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DOI: 10.1055/s-0037-1611776
Nucleophilic Trifluoromethylation Reactions Involving Copper(I) Species: From Organometallic Insights to Scope
We thank the CERCA Programme/Generalitat de Catalunya and the Spanish Ministry of Economy, Industry and Competitiveness (MINECO: CTQ2016-79942-P, AIE/FEDER, EU) for the financial support. A. L. M. thanks La Caixa-Severo Ochoa programme for a predoctoral grant.Publication History
Received: 04 February 2019
Accepted after revision: 13 March 2019
Publication Date:
28 March 2019 (online)
![](https://www.thieme-connect.de/media/synthesis/201914/lookinside/thumbnails/ss-2019-z0071-sr_10-1055_s-0037-1611776-1.jpg)
§These authors contributed equally to this work.
Published as part of the Bürgenstock Special Section 2018 Future Stars in Organic Chemistry
Abstract
Over the last decades, trifluoromethyl copper(I) complexes have played a key role as reactive species in C–CF3 bond-forming reactions. This Short Review not only covers selected examples of relevant copper-mediated or catalyzed nucleophilic trifluoromethylation reactions, which is one of the most active fields in organic synthesis, but also provides a comprehensive picture of the real behavior of these copper species, including ubiquitous cuprates, in the reaction media.
1 Introduction
2 Historical Perspective of the Identification of Relevant Trifluoro-
methyl Copper(I) Species
3 In Situ Generation of Active Trifluoromethyl Copper(I) Species
4 Well-Defined Active Trifluoromethyl Copper(I) Complexes
5 Recent Advances on the Performance of Trifluoromethylation
Protocols
6 Conclusions
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For selected recent reviews on trifluoromethylation, see:
For representative examples on the synthesis and reactivity of CuCF3 complexes, see: