Synlett 2016; 27(12): 1860-1863
DOI: 10.1055/s-0035-1561986
letter
© Georg Thieme Verlag Stuttgart · New York

Metal-Free tert-Butyl Hydrogenperoxide (TBHP) Mediated Radical Alkylation of Enol Acetates with Alcohols: A New Route to β-Hydroxy Ketones

Yucai Tang
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. of China   eMail: xqli@zjut.edu.cn   eMail: future@zjut.edu.cn
,
Yuanyuan Fan
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. of China   eMail: xqli@zjut.edu.cn   eMail: future@zjut.edu.cn
,
Ye Zhang
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. of China   eMail: xqli@zjut.edu.cn   eMail: future@zjut.edu.cn
,
Xiaoqing Li*
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. of China   eMail: xqli@zjut.edu.cn   eMail: future@zjut.edu.cn
,
Xiangsheng Xu*
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. of China   eMail: xqli@zjut.edu.cn   eMail: future@zjut.edu.cn
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Publikationsverlauf

Received: 30. Januar 2016

Accepted after revision: 14. März 2016

Publikationsdatum:
21. April 2016 (online)


Abstract

A metal-free TBHP-mediated radical alkylation of enol acetates with alcohols is described. This method provides a new route to a variety of β-hydroxy-ketones in moderate to good yields.

Supporting Information