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Synlett 2015; 26(18): 2598-2600
DOI: 10.1055/s-0035-1560634
DOI: 10.1055/s-0035-1560634
letter
One-Pot Synthesis of Isoquinolin-1(2H)-ones by a Sequential Ugi 4CC/Wittig Process
Weitere Informationen
Publikationsverlauf
Received: 13. Juli 2015
Accepted after revision: 27. August 2015
Publikationsdatum:
23. September 2015 (online)


Abstract
A one-pot synthetic approach to isoquinolin-1(2H)-ones through a Ugi/Wittig sequence has been developed. The reaction of phosphonium salt, aldehyde, secondary amine, and isocyanide produced isoquinolin-1(2H)-ones in good yields through sequential Ugi condensation and intramolecular Wittig reaction in the presence of K2CO3.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560634.
- Supporting Information