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Semin Reprod Med 2015; 33(06): 396-400
DOI: 10.1055/s-0035-1567822
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Metabolic Determinants of Mitochondrial Function in Oocytes

Emily A. Seidler
1   Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri
,
Kelle H. Moley
1   Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri
› Author Affiliations
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Publication History

Publication Date:
12 November 2015 (online)

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Abstract

Mitochondrial production of cellular energy is essential to oocyte function, zygote development and successful continuation of pregnancy. This review focuses on several key functions of healthy oocyte mitochondria and the effect of pathologic states such as aging, oxidative stress and apoptosis on these functions. The effect of these abnormal conditions is presented in terms of clinical presentations, specifically maternal obesity, diminished ovarian reserve and assisted reproductive technologies.

Keywords

oocyte metabolism - oocyte quality - mitochondrial transplant - reactive oxygen species - mitochondrial DNA - mitochondrial function
 

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