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J Pediatr Infect Dis 2017; 12(02): 138-141
DOI: 10.1055/s-0037-1598182
Case Report
Georg Thieme Verlag KG Stuttgart · New York

Neonatal Meningitis Caused by Actinomyces: A Case Report of the Most Probably New Strain

Mehmet Sah İpek
1   Division of Neonatology, Department of Pediatrics, Diyarbakir Maternity and Children Hospital, Diyarbakir, Turkey
,
Erdal Ozbek
2   Department of Microbiology, Diyarbakir Maternity and Children Hospital, Diyarbakir, Turkey
,
Dilek Guldemir
3   Department of Microbiology Reference Laboratories, National Reference Laboratory for Molecular Microbiology, Public Health Institution of Turkey, Ankara, Turkey
,
Nezahat Akpolat
4   Department of Microbiology, Dicle University Faculty of Medicine, Diyarbakir, Turkey
› Author Affiliations
Further Information

Publication History

06 October 2016

20 December 2016

Publication Date:
10 February 2017 (online)

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Abstract

Over the past three decades, the detection and identification of the Actinomyces spp. in clinical microbiology laboratories, in addition to their recognition as pathogens in clinical settings, have proven challenging. A case of a preterm neonate who was diagnosed with meningitis caused by the Actinomyces spp. during application of a ventricular puncture for the treatment of posthemorrhagic hydrocephalus was presented. PCR tests showed that the neonate's strain exhibited 98.26% 16S ribosomal ribonucleic acid (rRNA) gene sequence similarity with the Actinomyces oris strain (ATCC 27044). The GenBank accession number for the nucleotide sequence is Actinomyces KX026867. This case report provides evidence that the Actinomyces spp. should be considered as a potential pathogen of neonatal meningitis, even if the strain is rarely isolated, phenotypically aberrant, and has often been poorly described.

Keywords

Actinomyces - neonate - infection - 16S rRNA gene sequence - case report
 

  • References

  • 1 Könönen E, Wade WG. Actinomyces and related organisms in human infections. Clin Microbiol Rev 2015; 28 (2) 419-442
    CrossrefPubMedGoogle Scholar
  • 2 Seng P, Drancourt M, Gouriet F , et al. Ongoing revolution in bacteriology: routine identification of bacteria by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Clin Infect Dis 2009; 49 (4) 543-551
    CrossrefPubMedGoogle Scholar
  • 3 Clarridge III JE. Impact of 16S rRNA gene sequence analysis for identification of bacteria on clinical microbiology and infectious diseases. Clin Microbiol Rev 2004; 17 (4) 840-862
    CrossrefPubMedGoogle Scholar
  • 4 Abadi MA, Abadi J. Actinomyces chorioamnionitis and preterm labor in a twin pregnancy: a case report. Am J Obstet Gynecol 1996; 175 (5) 1391-1392
    CrossrefPubMedGoogle Scholar
  • 5 Zakut H, Achiron R, Treschan O, Kutin E. Actinomyces invasion of placenta as a possible cause of preterm delivery. Clin Exp Obstet Gynecol 1987; 14 (2) 89-91
    PubMedGoogle Scholar
  • 6 Mann C, Dertinger S, Hartmann G, Schurz R, Simma B. Actinomyces neuii and neonatal sepsis. Infection 2002; 30 (3) 178-180
    CrossrefPubMedGoogle Scholar
  • 7 Knee DS, Christ MJ, Gries DM, Thompson MW. Actinomyces species and cerclage placement in neonatal sepsis: a case report. J Perinatol 2004; 24 (6) 389-391
    CrossrefPubMedGoogle Scholar
  • 8 Fitzhugh VA, Pompeo L, Heller DS. Placental invasion by Actinomyces resulting in preterm delivery: a case report. J Reprod Med 2008; 53 (4) 302-304
    PubMedGoogle Scholar
  • 9 Smego Jr RA. Actinomycosis of the central nervous system. Rev Infect Dis 1987; 9 (5) 855-865
    CrossrefPubMedGoogle Scholar
  • 10 Sarkonen N, Könönen E, Summanen P, Kanervo A, Takala A, Jousimies-Somer H. Oral colonization with Actinomyces species in infants by two years of age. J Dent Res 2000; 79 (3) 864-867
    CrossrefPubMedGoogle Scholar
  • 11 Moore WE, Moore LV. The bacteria of periodontal diseases. Periodontol 2000 1994; 5: 66-77
    CrossrefPubMedGoogle Scholar
  • 12 Kommedal Ø, Wilhelmsen MT, Skrede S , et al. Massive parallel sequencing provides new perspectives on bacterial brain abscesses. J Clin Microbiol 2014; 52 (6) 1990-1997
    CrossrefPubMedGoogle Scholar
  • 13 Anderson IA, Jarral F, Sethi K, Chumas PD. Paediatric ventriculo peritoneal shunt infection caused by Actinomyces neuii. . BMJ Case Rep 2014; DOI: 10.1136/bcr-2014–204576.
    PubMedGoogle Scholar
  • 14 Henssge U, Do T, Radford DR, Gilbert SC, Clark D, Beighton D. Emended description of Actinomyces naeslundii and descriptions of Actinomyces oris sp. nov. and Actinomyces johnsonii sp. nov., previously identified as Actinomyces naeslundii genospecies 1, 2 and WVA 963. Int J Syst Evol Microbiol 2009; 59 (Pt 3): 509-516
    CrossrefPubMedGoogle Scholar