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Synlett 2016; 27(03): 417-421
DOI: 10.1055/s-0035-1560365
letter
© Georg Thieme Verlag Stuttgart · New York

An Efficient Synthesis of 2,4,6-Triarylpyridines by Use of Benzyl Halides under Neat Conditions

Mehdi Adib*
a   School of Chemistry, College of Science, University of Tehran, P. O. Box 14155-6455 Tehran, Iran   Email: madib@khayam.ut.ac.ir
,
Neda Ayashi
a   School of Chemistry, College of Science, University of Tehran, P. O. Box 14155-6455 Tehran, Iran   Email: madib@khayam.ut.ac.ir
,
Peiman Mirzaei
b   Department of Chemistry, Shahid Beheshti University, Tehran, Iran
› Author Affiliations
Further Information

Publication History

Received: 14 August 2015

Accepted after revision: 04 October 2015

Publication Date:
24 November 2015 (online)

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Abstract

An efficient synthesis of 2,4,6-triarylpyridines is described. Heating a mixture of an acetophenone, a benzyl halide, and ammonium acetate under neat conditions afforded the corresponding Kröhnke pyridines in excellent yields.

Key words

2,4,6-triarylpyridines - Kröhnke pyridines - acetophenones - benzyl halides - heterocycles - cyclizations
 

  • References and Notes

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