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DOI: 10.1055/s-0036-1591948
Nucleophilic 18F-Fluorination of Anilines via N-Arylsydnone Intermediates
This research was supported by the Jonsson Comprehensive Cancer Center, the Crump Institute for Molecular Imaging, the NIH (R01GM109078) and the FRQNT (post-doctoral fellowship to P.A.C.).Publication History
Received: 11 January 2018
Accepted after revision: 08 February 2018
Publication Date:
26 February 2018 (online)
Abstract
Preparation of [18F]fluoroarenes with nucleophilic [18F]fluoride for positron emission tomography (PET) molecular imaging research is a challenging chemical endeavor. Advances in radiofluorination have soared in the last decade, broadening the availability of potential [18F]fluoroarenes. In this Synpacts article, we highlight the recent development from our laboratory of a practical radiofluorination of anilines via N-arylsydnone intermediates to afford [18F]fluoroarenes. Further, we emphasize the utility of this methodology towards peptide labeling applications by preparing an 18F-labeled neuropeptide.
1 Introduction
2 Nucleophilic Radiofluorination of N-Arylsydnones
3 Substrate Scope and Applications
4 Conclusion
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