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Journal of Pediatric Biochemistry 2016; 06(03): 152-155
DOI: 10.1055/s-0036-1597607
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Association of Thiol Disulfide Homeostasis with Childhood Asthma

Buket Kubra Kaya
1   Department of Biochemistry, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey
,
Murat Aydin
1   Department of Biochemistry, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey
,
Mustafa Metin Donma
2   Department of Pediatrics, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey
,
Muhammet Demirkol
2   Department of Pediatrics, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey
,
Cemile Bicer
3   Department of Biochemistry, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey
,
Ozcan Erel
3   Department of Biochemistry, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey
› Author Affiliations
Further Information

Publication History

29 March 2016

11 November 2016

Publication Date:
20 December 2016 (online)

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Abstract

The aim of this study is to evaluate the oxidative stress level in asthmatic children in terms of the disulfide/thiol ratio, to research the role the disulfide/thiol ratio plays in the pathogenesis of the malady, and to determine the usefulness of the disulfide/thiol ratio as an indicator of the oxidation stress situations in patients with asthma. We report that the disulfide/thiol ratio and disulfide levels were significantly higher in the asthmatic group than in the control group. All in all, high levels of disulfide/thiol ratios in asthmatic children are thought to play roles in the pathogenesis of the disease.

Keywords

thiol - disulfide - disulfide/thiol ratio - pathogenesis - asthma - oxidative stress
 

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