Correlates of thrombin generation in patients with advanced prostate cancer

Stuart E. Lind; Joseph A. Caprini; Sofia Goldshteyn; James C. Dohnal; Sara K. Vesely; Daniel H. Shevrin

doi:10.1055/s-0037-1613558

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2003; 89(01): 185-189
DOI: 10.1055/s-0037-1613558

Cellular Proteolysis and Oncology

Schattauer GmbH

Correlates of thrombin generation in patients with advanced prostate cancer

Stuart E. Lind

¹The Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma and the Departments of Medicine, Pathology and Surgery, Evanston Northwestern Healthcare and Northwestern University Medical School, Evanston, Illinois, USA

,

Joseph A. Caprini

¹The Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma and the Departments of Medicine, Pathology and Surgery, Evanston Northwestern Healthcare and Northwestern University Medical School, Evanston, Illinois, USA

,

Sofia Goldshteyn

¹The Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma and the Departments of Medicine, Pathology and Surgery, Evanston Northwestern Healthcare and Northwestern University Medical School, Evanston, Illinois, USA

,

James C. Dohnal

¹The Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma and the Departments of Medicine, Pathology and Surgery, Evanston Northwestern Healthcare and Northwestern University Medical School, Evanston, Illinois, USA

,

Sara K. Vesely

¹The Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma and the Departments of Medicine, Pathology and Surgery, Evanston Northwestern Healthcare and Northwestern University Medical School, Evanston, Illinois, USA

,

Daniel H. Shevrin

¹The Departments of Medicine and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma and the Departments of Medicine, Pathology and Surgery, Evanston Northwestern Healthcare and Northwestern University Medical School, Evanston, Illinois, USA

› Author Affiliations

Abstract

Summary

Thrombin generation is increased in men with advanced prostate cancer. Thrombin has the ability to interact with, and affect the biology of, a variety of cell types including prostate cancer cell lines. We therefore looked for correlations between thrombin generation and other markers of disease activity in spot urine samples obtained from men with advanced prostate cancer. Excretion of part of the prothrombin activation peptide F₁₊₂ (called here iF2), interleukin-6 (IL-6), the bone turnover marker deoxypyridinoline (DpD), and vascular endothelial growth factor (VEGF) were quantitated in spot urine samples collected from 37 men with hormone-refractory prostate cancer. Following log transformation of the data, significant correlations were found by univariate analysis between the excretion of a marker of thrombin generation (iF2) and IL-6, DpD and VEGF, as well as between IL-6 and DpD or VEGF excretion. No correlation was found between any marker and serum PSA level. After multivariate analysis, a significant correlation remained between thrombin generation and IL-6 excretion. Analysis of a second urine specimen obtained from 19 of the subjects 1 to 7 months after the first also revealed a significant correlation between thrombin generation and IL-6, DpD, and VEGF excretion. These data provide evidence of a correlation between thrombin generation/coagulation system activation and IL-6 generation in patients with cancer. They provide a rationale for studying the effects of inhibitors of thrombin generation upon the biology of prostate cancer.

Keywords

Coagulation - VEGF - IL-6 - thrombin - cytokines

Full Text

References

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