Download PDF
Der Nuklearmediziner 2014; 37(04): 213-218
DOI: 10.1055/s-0034-1387749
Pädiatrische Nuklearmedizin
© Georg Thieme Verlag KG Stuttgart · New York

Diagnostik von benignen und malignen Erkrankungen mit Knochenbeteiligung im Kindes- und Jugendalter mittels Knochenszintigrafie – ein Update

The Role of Bone Scintigraphy in Non-neoplastic and Neoplastic Diseases in Children and Adolescents – An Update
P. Genseke
1   Klinik für Radiologie und Nuklearmedizin, Universitätsklinikum Magdeburg A.ö.R., Otto-von-Guericke-Universität
,
C. Furth
1   Klinik für Radiologie und Nuklearmedizin, Universitätsklinikum Magdeburg A.ö.R., Otto-von-Guericke-Universität
,
R. Kluge
2   Klinik für Nuklearmedizin, Universitätsklinikum Leipzig A.ö.R.
,
T. Pfluger
3   Klinik für Nuklearmedizin, LMU München
,
C. Franzius
4   Zentrum für Nuklearmedizin und PET/CT; Zentrum für morphologische und molekulare Diagnostik (ZeMoDi), Bremen
,
J. Ruf
5   Klinik für Nuklearmedizin, Universitätsklinikum Freiburg
,
M. Weckesser
6   Klinik und Poliklinik für Nuklearmedizin, Universitätsklinikum Münster
,
H. Amthauer
1   Klinik für Radiologie und Nuklearmedizin, Universitätsklinikum Magdeburg A.ö.R., Otto-von-Guericke-Universität
› Author Affiliations
Further Information

Publication History

Publication Date:
24 November 2014 (online)

Also available at
    Permissions and Reprints

Zusammenfassung

Knocheneigene maligne Tumoren, Tumoren mit sekundärer Knochenbeteiligung sowie benigne Knochenerkrankungen im Kindes- und Jugendalter stellen den behandelnden Arzt oftmals vor große Herausforderungen hinsichtlich des weiteren Vorgehens. Dieser Artikel adressiert die Knochenszintigrafie als integralen Bestandteil der Diagnostik o.g. Erkrankungen. Neben Indikationen werden altersspezifisch vorbereitende Maßnahmen und angepasste Untersuchungsdurchführungen, Befundinterpretation sowie die Strahlenexposition dargestellt. Hierbei wird sowohl auf die planare Szintigrafie als auch auf räumlich aufgelöste Verfahren wie die SPECT bzw. SPECT/CT eingegangen.

Abstract

In pediatric and adolescent patients, primary bone tumors as well as metastatic bone disease or benign bone affections are often challenging to physicians concerning the further therapeutical work-up. This article focusses on radioisotope bone scan which represents a substantial part of the diagnostic work-up. Among indications age specific preparations and examinations as well as interpretation and radiation exposure will be discussed. Besides planar radioisotope bone scan-imaging the use of SPECT and SPECT/CT are presented.

Schlüsselwörter

Knochenszintigrafie - Kinder - Jugendliche - Strahlenexposition - SPECT - SPECT/CT

Key words

bone scintigraphy - paediatrics - adolescents - radiation exposure - SPECT - SPECT/CT
 

