Semin Plast Surg 2017; 31(01): 005-016
DOI: 10.1055/s-0037-1598188
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Clinical Evaluation of Blepharoptosis: Distinguishing Age-Related Ptosis from Masquerade Conditions

Michelle W. Latting
1   Wills Eye Hospital, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
,
Alison B. Huggins
1   Wills Eye Hospital, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
,
Douglas P. Marx
4   Division of Oculoplastic and Reconstructive Surgery, Baylor College of Medicine, Houston, Texas
,
Joseph N. Giacometti
2   Department of Oculoplastic and Orbital Surgery, Wills Eye Hospital, Philadelphia, Pennsylvania
3   Morgenstern Center for Orbital and Facial Plastic Surgery, Wayne, Pennsylvania
› Author Affiliations
Further Information

Publication History

Publication Date:
28 February 2017 (online)

Abstract

Aponeurotic ptosis accounts for the majority of acquired ptosis encountered in clinical practice. Other types of ptosis include traumatic, mechanical, neurogenic, and myogenic. In addition to true ptosis, some patients present with pseudoptosis caused by globe dystopia, globe asymmetry, ocular misalignment, or retraction of the contralateral lid. It is particularly important for the clinician to rule out neurologic causes of ptosis such as dysfunction of the third cranial nerve, Horner's syndrome, and myasthenia gravis, as these conditions can be associated with significant systemic morbidity and mortality. A thorough history and physical examination is necessary to evaluate each patient presenting with a complaint of ptosis. Correctly identifying the cause of the patient's complaint allows the ptosis surgeon to plan for appropriate surgical repair when indicated and to defer surgery when observation or additional clinical evaluation is warranted.

