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Thromb Haemost 2000; 83(03): 404-407
DOI: 10.1055/s-0037-1613827
Review Article
Schattauer GmbH

Prospective Analysis after Coronary-artery Bypass Grafting: Platelet GP IIIa Polymorphism (HPA-1b /PlA2) Is a Risk Factor for Bypass Occlusion, Myocardial Infarction, and Death

Rainer B. Zotz
1   From the Department of Haemostasis and Transfusion Medicine, Düsseldorf, Germany
,
Michael Klein
2   Department of Thoracic and Cardiovascular Surgery, Heinrich Heine University Medical Center, Düsseldorf, Germany
,
Hans Peter Dauben
2   Department of Thoracic and Cardiovascular Surgery, Heinrich Heine University Medical Center, Düsseldorf, Germany
,
Christiane Moser
2   Department of Thoracic and Cardiovascular Surgery, Heinrich Heine University Medical Center, Düsseldorf, Germany
,
Emmeran Gams
2   Department of Thoracic and Cardiovascular Surgery, Heinrich Heine University Medical Center, Düsseldorf, Germany
,
Rüdiger E. Scharf
1   From the Department of Haemostasis and Transfusion Medicine, Düsseldorf, Germany
› Author Affiliations
Further Information

Publication History

Received 24 April 1999

Accepted after revision 08 November 1999

Publication Date:
14 December 2017 (online)

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Summary

Recently, we have demonstrated that human platelet antigen 1b (HPA-1b or PlA2) is a hereditary risk factor for platelet thrombogenicity leading to premature myocardial infarction in preexisting coronary artery disease. However, HPA-1b does not represent a risk factor for coronary artery disease itself. The aim of our present study was to evaluate the role of HPA-1b on the outcome in patients after coronaryartery bypass surgery. We prospectively determined the HPA-1 genotype in 261 consecutive patients prior to saphenous-vein coronaryartery bypass grafting. The patients were followed for one year. Among patients with bypass occlusion, myocardial infarction, or death more than 30 days after surgery, the prevalence of HPA-1b was significantly higher than among patients without postoperative complications (60 percent, 6/10, vs. 24 percent, 58/241, p <0.05, odds ratio 4.7). Using a stepwise logistic regression analysis with the variables HPA1b, age, sex, body mass index, smoking (pack-years), hypertension, diabetes, cholesterol and triglyceride concentration, only HPA-1b had a significant association with bypass occlusion, myocardial infarction, or death after bypass surgery (p = 0.019, odds ratio 4.7). This study shows that HPA-1b is a hereditary risk factor for bypass occlusion, myocardial infarction, or death in patients after coronary-artery bypass surgery.

Keywords

Coronary-artery bypass grafting - human platelet antigen 1 (HPA-1) - glycoprotein IIb-IIIa - inherited risk factor
 

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