Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000032.xml
Klinische Neurophysiologie 2014; 45(04): 230-232
DOI: 10.1055/s-0034-1387348
DOI: 10.1055/s-0034-1387348
Der besondere Fall
Zwerchfellstimulation bei Amyotropher Lateralsklerose mit respiratorischem Onset
Diaphragm Pacing in Amyotrophic Lateral Sclerosis with Respiratory OnsetFurther Information
Publication History
Publication Date:
07 October 2014 (online)
![](https://www.thieme-connect.de/media/klinneuro/201404/lookinside/thumbnails/10.1055-s-0034-1387348-1.jpg)
Dem Fallbericht liegt eine ungewöhnliche Erstmanifestation der Amyotrophen Lateralsklerose (ALS) mit Atembeschwerden zugrunde, wobei die Notwendigkeit einer nichtinvasiven Heimbeatmung (NIV) bereits vor Diagnosestellung bestand. Aufgrund der besonderen Befundkonstellation wurde bei erhaltener Leitfähigkeit des N. phrenicus ein Zwerchfellschrittmacher implantiert. Diese Therapieoption wurde in Deutschland bei ALS bisher nur in Einzelfällen angewendet.
-
Literatur
- 1 Kollewe K, Mauss U, Krampfl K et al. ALSFRS-R score and its ratio: a useful predictor for ALS-progression. J Neurol Sci 2008; 275: 69-73
- 2 Shoesmith CL, Findlater K, Rowe A et al. Prognosis of amyotrophic lateral sclerosis with respiratory onset. J Neurol Neurosurg Psychiatry 2007; 78: 629-631
- 3 Bourke SC, Tomlinson M, Williams TL et al. Effects of non-invasive ventilation on survival and quality of life in patients with amyotrophic lateral sclerosis: a randomised controlled trial. Lancet Neurol 2006; 5: 140-147
- 4 Synapsebiomedical. Synapse Biomedical Receives FDA Approval for NeuRx Diaphragm Pacing System (DPS)® to Treat Amyotrophic Lateral Sclerosis (ALS). (28.09.2011). Im Internet: http://www.synapsebiomedical.com/news/media/pdf/FDAApproval-ALS.pdf (Stand 05.07.2014)
- 5 Abdulla S, Vielhaber S, Körner S et al. Validation of the German version of the extended ALS functional rating scale as a patient-reported outcome measure. J Neurol 2013; 260: 2242-2255
- 6 Just N, Bautin N, Danel-Brunaud V et al. The Borg dyspnoea score: a relevant clinical marker of inspiratory muscle weakness in amyotrophic lateral sclerosis. Eur Respir J 2010; 35: 353-360
- 7 Onders RP, Elmo M, Kaplan C et al. Final analysis of the pilot trial of diaphragm pacing in amyotrophic lateral sclerosis with long-term follow-up: diaphragm pacing positively affects diaphragm respiration. Am J Surg 2014; 207: 393-397
- 8 Onders RP, Elmo M, Khansarinia S et al. Complete worldwide operative experience in laparoscopic diaphragm pacing: results and differences in spinal cord injured patients and amyotrophic lateral sclerosis patients. Surg Endosc 2009; 23: 1433-1440
- 9 Onders RP, Carlin AM, Elmo M et al. Amyotrophic lateral sclerosis: the Midwestern surgical experience with the diaphragm pacing stimulation system shows that general anesthesia can be safely performed. Am J Surg 2009; 197: 386-390
- 10 Scherer K, Bedlack RS. Diaphragm pacing in amyotrophic lateral sclerosis: a literature review. Muscle Nerve 2012; 46: 1-8