Synlett 2015; 26(18): 2485-2490
DOI: 10.1055/s-0035-1560635
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© Georg Thieme Verlag Stuttgart · New York

The Biosynthesis and Biomimetic Synthesis of Merochlorins A and B

Henry P. Pepper
Department of Chemistry, University of Adelaide, Adelaide, SA 5005, Australia   Email: jonathan.george@adelaide.edu.au
,
Jonathan H. George*
Department of Chemistry, University of Adelaide, Adelaide, SA 5005, Australia   Email: jonathan.george@adelaide.edu.au
› Author Affiliations
Further Information

Publication History

Received: 27 July 2015

Accepted after revision: 04 September 2015

Publication Date:
30 September 2015 (online)


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Abstract

The interplay between biosynthetic studies and biomimetic synthesis is discussed in the context of the merochlorin family of marine natural products. Total syntheses of merochlorin A by our group and merochlorin B by the Trauner group are presented alongside the biosynthetic studies of Moore and co-workers. The common theme is the generation of complex polycyclic ring systems by oxidative dearomatization–cyclization cascade reactions.