  • Literatur

  • 1 Allwright S, Miller J, Gilsanz V. Subperiosteal abscess in children: Scintigraphic appearance. Radiology 1991; 179: 725-729
    CrossrefPubMedGoogle Scholar
  • 2 Balingit A, Rudd S, Williams S. Clinical utility of bone SPECT scintigraphy in renal metastases from primary osteosarcoma. Clin Nucl Med 1994; 19: 1098-1101
    CrossrefPubMedGoogle Scholar
  • 3 Bongers H, Loup E, Reuland P et al. Radiological and scintigraphic features of primary chronic osteomyelitis. Fortschr Roentgenstr 1988; 149: 136-142
    Article in Thieme ConnectPubMedGoogle Scholar
  • 4 Conway JJ, Collins M, Tanz RR et al. The role of bone scintigraphy in detecting child abuse. Semin Nucl Med 1993; 23: 321-333
    CrossrefPubMedGoogle Scholar
  • 5 Dogan AS, Conway JJ, Miller JH et al. Detection of bone lesions in Langerhans cell histiocytosis: Complementary roles of scintigraphy and conventional radiography. J Pediatr Hematol Oncol 1996; 18: 51-58
    CrossrefPubMedGoogle Scholar
  • 6 El-Shanti HI, Ferguson PJ. Chronic recurrent multifocal osteomyelitis: a concise review and genetic update. Clin Orthop Relat Res 2007; 462: 11-19
    CrossrefPubMedGoogle Scholar
  • 7 Gilday D. Problems in scintigraphic detection of osteomyelitis. Radiology 1980; 135: 791
    CrossrefPubMedGoogle Scholar
  • 8 Gilday D, Paul D, Paterson J. Diagnosis of osteomyelitis in children by combined blood pool and bone imaging. Radiology 1975; 117: 331-335
    CrossrefPubMedGoogle Scholar
  • 9 Gordon L, Hahn K, Fischer S. Atlas of bone scintigraphy in the pathological paediatric skeleton. Berlin: Springer Verlag; 1996
    CrossrefGoogle Scholar
  • 10 Gordon L, Peters A, Nunn R. The symptomatic hip in childhood: Scintigraphic findings in the presence of a normal radiograph. Skeletal Radiol 1987; 16: 383-386
    CrossrefPubMedGoogle Scholar
  • 11 Grant FD, Fahey FH, Packard AB et al. Skeletal PET with 18F-fluoride: applying new technology to an old tracer. J Nucl Med 2008; 49: 68-78
    PubMedGoogle Scholar
  • 12 Handmaker H, Leonards R. The bone scan in inflammatory osseous disease. Semin Nucl Med 1976; 6: 95-105
    CrossrefPubMedGoogle Scholar
  • 13 Howmann-Gilles R, Uren R. Multifocal OM in childhood: Review by radionuclide bone scan. Clin Nucl Med 1992; 17: 274-278
    CrossrefPubMedGoogle Scholar
  • 14 Hughes L, Aronson J. Skeletal infections in children. Curr Opin Pediatr 1994; 6: 90-93
    CrossrefPubMedGoogle Scholar
  • 15 Itoh K, Hashimoto T, Shigenobu K et al. Bone SPECT of symptomatic lumbar spondylosis. Nucl Med Commun 1996; 17: 389-396
    CrossrefPubMedGoogle Scholar
  • 16 Jurriaans E, Singh NP, Finlay K et al. Imaging of chronic recurrent multifocal osteomyelitis. Radiol Clin North Am 2001; 39: 305-327
    CrossrefPubMedGoogle Scholar
  • 17 Kaniklides C, Sahlstedt B, Lönnerholm T et al. Conventional radiography and bone scintigraphy in the prognostic evaluation of Legg-Calve-Perthes disease. Acta Radiol 1996; 37: 561-566
    CrossrefPubMedGoogle Scholar
  • 18 Keogan M, Antoun N, Wraight E. Evaluation of the skull base by SPECT. A comparison with planar scintigraphy and computed tomography. Clin Nucl Med 1994; 19: 1055-1059
    CrossrefPubMedGoogle Scholar
  • 19 Körholz D, Wirtz I, Vosberg H et al. The role of bone scintigraphy in the follow-up of osteogenic sarcoma. Eur J Cancer Part A 1996; 32: 461-464
    CrossrefPubMedGoogle Scholar
  • 20 Lassmann M, Treves ST. Pediatric Radiopharmaceutical Administration: Harmonization of the 2007 EANM Paediatric Dosage Card (Version 1.5.2008) and the 2010 North American Consensus guideline. Eur J Nucl Med Mol Imaging 2014; 41: 1636
    CrossrefPubMedGoogle Scholar
  • 21 Lim R, Fahey FH, Drubach LA et al. Early experience with fluorine-18sodium fluoride bone PET in young patients with back pain. J Pediatr Orthop 2007; 27: 277-282
    CrossrefPubMedGoogle Scholar
  • 22 Mandell G, Harcke H. Scintigraphy of spinal disorders in adolescents. Skeletal Radiol 1993; 22: 393-401
    CrossrefPubMedGoogle Scholar
  • 23 Meyer JS, Nadel HR, Marina N et al. Imaging guidelines for children with Ewing sarcoma and osteosarcoma: a report from the Children’s Oncology Group Bone Tumor Committee. Pediatr Blood Cancer 2008; 51: 163-170
    CrossrefPubMedGoogle Scholar
  • 24 Nadel HR. Pediatric Bone Scintigraphy Update. Semin Nucl Med 2010; 40: 31-40
    CrossrefPubMedGoogle Scholar
  • 25 Oshima M, Yoshihasi Y, Ito K et al. Initial stage of Legg-Calve-Perthes disease: Comparison of three-phase bone scintigraphy and SPECT with MR imaging. Eur J Radiol 1992; 15: 107-112
    CrossrefPubMedGoogle Scholar
  • 26 Reuland P, Aicher KP, Dopfer R et al. Differential diagnosis of the infantile osteomyelitis – classification according to scintigraphic, radiologic and magnet resonance tomographic findings. Nuklearmedizin 1996; 35: 68-77
    PubMedGoogle Scholar
  • 27 Roach PJ, Connolly LP, Zurakowski D et al. Osteoid Osteoma: Comparative utility of high-resolution planar and pinhole magnification scintigraphy. Paediatr Radiol 1996; 26: 222-225
    CrossrefPubMedGoogle Scholar
  • 28 Roßmüller B, Hahn K, Fischer S. Bone scintigraphy in non-neoplastic diseases in children. Quart J Nucl Med 1998; 42: 133-147
    PubMedGoogle Scholar
  • 29 Sathekge M, Clauss R. Criteria and quantification of fibrous dysplasia on MDP scanning. Nuklearmedizin 1995; 34: 229-231
    PubMedGoogle Scholar
  • 30 Stauss J, Hahn K, Mann M et al. Guidelines for paediatric bone scanning with 99mTc-labelled radiopharmaceuticals an 18F-fluoride. Eur J Nucl Med Mol Imaging 2010; 37: 1621-1628
    CrossrefPubMedGoogle Scholar
  • 31 Wilcox J, Moniot A, Green J. Bone scanning in the evaluation of exercise related stress injuries. Radiology 1977; 123: 669-673
    PubMedGoogle Scholar