Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2017; 13(11): 1155
DOI: 10.1055/s-0036-1591388
DOI: 10.1055/s-0036-1591388
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
Copper-Catalyzed Hydroarylation Reaction
Further Information
Publication History
Publication Date:
19 October 2017 (online)
Significance
The stereoselective synthesis of trisubstituted olefins has attracted considerable attention due to the prevalence of such structural motifs in pharmaceuticals and as valuable synthetic building blocks. In this paper, the authors present a stereoselective copper-catalyzed hydroarylation of internal alkynes for the synthesis of 1,1-diaryl trisubstituted olefins.
#
Comment
The combination of a copper(II) catalyst, polymethylhydrosiloxane as hydride source, and additives allowed the reaction between internal alkynes and several aryl iodides. The corresponding products were generally obtained in good to excellent yields and with high regioselectivities. Several 2.0 mmol scale reactions were demonstrated.
#
#