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Synfacts 2015; 11(10): 1105
DOI: 10.1055/s-0035-1560273
DOI: 10.1055/s-0035-1560273
Polymer-Supported Synthesis
Asymmetric Carbonyl Reduction with a Supported Ketoreductase
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
18. September 2015 (online)
![](https://www.thieme-connect.de/media/synfacts/201510/i_y109_s1_10-1055_s-0035-1560273.gif)
Significance
Immobilized ketoreductase P1B2 (immob P1B2), prepared as shown in eq. 1, catalyzed the asymmetric transfer-hydrogenation of ketones in 90:10 propan-2-ol–water to give the corresponding alcohols in up to 100% conversion and up to >99% ee (eq. 2). This reaction was used in a 50 g scale reduction of 3,5-[bis(trifluoromethyl)phenyl]ethanone (1) (eq. 3).
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Comment
Immob P1B2 was recovered and reused nine times without any loss of its catalytic performance. The catalyst was also used in a flow transfer hydrogenation of ketone 1.
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![](https://www.thieme-connect.de/media/synfacts/201510/i_y109_s1_10-1055_s-0035-1560273.gif)