Ischaemic stroke is a rare occurrence in children and in a proportion of cases the aetiology remains unknown. We have investigated the role of thrombophilia in the aetiology of this condition. Of 50 cases identified at two centres, 37 were available for detailed haematological analysis. No cases were identified with deficiencies of antithrombin, protein C or protein S. One case had elevated IgG anticardiolipin antibodies at low titre. The prevalence of the prothrombin 20210 G→A mutation, factor V Leiden (FVL) mutation and the C677T mutation in the MTHFR gene was compared in cases to that observed in random unselected cord blood controls. The odds ratio for stroke was not significantly increased in carriers of the prothrombin mutation (OR 1.2; 95% CI 0.1-10.7), FVL (OR 2.5; 95% CI 0.5-13.5), or the C677T mutation (OR 1.7; 95% CI 0.6-4.5). Our findings suggest that thrombophilia may not play a significant role in the aetiology of stroke in children, although a large prospective study is required to investigate this area further.

 

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