Synlett 2019; 30(01): 73-76
DOI: 10.1055/s-0037-1611364
letter
© Georg Thieme Verlag Stuttgart · New York

Cesium Carbonate-Promoted P-Alkylation of Phosphinecarboxamides

Xing-Guo Chen
a   College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, P. R. of China
b   Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials, Lanzhou, 730070, P. R. of China   Email: quanzhengjun@hotmail.com
,
Qiu-Li Wu
a   College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, P. R. of China
b   Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials, Lanzhou, 730070, P. R. of China   Email: quanzhengjun@hotmail.com
,
Fei Hou
a   College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, P. R. of China
b   Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials, Lanzhou, 730070, P. R. of China   Email: quanzhengjun@hotmail.com
,
Xi-Cun Wang
a   College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, P. R. of China
b   Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials, Lanzhou, 730070, P. R. of China   Email: quanzhengjun@hotmail.com
,
Zheng-Jun Quan*
a   College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, P. R. of China
b   Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials, Lanzhou, 730070, P. R. of China   Email: quanzhengjun@hotmail.com
› Author Affiliations
We are thankful for the financial support from the National Nature Science Foundation of China (No 21562036), and the Scientific and Technological Innovation Engineering program of Northwest Normal University (NWNU-LKQN-15-1).
Further Information

Publication History

Received: 09 October 2018

Accepted after revision: 31 October 2018

Publication Date:
03 December 2018 (online)


Abstract

An effective method for the P-alkylation of N-arylphosphinecarboxamides was demonstrated. Primary N-arylphosphinecarboxamides without additional protection underwent P-monoalkylation with various alkyl halides in the presence of cesium carbonate as a promoter. The reactivity of phosphinecarboxamides was also explored.

Supporting Information

 
  • References and Notes

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