 
  • References

  • 1 Jordan D, Mawn L, Anderson RL. Surgical Anatomy of the Ocular Adnexa: A Clinical Approach. New York: Oxford University Press; 2012
  • 2 Lim JM, Hou JH, Singa RM, Aakalu VK, Setabutr P. Relative incidence of blepharoptosis subtypes in an oculoplastics practice at a tertiary care center. Orbit 2013; 32 (4) 231-234
  • 3 Cruz AA, Ribeiro SF, Garcia DM, Akaishi PM, Pinto CT. Graves upper eyelid retraction. Surv Ophthalmol 2013; 58 (1) 63-76
  • 4 Murchison AP, Bilyk JR, Savino PJ. Ptosis in neurologic disease. In: Black EH, et al, eds. Smith and Nesi's Ophthalmic Plastic and Reconstructive Surgery. New York, NY: Springer; 2012: 361-392
  • 5 Bartley GB. The differential diagnosis and classification of eyelid retraction. Ophthalmology 1996; 103 (1) 168-176
  • 6 American Academy of Ophthalmology. Eyelid Retraction. American Academy of Ophthalmology Basic and Clinical Science Course Excerpt. Available at: https://www.aao.org/bcscsnippetdetail.aspx?id=03ad3eb3-3445-4be2-9470-2c4845169b75 . Accessed November 11, 2016
  • 7 Bartley GB. The epidemiologic characteristics and clinical course of ophthalmopathy associated with autoimmune thyroid disease in Olmsted County, Minnesota. Trans Am Ophthalmol Soc 1994; 92: 477-588
  • 8 Bartley GB, Fatourechi V, Kadrmas EF , et al. Clinical features of Graves' ophthalmopathy in an incidence cohort. Am J Ophthalmol 1996; 121 (3) 284-290
  • 9 Bartley GB, Fatourechi V, Kadrmas EF , et al. Chronology of Graves' ophthalmopathy in an incidence cohort. Am J Ophthalmol 1996; 121 (4) 426-434
  • 10 Wiersinga WM, Smit T, van der Gaag R, Koornneef L. Temporal relationship between onset of Graves' ophthalmopathy and onset of thyroidal Graves' disease. J Endocrinol Invest 1988; 11 (8) 615-619
  • 11 Gay AJ, Salmon ML, Windsor CE. Hering's law, the levators, and their relationship in disease states. Arch Ophthalmol 1967; 77 (2) 157-160
  • 12 Cline RA, Rootman J. Enophthalmos: a clinical review. Ophthalmology 1984; 91 (3) 229-237
  • 13 Numa WA, Desai U, Gold DR, Heher KL, Annino DJ. Silent sinus syndrome: a case presentation and comprehensive review of all 84 reported cases. Ann Otol Rhinol Laryngol 2005; 114 (9) 688-694
  • 14 Annino Jr DJ, Goguen LA. Silent sinus syndrome. Curr Opin Otolaryngol Head Neck Surg 2008; 16 (1) 22-25
  • 15 Rose GE, Sandy C, Hallberg L, Moseley I. Clinical and radiologic characteristics of the imploding antrum, or “silent sinus,” syndrome. Ophthalmology 2003; 110 (4) 811-818
  • 16 Arikan OK, Onaran Z, Muluk NB, Yilmazbaş P, Yazici I. Enophthalmos due to atelectasis of the maxillary sinus: silent sinus syndrome. J Craniofac Surg 2009; 20 (6) 2156-2159
  • 17 Buono LM. The silent sinus syndrome: maxillary sinus atelectasis with enophthalmos and hypoglobus. Curr Opin Ophthalmol 2004; 15 (6) 486-489
  • 18 Kinori M, Ko AC, Alameddine RM , et al. Extraocular muscle fibrosis in idiopathic orbital inflammation. J Pediatr Ophthalmol Strabismus 2016; 53 (4) 256 DOI: 10.3928/01913913-20160506-02.
  • 19 Chang BY, Cunniffe G, Hutchinson C. Enophthalmos associated with primary breast carcinoma. Orbit 2002; 21 (4) 307-310
  • 20 Shields CL, Stopyra GA, Marr BP, Moster ML, Shields JA. Enophthalmos as initial manifestation of occult, mammogram-negative carcinoma of the breast. Ophthalmic Surg Lasers Imaging 2004; 35 (1) 56-57
  • 21 Gonçalves AC, Moura FC, Monteiro ML. Bilateral progressive enophthalmos as the presenting sign of metastatic breast carcinoma. Ophthal Plast Reconstr Surg 2005; 21 (4) 311-313
  • 22 Lagrèze WD, Wesendahl TA, Kommerell G. [Enophthalmos caused by orbital metastasis of breast carcinoma]. Klin Monatsbl Augenheilkd 1997; 211 (1) 68-69
  • 23 Hoffmann K, Löblich HJ, Weinrich W. [Enophthalmos with limitation of bulbar motility as a rare clinical symptom of metastasizing carcinoma of the breast (author's transl)]. Klin Monatsbl Augenheilkd 1980; 177 (3) 376-379
  • 24 Lam BL, Thompson HS, Corbett JJ. The prevalence of simple anisocoria. Am J Ophthalmol 1987; 104 (1) 69-73
  • 25 Gross JR, McClelland CM, Lee MS. An approach to anisocoria. Curr Opin Ophthalmol 2016; 27 (6) 486-492
