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Thromb Haemost 1999; 81(04): 582-584
DOI: 10.1055/s-0037-1614528
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Schattauer GmbH

High Prevalence of Factor V Leiden in Healthy Jordanian Arabs

A. Awidi
1   From the Department of Medicine, Faculty of Medicine, Jordan University, Amman, Jordan
,
M. Shannak
1   From the Department of Medicine, Faculty of Medicine, Jordan University, Amman, Jordan
,
A. Bseiso
1   From the Department of Medicine, Faculty of Medicine, Jordan University, Amman, Jordan
,
M. A. M. Kailani
1   From the Department of Medicine, Faculty of Medicine, Jordan University, Amman, Jordan
,
M. A. Kailani
1   From the Department of Medicine, Faculty of Medicine, Jordan University, Amman, Jordan
,
N. Omar
1   From the Department of Medicine, Faculty of Medicine, Jordan University, Amman, Jordan
,
B. Anshasi
1   From the Department of Medicine, Faculty of Medicine, Jordan University, Amman, Jordan
,
N. Sakarneh
1   From the Department of Medicine, Faculty of Medicine, Jordan University, Amman, Jordan
› Author Affiliations
Further Information

Publication History

Received 07 August 1998

Accepted after resubmission 24 November 1998

Publication Date:
09 December 2017 (online)

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Summary

The prevalence of APC resistance in healthy Jordanian Arabs was studied. Between October 1996 through September 1997 a total of 400 healthy subjects were studied. There were 212 males and 188 females. APC resistance was studied by functional and DNA methods. There were a total of 52 subjects (13%) who were APC resistant by the functional test. There were 49 subjects (12.25%) who had FV Q506 by DNA test. Of these there were 42 heterozygous and 7 homozygous (allele frequency 0.07). None of the subjects had clinical thrombosis. It is concluded that the prevalence of APC resistance due to FV Q506 is high in Jordanian Arabs.

 

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