Synthesis 2016; 48(23): 4161-4166
DOI: 10.1055/s-0035-1561493
paper
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Typical Isocopalane Diterpenes: ent-Spongian-16-one, ent-Isoagatholactone, and Anisodorin 5

Jiangmeng Ren
a   School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. of China
,
Pu Zhao
a   School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. of China
,
Xiong Xiao
a   School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. of China
,
Tianqi Chen
a   School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. of China
,
Bu-Bing Zeng*
a   School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. of China
b   Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200232, P. R. of China   Email: zengbb@ecust.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 09 May 2016

Accepted after revision: 06 June 2016

Publication Date:
17 August 2016 (online)


Abstract

A synthetic approach to the isocopalane diterpenes ent-spongian-16-one, ent-isoagatholactone, and anisodorin 5 is presented. ent-Spongian-16-one was prepared by using a tricyclic diterpene building block as the starting material. Furthermore, ent-spongian-16-one was easily converted into ent-isoagatholactone and anisodorin 5 through organic transformations.

Supporting Information

 
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