  • 26 Yap EY, Aung T, Fan RF. Pupil abnormalities on the first postoperative day after cataract surgery. Int Ophthalmol 1996-1997–1997; 20 (4) 187-192
  • 27 Brazitikos PD, Roth A. Iris modifications following extracapsular cataract extraction with posterior chamber lens implantation. J Cataract Refract Surg 1991; 17 (3) 269-280
  • 28 Nadeau SE, Trobe JD. Pupil sparing in oculomotor palsy: a brief review. Ann Neurol 1983; 13 (2) 143-148
  • 29 Colon-Acevedo B. Acquired Oculomotor Nerve Palsy. Available at: http://eyewiki.aao.org/Acquired_Oculomotor_Nerve_Palsy#cite_note-:1-2 Accessed November 11, 2016
  • 30 Vaphiades MS, Cure J, Kline L. Management of intracranial aneurysm causing a third cranial nerve palsy: MRA, CTA or DSA?. Semin Ophthalmol 2008; 23 (3) 143-150
  • 31 Chaudhary N, Davagnanam I, Ansari SA, Pandey A, Thompson BG, Gemmete JJ. Imaging of intracranial aneurysms causing isolated third cranial nerve palsy. J Neuroophthalmol 2009; 29 (3) 238-244
  • 32 Lee AG, Hayman LA, Brazis PW. The evaluation of isolated third nerve palsy revisited: an update on the evolving role of magnetic resonance, computed tomography, and catheter angiography. Surv Ophthalmol 2002; 47 (2) 137-157
  • 33 Trobe JD. Isolated third nerve palsies. Semin Neurol 1986; 6 (2) 135-141
  • 34 Trobe JD. Isolated pupil-sparing third nerve palsy. Ophthalmology 1985; 92 (1) 58-61
  • 35 Trobe JD. Third nerve palsy and the pupil. Footnotes to the rule. Arch Ophthalmol 1988; 106 (5) 601-602
  • 36 Walton KA, Buono LM. Horner syndrome. Curr Opin Ophthalmol 2003; 14 (6) 357-363
  • 37 Mughal M, Longmuir R. Current pharmacologic testing for Horner syndrome. Curr Neurol Neurosci Rep 2009; 9 (5) 384-389
  • 38 Mahoney NR, Liu GT, Menacker SJ, Wilson MC, Hogarty MD, Maris JM. Pediatric Horner syndrome: etiologies and roles of imaging and urine studies to detect neuroblastoma and other responsible mass lesions. Am J Ophthalmol 2006; 142 (4) 651-659
  • 39 Jeffery AR, Ellis FJ, Repka MX, Buncic JR. Pediatric Horner syndrome. J AAPOS 1998; 2 (3) 159-167
  • 40 Imesch PD, Wallow IH, Albert DM. The color of the human eye: a review of morphologic correlates and of some conditions that affect iridial pigmentation. Surv Ophthalmol 1997; 41 (Suppl. 02) S117-S123
  • 41 Gladstone RM. Development and significance of heterochromia of the iris. Arch Neurol 1969; 21 (2) 184-191
  • 42 Almog Y, Gepstein R, Kesler A. Diagnostic value of imaging in Horner syndrome in adults. J Neuroophthalmol 2010; 30 (1) 7-11
  • 43 Flaherty PM, Flynn JM. Horner syndrome due to carotid dissection. J Emerg Med 2011; 41 (1) 43-46
  • 44 Lepore FE. Enophthalmos and Horner's syndrome. Arch Neurol 1983; 40 (7) 460 DOI: 10.1001/archneur.1983.04050070090034.
  • 45 Danesh-Meyer HV, Savino P, Sergott R. The correlation of phenylephrine 1% with hydroxyamphetamine 1% in Horner's syndrome. Br J Ophthalmol 2004; 88 (4) 592-593
  • 46 Falzon K, Jungkim S, Charalampidou S, Townley D, Flitcroft DI. Denervation supersensitivity to 1% phenylephrine in Horner syndrome can be demonstrated 10 days after the onset of symptoms. Br J Ophthalmol 2009; 93 (1) 130 DOI: 10.1136/bjo.2008.143487.
  • 47 Morales J, Brown SM, Abdul-Rahim AS, Crosson CE. Ocular effects of apraclonidine in Horner syndrome. Arch Ophthalmol 2000; 118 (7) 951-954
  • 48 Koc F, Kavuncu S, Kansu T, Acaroglu G, Firat E. The sensitivity and specificity of 0.5% apraclonidine in the diagnosis of oculosympathetic paresis. Br J Ophthalmol 2005; 89 (11) 1442-1444
  • 49 Freedman KA, Brown SM. Topical apraclonidine in the diagnosis of suspected Horner syndrome. J Neuroophthalmol 2005; 25 (2) 83-85
  • 50 Watts P, Satterfield D, Lim MK. Adverse effects of apraclonidine used in the diagnosis of Horner syndrome in infants. J AAPOS 2007; 11 (3) 282-283
  • 51 Trobe JD. The evaluation of Horner syndrome. J Neuroophthalmol 2010; 30 (1) 1-2
  • 52 Biousse V, Touboul PJ, D'Anglejan-Chatillon J, Lévy C, Schaison M, Bousser MG. Ophthalmologic manifestations of internal carotid artery dissection. Am J Ophthalmol 1998; 126 (4) 565-577
  • 53 Glatt HJ, Putterman AM, Fett DR. Muller's muscle-conjunctival resection procedure in the treatment of ptosis in Horner's syndrome. Ophthalmic Surg 1990; 21 (2) 93-96
