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Thromb Haemost 2000; 84(05): 815-818
DOI: 10.1055/s-0037-1614122
Review Article
Schattauer GmbH

The HR2 Haplotype of Factor V Is not Associated with the Risk of Myocardial Infarction

Carine J. M. Doggen
1   From the Department of Clinical Epidemiology, The Netherlands
,
Marieke C. H. de Visser
2   Hemostasis and Thrombosis Research Center, The Netherlands
,
Hans L. Vos
2   Hemostasis and Thrombosis Research Center, The Netherlands
,
Rogier M. Bertina
2   Hemostasis and Thrombosis Research Center, The Netherlands
,
Volkert Manger Cats
3   Department of Cardiology, Leiden University Medical Center, The Netherlands
,
Frits R. Rosendaal
1   From the Department of Clinical Epidemiology, The Netherlands
2   Hemostasis and Thrombosis Research Center, The Netherlands
› Author AffiliationsThe authors wish to thank the cardiologists of the departments of cardiology, Leiden University Medical Center and the general hospital Diaconessenhuis Leiden and Dr F. J. M. van der Meer, head Leiden Anticoagulant Clinic for their kind cooperation. We thank Mrs T. Visser for drawing blood samples and Mrs P. Noordijk for performing the DNA analysis. For secretarial and administrative support we are indebted to Mrs J. J. Schreijer. We also express our gratitude to all individuals who participated in the “Study of Myocardial Infarctions Leiden”. This research was supported by the Netherlands Heart Foundation (Grant no. 92.345) and the Trombosestichting Nederland (Grant no. 95.001).
Further Information

Publication History

Received 28 February 2000

Accepted after revision 31 May 2000

Publication Date:
13 December 2017 (online)

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Summary

The HR2 haplotype of the factor V gene, which contains the histidine to arginine substitution at position 1299, has been reported to be associated with reduced factor V levels. Because high factor V levels have been found to be associated with an increased risk of myocardial infarction, we examined how the presence of the R2 allele affected the risk of myocardial infarction in the case-control “Study of Myocardial Infarctions Leiden”.

Among 560 men with a first myocardial infarction before the age of 70 years, 9.5% were heterozygous carriers of the R2 allele. The control group consisted of 646 men, in which 9.9% were heterozygous and 0.2% homozygous carriers of the R2 allele. The risk of myocardial infarction in the presence of the R2 allele was not increased (odds ratio, 0.9; 95% confidence interval 0.6 to 1.4). Exclusion of factor V Leiden carriers did not change this result. The risk was 4.4-fold increased for smokers who carried the R2 allele compared to non-smoking noncarriers. No synergy was found between metabolic risk factors and the presence of the R2 allele.

We conclude that the risk of myocardial infarction for men in the presence of the R2 allele of the His1299Arg polymorphism is neither increased nor decreased.

Key words

Factor V - genetic variation - myocardial infarction - risk
 

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