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Semin Liver Dis 2015; 35(02): 097-106
DOI: 10.1055/s-0035-1550061
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Origin and Function of Myofibroblasts in the Liver

Rebecca G. Wells
1   Departments of Medicine (GI) and Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
,
Robert F. Schwabe
2   Department of Medicine, Columbia University, New York, New York
3   Institute of Human Nutrition, Columbia University, New York, New York
› Author Affiliations
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Publication History

Publication Date:
14 May 2015 (online)

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Origin and Function of Myofibroblasts in the LiverSemin Liver Dis 2015; 35(02): e1-e1
DOI: 10.1055/s-0035-1554915

Abstract

Liver fibrosis contributes to many of the devastating complications of viral, toxic, fatty, and cholestatic liver disease. Understanding the cell populations that promote liver fibrosis and the molecular pathways through which they operate is essential for the development of antifibrotic therapies. The authors review the origins and functions of hepatic myofibroblasts, focusing on hepatic stellate cells, the main contributors to organ fibrosis, and portal fibroblasts, an insufficiently characterized population that may have a specialized function in promoting periductular fibrosis, but a limited role in overall organ fibrosis. They discuss the hypothesis that each fibrogenic cell population in the liver exerts specific functions, and whether cell type-specific antifibrotic strategies are required or whether one therapeutic strategy fits all.

Keywords

hepatic stellate cell - portal fibroblast - fibrocyte
 

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