  • 54 Levinson AI, Zweiman B, Lisak RP. Immunopathogenesis and treatment of myasthenia gravis. J Clin Immunol 1987; 7 (3) 187-197
  • 55 Appel SH, Elias SB, Chauvin P. The role of acetylcholine receptor antibodies in myasthenia gravis. Fed Proc 1979; 38 (10) 2381-2385
  • 56 Lennon VA. The immunopathology of myasthenia gravis. Hum Pathol 1978; 9 (5) 541-551
  • 57 Grob D, Brunner N, Namba T, Pagala M. Lifetime course of myasthenia gravis. Muscle Nerve 2008; 37 (2) 141-149
  • 58 Vincent A, Clover L, Buckley C, Grimley Evans J, Rothwell PM ; UK Myasthenia Gravis Survey. Evidence of underdiagnosis of myasthenia gravis in older people. J Neurol Neurosurg Psychiatry 2003; 74 (8) 1105-1108
  • 59 Libman R, Benson R, Einberg K. Myasthenia mimicking vertebrobasilar stroke. J Neurol 2002; 249 (11) 1512-1514
  • 60 Sharp HR, Degrip A, Mitchell DB, Heller A. Bulbar presentations of myasthenia gravis in the elderly patient. J Laryngol Otol 2001; 115 (1) 1-3
  • 61 Berrouschot J, Baumann I, Kalischewski P, Sterker M, Schneider D. Therapy of myasthenic crisis. Crit Care Med 1997; 25 (7) 1228-1235
  • 62 Golnik KC, Pena R, Lee AG, Eggenberger ER. An ice test for the diagnosis of myasthenia gravis. Ophthalmology 1999; 106 (7) 1282-1286
  • 63 Vincent A, Newsom-Davis J. Acetylcholine receptor antibody as a diagnostic test for myasthenia gravis: results in 153 validated cases and 2967 diagnostic assays. J Neurol Neurosurg Psychiatry 1985; 48 (12) 1246-1252
  • 64 Lindstrom JM, Seybold ME, Lennon VA, Whittingham S, Duane DD. Antibody to acetylcholine receptor in myasthenia gravis. Prevalence, clinical correlates, and diagnostic value. Neurology 1976; 26 (11) 1054-1059
  • 65 Hoch W, McConville J, Helms S, Newsom-Davis J, Melms A, Vincent A. Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies. Nat Med 2001; 7 (3) 365-368
  • 66 Muppidi S, Wolfe GI. Muscle-specific receptor tyrosine kinase antibody-positive and seronegative myasthenia gravis. Front Neurol Neurosci 2009; 26: 109-119
  • 67 Sanders DB, El-Salem K, Massey JM, McConville J, Vincent A. Clinical aspects of MuSK antibody positive seronegative MG. Neurology 2003; 60 (12) 1978-1980
  • 68 Padua L, Stalberg E, LoMonaco M, Evoli A, Batocchi A, Tonali P. SFEMG in ocular myasthenia gravis diagnosis. Clin Neurophysiol 2000; 111 (7) 1203-1207
  • 69 Spillane J, Higham E, Kullmann DM. Myasthenia gravis. BMJ 2012; 345: e8497 DOI: 10.1136/bmj.e8497.
  • 70 Frueh BR. Graves' eye disease: orbital compliance and other physical measurements. Trans Am Ophthalmol Soc 1984; 82: 492-598
  • 71 Murchison AP, Sires BA, Jian-Amadi A. Margin reflex distance in different ethnic groups. Arch Facial Plast Surg 2009; 11 (5) 303-305
  • 72 Beard C. The surgical treatment of blepharoptosis: a quantitative approach. Trans Am Ophthalmol Soc 1966; 64: 401-487
  • 73 Putterman AM, Urist MJ. Müller muscle-conjunctiva resection. Technique for treatment of blepharoptosis. Arch Ophthalmol 1975; 93 (8) 619-623
  • 74 Weinstein GS, Buerger Jr GF. Modification of the Müller's muscle-conjunctival resection operation for blepharoptosis. Am J Ophthalmol 1982; 93 (5) 647-651
  • 75 Dresner SC. Further modifications of the Müller's muscle-conjunctival resection procedure for blepharoptosis. Ophthal Plast Reconstr Surg 1991; 7 (2) 114-122
  • 76 Mazow ML, Shulkin ZA. Mueller's muscle-conjunctival resection in the treatment of congenital ptosis. Ophthal Plast Reconstr Surg 2011; 27 (5) 311-312
  • 77 Jordan DR, Anderson RL. The aponeurotic approach to congenital ptosis. Ophthalmic Surg 1990; 21 (4) 237-244
  • 78 Skaat A, Fabian D, Spierer A, Rosen N, Rosner M, Ben Simon GJ. Congenital ptosis repair-surgical, cosmetic, and functional outcome: a report of 162 cases. Can J Ophthalmol 2013; 48 (2) 93-98
  • 79 Dutton JJ. Surgical management of floppy eyelid syndrome. Am J Ophthalmol 1985; 99 (5) 557-560
  • 80 Valenzuela AA, Sullivan TJ. Medial upper eyelid shortening to correct medial eyelid laxity in floppy eyelid syndrome: a new surgical approach. Ophthal Plast Reconstr Surg 2005; 21 (4) 259-263
  • 81 Mills DM, Meyer DR, Harrison AR. Floppy eyelid syndrome: quantifying the effect of horizontal tightening on upper eyelid position. Ophthalmology 2007; 114 (10) 1932-1936