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DOI: 10.1055/s-0036-1597650
Serotype Distribution and Antimicrobial Resistance of Invasive S. pneumoniae among Indian Children before the Introduction of Pneumococcal Conjugate Vaccine
Publication History
30 October 2016
21 November 2016
Publication Date:
15 December 2016 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00029028/201604/lookinside/thumbnails/10-1055-s-0036-1597650_1600039-1.jpg)
Abstract
This study was conducted to provide current information on serotype distribution and drug resistance patterns of invasive Streptococcus pneumoniae among children. Sterile site samples from 1,504 children ≤5 years, who were clinically and radiologically suspected of having invasive pneumococcal infection were evaluated. The leading serotypes causing invasive pneumococcal disease (IPD) were 1, 6B, and 14. High-level penicillin resistance was observed in 11% of isolates belonging to serotypes 6B, 1, and 5. Multidrug resistance was observed in 24% of strains. Our results reveal that PCV-10 and PCV-13 vaccines can protect against 68% and 78% of IPD serotypes, respectively.
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